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当基因测序遭遇质疑,“功能性”精准医学赋予癌细胞更大的使命

2018-02-23 智康 MedSci原创

浅谈“功能性”精准医学在当下肿瘤临床治疗的必要性

精准医学(Precision medicine)是近来热度非常高的一个词汇。得益于基因测序技术的进步,它萌发于学术科研中心,应用在生物医药产业,更是广泛出现在各大新闻媒体当中为百姓所熟知,甚至一度成为了最热门的政治口号。然而,由于癌细胞基因的不稳定性,仅仅采用基因测序这种间接方式,在大多数情况下并不足以给出最合理的用药方案。而精准医疗不仅仅是基因测序,还包括了多层面医疗技术的使用。对个体的肿瘤细胞进行干预或扰动,从而得到重要的功能性信息,这是功能性精准医学的特点。比如基于CR(条件性重编程conditional reprogramming)原理的新一代肿瘤原代细胞培养技术对候选药物或药物组合进行精确的药理分析和药效检测,进而指导临床用药,也将成为一种更为直接、更为准确的肿瘤诊治模式。到底什么是精准医学?也许最直接的回答可以是“找到与每一位患者匹配度最高的用药方式的过程”。具体到癌症精准医学领域,也许可以理解为“根据每一位患者的不同情况,找到最大程度减小肿瘤体积或者清除患者肿瘤的治疗方法”。2015年美国联邦政府首次提出2016精准医学倡议以及2020癌症登月计划。同年,世界上相继有很多

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    2018-07-10 saikp
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    2018-02-25 yxch36
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