Baidu
map

Rsc Advances:监测抗癌药物毒副作用的“体内芯片”装置

2017-08-28 佚名 medicalxpress

京都大学日本综合细胞材料科学研究所(iCeMS)的研究人员设计了一种能够测试药物对人体细胞的副作用的小型“体内芯片”装置。该装置解决了当前类似的微流体装置的一些问题,并为下一代临床前药物测试提供了希望。



京都大学日本综合细胞材料科学研究所(iCeMS)的研究人员设计了一种能够测试药物对人体细胞的副作用的小型“体内芯片”装置。该装置解决了当前类似的微流体装置的一些问题,并为下一代临床前药物测试提供了希望。

综合心脏/芯片癌(iHCC)用于测试抗癌药物多柔比星对心脏细胞的毒性。由iCeMS的Ken-iichiroKamei领导的研究人员发现,虽然药物本身对心脏细胞无毒性,但与癌细胞相互作用产生的药物代谢物却有毒性。

该装置小于显微镜载玻片。它包含六个小区间;每两个通过微通道连接一系列入口和阀门。气动泵控制流体通过通道的运动。每两个房间及其独立的微通道系统构成一个测试台。设备中的三个测试床允许在每张床上引入微小的变化以同时比较结果。

该小组首先测试了多柔比星对小孔分离培养的心脏细胞和肝癌细胞的影响。该药物对癌细胞具有预期的抗癌作用,而不会对心脏细胞造成损害。

然后他们使用iHCC设备运行测试。将心脏细胞放置在一个室中,同时将肝癌细胞置于另一个室中。将阿霉素引入循环通过连接两个腔室的微通道的闭环系统的细胞培养基,模拟血液的循环系统。以这种方式,药物以连续的环路单向流过两个腔室。

该小组发现癌症和心脏细胞都有毒性迹象。他们假设,作为多柔比星与癌细胞相互作用的代谢副产物的化合物引起毒性作用。

为了测试这一点,他们将多柔比星添加到分别培养心脏细胞和肝癌细胞的小孔中。它对心脏细胞有毒性,但对癌细胞无毒性。

当单独的多柔比星加入到肝癌细胞中时,产生的副产物的量太小而不能对心脏细胞有毒性。该团队认为这是因为基于测试所需的细胞培养基的量会稀释代谢物。

相比之下,当将多柔比星引入iHCC时,当通过微通道循环系统移动时,代谢物不被稀释,因为需要较小体积的细胞培养物。因此,该药物通过其代谢物确实对心脏细胞具有毒性作用。

该设备需要进一步改进,但研究表明,如何在昂贵的临床试验之前将此设计概念用于研究抗癌药物对心脏细胞的毒副作用。该研究发表在皇家化学进步学会杂志上。

原始出处:

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1824252, encodeId=69291824252ad, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Mar 31 13:09:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078790, encodeId=8a6a20e8790fe, content=<a href='/topic/show?id=6dbc635680d' target=_blank style='color:#2F92EE;'>#毒副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63568, encryptionId=6dbc635680d, topicName=毒副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 04 09:09:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308235, encodeId=660a13082350f, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314707, encodeId=e9a21314e07d3, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458947, encodeId=1f7a145894e6b, content=<a href='/topic/show?id=53cc8691532' target=_blank style='color:#2F92EE;'>#芯片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86915, encryptionId=53cc8691532, topicName=芯片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8bf76117088, createdName=lixiaol, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238329, encodeId=e250238329d2, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 29 12:30:08 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1824252, encodeId=69291824252ad, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Mar 31 13:09:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078790, encodeId=8a6a20e8790fe, content=<a href='/topic/show?id=6dbc635680d' target=_blank style='color:#2F92EE;'>#毒副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63568, encryptionId=6dbc635680d, topicName=毒副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 04 09:09:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308235, encodeId=660a13082350f, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314707, encodeId=e9a21314e07d3, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458947, encodeId=1f7a145894e6b, content=<a href='/topic/show?id=53cc8691532' target=_blank style='color:#2F92EE;'>#芯片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86915, encryptionId=53cc8691532, topicName=芯片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8bf76117088, createdName=lixiaol, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238329, encodeId=e250238329d2, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 29 12:30:08 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1824252, encodeId=69291824252ad, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Mar 31 13:09:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078790, encodeId=8a6a20e8790fe, content=<a href='/topic/show?id=6dbc635680d' target=_blank style='color:#2F92EE;'>#毒副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63568, encryptionId=6dbc635680d, topicName=毒副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 04 09:09:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308235, encodeId=660a13082350f, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314707, encodeId=e9a21314e07d3, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458947, encodeId=1f7a145894e6b, content=<a href='/topic/show?id=53cc8691532' target=_blank style='color:#2F92EE;'>#芯片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86915, encryptionId=53cc8691532, topicName=芯片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8bf76117088, createdName=lixiaol, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238329, encodeId=e250238329d2, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 29 12:30:08 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1824252, encodeId=69291824252ad, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Mar 31 13:09:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078790, encodeId=8a6a20e8790fe, content=<a href='/topic/show?id=6dbc635680d' target=_blank style='color:#2F92EE;'>#毒副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63568, encryptionId=6dbc635680d, topicName=毒副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 04 09:09:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308235, encodeId=660a13082350f, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314707, encodeId=e9a21314e07d3, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458947, encodeId=1f7a145894e6b, content=<a href='/topic/show?id=53cc8691532' target=_blank style='color:#2F92EE;'>#芯片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86915, encryptionId=53cc8691532, topicName=芯片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8bf76117088, createdName=lixiaol, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238329, encodeId=e250238329d2, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 29 12:30:08 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
    2017-08-30 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1824252, encodeId=69291824252ad, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Mar 31 13:09:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078790, encodeId=8a6a20e8790fe, content=<a href='/topic/show?id=6dbc635680d' target=_blank style='color:#2F92EE;'>#毒副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63568, encryptionId=6dbc635680d, topicName=毒副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 04 09:09:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308235, encodeId=660a13082350f, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314707, encodeId=e9a21314e07d3, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458947, encodeId=1f7a145894e6b, content=<a href='/topic/show?id=53cc8691532' target=_blank style='color:#2F92EE;'>#芯片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86915, encryptionId=53cc8691532, topicName=芯片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8bf76117088, createdName=lixiaol, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238329, encodeId=e250238329d2, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 29 12:30:08 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
    2017-08-30 lixiaol
  6. [GetPortalCommentsPageByObjectIdResponse(id=1824252, encodeId=69291824252ad, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Mar 31 13:09:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078790, encodeId=8a6a20e8790fe, content=<a href='/topic/show?id=6dbc635680d' target=_blank style='color:#2F92EE;'>#毒副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63568, encryptionId=6dbc635680d, topicName=毒副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 04 09:09:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308235, encodeId=660a13082350f, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314707, encodeId=e9a21314e07d3, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458947, encodeId=1f7a145894e6b, content=<a href='/topic/show?id=53cc8691532' target=_blank style='color:#2F92EE;'>#芯片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86915, encryptionId=53cc8691532, topicName=芯片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8bf76117088, createdName=lixiaol, createdTime=Wed Aug 30 09:09:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238329, encodeId=e250238329d2, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 29 12:30:08 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
    2017-08-29 ylzr123

