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Diabetes Care:青年到中年肥胖进展与糖尿病!

2018-03-06 xing.T MedSci原创

由此可见,这项研究的发现强调了个人生命周期中在人群水平预防和治疗肥胖的重要性。

了解体重变化对糖尿病病程的影响是预防糖尿病的关键。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员使用来自全国健康和营养调查(NHANES)的数据,分析了从年轻到中年自我报告的体重变化与糖尿病发病之间的相关性。

研究人员将人分为四组:那些保持体重未变化的非肥胖(稳定的非肥胖者)、那些从肥胖的BMI到非肥胖BMI(体重减轻者)、那些从非肥胖BMI到肥胖的BMI(体重增加者)和那些持续肥胖(稳定肥胖者)。糖尿病状态由先前诊断的自我报告来确定,诊断年龄被用来确定糖尿病发病时间。研究人员采用调整协变量的Cox模型计算了10年随访期间体重变化相关的糖尿病发病的风险比(HRs)。

肥胖和体重减轻者与稳定肥胖者相比,患糖尿病的风险显著降低(HR为0.33,95% CI为0.14-0.76)。研究人员也观察到那些稳定的非肥胖者(HR为0.22;95% CI为0.18-0.28)和那些体重增加者(HR为0.70;95% CI为0.57-0.87)糖尿病风险较低。此外,体重减轻的肥胖者相比于稳定的非肥胖糖尿病发病率上升;然而,在体重减轻者较为罕见,并且统计学上的相关性并不显著。如果肥胖者在10年的时间内变得非肥胖,研究人员估计9.1%(95% CI为5.3-12.8)观察到的糖尿病病例是可以避免的,在这期间如果BMI保持正常,64.2%(95%CI为59.4-68.3)的糖尿病病例可以避免。

由此可见,这项研究的发现强调了个人生命周期中在人群水平预防和治疗肥胖的重要性。

原始出处:


Andrew Stokes,et al. Obesity Progression Between Young Adulthood and Midlife and Incident Diabetes: A Retrospective Cohort Study of U.S. Adults.Diabetes Care.2018. https://doi.org/10.2337/dc17-2336

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    2018-03-07 oo3sbrave_32914303

    谢谢分享!

    0

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    2018-03-07 yfjms

    学习

    0

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    2018-03-06 王秀

    学习了.涨知识了!

    0

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    2018-03-06 龙胆草

    学习谢谢分享

    0

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    2018-03-06 大爰

    学习了谢谢分享!!

    0

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