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Alcohol:青春期饮用混合酒精和咖啡因的功能饮料可与可卡因一样影响大脑

2016-10-28 MedSci MedSci原创

近日,来自普渡大学的一项研究表明,饮用咖啡因含量很高的酒精饮料可引起与青少年使用可卡因相似的的大脑变化,且其后果持续到成年期,该研究结果已发表于Alcohol。 研究人员对青少年喂以咖啡因含量很高的能量饮料,以观察对小鼠大脑的影响。结果发现,与对照组小鼠相比,高咖啡因能量饮料组小鼠成年期并不会饮用更多地酒精。 但是当将高水平的咖啡因与酒精混合后喂以青少年小鼠后发现小鼠大脑的物理和神经化

近日,来自普渡大学的一项研究表明,饮用咖啡因含量很高的酒精饮料可引起与青少年使用可卡因相似的的大脑变化,且其后果持续到成年期,该研究结果已发表于Alcohol。

研究人员对青少年喂以咖啡因含量很高的能量饮料,以观察对小鼠大脑的影响。结果发现,与对照组小鼠相比,高咖啡因能量饮料组小鼠成年期并不会饮用更多地酒精。

但是当将高水平的咖啡因与酒精混合后喂以青少年小鼠后发现小鼠大脑的物理和神经化学标志类似与小鼠使用可卡因后的大脑变化。

反复暴露于含咖啡因的酒精中,这些青春期的小鼠会变得越来越活跃,与给予可卡因一样。此外,研究人员还发现ΔFosB蛋白的水平升高,ΔFosB蛋白是神经化学长期改变的标志物,那些滥用药物如可卡因或吗啡的机体中水平会升高。

暴露于含咖啡因的酒精中的青春期小鼠对可卡因的影响不敏感,可能意味着这样的小鼠需要使用更多的可卡因才可获得与对照组相同的感觉。

为了检验这一理论,研究人员探究了暴露于含咖啡因的酒精中的青春期小鼠是否会消耗大量的同样愉快的物质--糖精。

结果发现,与暴露于水的小鼠相比,暴露于咖啡因/酒精的青春期小鼠糖精的饮用量明显增多,证实咖啡因/酒精暴露小鼠的大脑确实发生了化学变化。

原始出处:

Mixing energy drinks, alcohol may affect adolescent brains like cocaine. Science Daily, October 24, 2016.

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    2016-10-29 drmike

    嗯。还是要少喝

    0

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    2016-10-29 明崖

    学习了,那是否可以作为戒毒的辅助治疗

    0

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