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

相关资讯

JCO:抗癌药物评价工具的临床获益如何?

近几年,美国临床肿瘤学会(American Society of Clinical Oncology ,ASCO)发布了抗癌药评价体系“价值框架”(value framework),又称为ASCO价值框架;欧洲肿瘤内科学会(European Society of Medical Oncology,ESMO)推出了一款用于协助肿瘤临床医师为其患者评估最为有效抗癌药物的工具——ESMO-MCBS,但二

Cell子刊:为何抗癌药物无法渗透实体瘤?肿瘤内部压力大是重要原因

许多癌症治疗药物疗效不佳,其中一个原因就在于这些药物无法渗入实体瘤内部的高压环境。根据发表在国际学术期刊Biophysical Journal上的最新研究结果,透明质酸可导致肿瘤内部形成胶状液态压力环境,是导致癌症药物无法渗入的重要原因。   来自美国西雅图弗雷德哈金森癌症研究中心的Sunil Hingorani表示:"我们发现肿瘤内部的胶状液态环境是胰腺癌产生药物抵抗的主要机制

JCI:抗癌药物剂量可决定癌细胞命运

最近,来自意大利的研究人员在国际学术期刊JCI上发表了一项最新研究进展,他们在这项研究中深入分析了癌症病人对不同剂量酪氨酸激酶抑制剂舒尼替尼产生应答和抵抗的双重机制,这为该药物的应用以及解决病人对该药物的耐受问题提供了重要信息。苹果酸舒尼替尼是一种口服的小分子多靶点受体酪氨酸激酶抑制剂。作为一种ATP竞争拮抗剂,舒尼替尼能够抑制包括VEGFR,PDGFR和干细胞/">干细胞因子受体(

Cell:微管结构助力抗癌药物开发

微管是直径仅有几纳米的微管蛋白的空心纤维,其可以形成活细胞的骨架并且在细胞分裂的过程中扮演着重要的角色;近日,刊登在Cell上的一篇报告中,来自加利福尼亚大学等处的研究者通过联合研究,将冷冻电镜技术同特殊的成像分析方法进行结合,成功地从原子视野对微管进行了观察,这对于理解微管在末端结合蛋白中的功能提供了一定帮助,而末端结合蛋白则可以调节微管的动态不稳定性。在有丝分裂期间微管可以拆解重新形成纺锤体

Cell:肠道菌会改变抗癌药物的活性

美国UCL大学领导的研究分析了线虫中药物和营养的微生物过程,该研究显示癌症药物的活性变化取决于生活在肠道内的细菌种类。这一发现凸显了操纵肠道菌和饮食来改善癌症治疗的潜在益处,以及了解个体间药物效用差异的价值。这篇研究文章发表在4月21的 cell上,通过一个新的高通量筛选方法,阐明了宿主之间复杂的关系,以及肠道微生物与药物的作用。研究人员回应媒体采访研究的领导者Filipe Cabreiro博士说

Nat Nanotech:中国药科大张灿教授巧用免疫细胞运输药物,穿透血脑屏障对抗恶性脑瘤

6月19日,中国药科大学的张灿教授团队在《Nature Nanotechnology》期刊发表了最新研究成果,揭示了一种对抗恶性脑瘤的新策略:利用免疫细胞运输抗癌药物,穿透血脑屏障对抗残留肿瘤细胞。这一策略能够抑制肿瘤复发,延长患癌小鼠的寿命。

Baidu
map
Baidu
map
Baidu
map