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J Am Dent Assoc:局部涂氟是否可有效治疗早期龋?

2015-11-21 MedSci MedSci原创

J Am Dent Assoc:局部涂氟是否可有效治疗早期龋?近日,据发表于J Am Dent Assoc.的一项新的研究表明,局部氟化物的应用或可有效治疗该系统性回顾和荟萃分析评估了局部氟化物(含氟凝胶或含氟涂料)对乳牙或恒牙早期釉质龋的治疗效果。研究人员共检索了四个数据库:PubMed (MEDLINE)、CENTRAL、TRIP以及ClinicalTrials.gov。最终筛选出21篇文献做

近日,据发表于J Am Dent Assoc.的一项新的研究表明,局部氟化物的应用或可有效治疗。

该系统性回顾和荟萃分析评估了局部氟化物(含氟凝胶或含氟涂料)对乳牙或恒牙早期釉质龋的治疗效果。

研究人员共检索了四个数据库:PubMed (MEDLINE)、CENTRAL、TRIP以及ClinicalTrials.gov。最终筛选出21篇文献做全文分析,5篇进行回顾分析,3篇进行荟萃分析。对数据进行的统计分析仅用来评估含氟涂料的有效性,足够多的研究数据可用来评估含氟凝胶的有效性。两名评审员独立选择了研究,提取了数据,并对偏倚的风险进行了评估。整合效果的预估值表示为组间的平均加权差异。

结果发现,关于氟化物应用的适应症方面,治疗方法的范围相似。含氟涂料对早期釉质龋的逆转效果显著(P<0.05)。荟萃分析显示具有高异质性。

总而言之,含氟涂料似乎可有效的逆转乳牙和恒牙早期龋;但是,仍需要进一步的临床试验以探究局部氟化物治疗这些病变的有效性,主要是关于含氟凝胶的治疗效果。

考虑到已有研究证据表明局部涂氟的有效性,儿童口腔科医生可以使用含氟涂料作为治疗乳牙和恒牙表面白垩色病损的辅助治疗措施。

原始出处:

Lenzi TL, Montagner AF, Soares FZ, de Oliveira Rocha R.Are topical fluorides effective for treating incipient carious lesions?: A systematic review and meta-analysis. J Am Dent Assoc. 2015 Nov 5. pii: S0002-8177(15)00701-1. doi: 10.1016/j.adaj.2015.06.018.


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  1. [GetPortalCommentsPageByObjectIdResponse(id=124960, encodeId=ecbc12496029, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46120, encodeId=182546120d8, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de721636603, createdName=byzl, createdTime=Mon Dec 14 20:40:00 CST 2015, time=2015-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44627, encodeId=1e224462e76, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58701660184, createdName=docterdw123, createdTime=Thu Dec 03 21:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405684, encodeId=0d6814056847b, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619418, encodeId=c7f316194185b, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=)]
    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

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  2. [GetPortalCommentsPageByObjectIdResponse(id=124960, encodeId=ecbc12496029, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46120, encodeId=182546120d8, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de721636603, createdName=byzl, createdTime=Mon Dec 14 20:40:00 CST 2015, time=2015-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44627, encodeId=1e224462e76, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58701660184, createdName=docterdw123, createdTime=Thu Dec 03 21:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405684, encodeId=0d6814056847b, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619418, encodeId=c7f316194185b, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=)]
    2015-12-14 byzl

    ?

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  3. [GetPortalCommentsPageByObjectIdResponse(id=124960, encodeId=ecbc12496029, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46120, encodeId=182546120d8, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de721636603, createdName=byzl, createdTime=Mon Dec 14 20:40:00 CST 2015, time=2015-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44627, encodeId=1e224462e76, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58701660184, createdName=docterdw123, createdTime=Thu Dec 03 21:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405684, encodeId=0d6814056847b, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619418, encodeId=c7f316194185b, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=)]
    2015-12-03 docterdw123

    ?

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  4. [GetPortalCommentsPageByObjectIdResponse(id=124960, encodeId=ecbc12496029, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46120, encodeId=182546120d8, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de721636603, createdName=byzl, createdTime=Mon Dec 14 20:40:00 CST 2015, time=2015-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44627, encodeId=1e224462e76, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58701660184, createdName=docterdw123, createdTime=Thu Dec 03 21:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405684, encodeId=0d6814056847b, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619418, encodeId=c7f316194185b, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=)]
    2015-11-22 chg122
  5. [GetPortalCommentsPageByObjectIdResponse(id=124960, encodeId=ecbc12496029, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46120, encodeId=182546120d8, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de721636603, createdName=byzl, createdTime=Mon Dec 14 20:40:00 CST 2015, time=2015-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44627, encodeId=1e224462e76, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58701660184, createdName=docterdw123, createdTime=Thu Dec 03 21:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405684, encodeId=0d6814056847b, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619418, encodeId=c7f316194185b, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Nov 22 15:41:00 CST 2015, time=2015-11-22, status=1, ipAttribution=)]
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