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Stroke:动脉弯曲度是儿童卒中的影像学生物标志物

2016-03-30 MedSci MedSci原创

动脉病变是儿童动脉性缺血性卒中的首要病因。其机制知之甚少,可能包括遗传性动脉结构异常。成人的颅外夹层卒中与结缔组织病相关。局灶大脑动脉病变是一种常见的症候,其机制尚不清楚,但可能包括颅内动脉夹层或者短暂的动脉病变。我们旨在量化儿童动脉性缺血性卒中患者的大脑动脉弯曲度,并推测在夹层时弯曲度增加。 研究方法:1个月到18岁的动脉性缺血性卒中的儿童被纳入小儿卒中血管感染因素(VIPS)研究,对

动脉病变是儿童动脉性缺血性卒中的首要病因。其机制知之甚少,可能包括遗传性动脉结构异常。成人的颅外夹层卒中与结缔组织病相关。局灶大脑动脉病变是一种常见的症候,其机制尚不清楚,但可能包括颅内动脉夹层或者短暂的动脉病变。我们旨在量化儿童动脉性缺血性卒中患者的大脑动脉弯曲度,并推测在夹层时弯曲度增加。

研究方法:1个月到18岁的动脉性缺血性卒中的儿童被纳入小儿卒中血管感染因素(VIPS)研究,对照组来自卡尔加里小儿卒中项目。客观的多个研究者回顾了已定义的诊断分类。使用经过验证的图像软件在三维时间飞跃磁共振血管造影原始图像上对主要大脑的平均动脉弯曲度进行计算。未受影响的血管弯曲度与儿童夹层卒中、短暂大脑动脉病变卒中、脑膜炎卒中、烟雾病卒中、心源性卒中的血管进行比较。使用T检验比较外伤相关及自发性动脉夹层。

研究结果:研究纳入115个儿童(中位年龄6.8岁,43%女性)。组间年龄和性别相似。弯曲度的平均值和变化率和效度检验保持一致。对照组弯曲度(1.346±0.074;n=15)和烟雾病(1.324±0.038; n=15; P=0.998)、脑膜炎(1.348±0.052; n=11; P=0.989)、心源性(1.379±0.056; n=27; P=0.190)相当。弯曲度在颅外夹层(1.404±0.084;n=22; P=0.021)和短暂性脑动脉病变(1.390±0.040; n=27; P=0.001)的儿童中更高。在外伤性和自发性的夹层中弯曲度没有差别(P=0.70)。

研究结论:在夹层、短暂脑动脉病变的儿童中,其动脉弯曲度增加。量化动脉弯曲度可能为小儿卒中提供一个临床相关的影像生物标志物。

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    2016-03-31 milkshark

    好文章啊

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1700552, encodeId=782f1e0055211, content=<a href='/topic/show?id=31922821154' target=_blank style='color:#2F92EE;'>#儿童卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28211, encryptionId=31922821154, topicName=儿童卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee4730165441, createdName=piaojinhua, createdTime=Tue May 31 21:24:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840881, encodeId=e76b184088155, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Apr 22 15:24:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560551, encodeId=d5c315605514a, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Apr 01 01:24:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566560, encodeId=0083156656068, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Apr 01 01:24:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74982, encodeId=e65ae498255, content=好文章啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Thu Mar 31 07:43:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74983, encodeId=99e6e4983cc, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=168, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Thu Mar 31 07:43:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74906, encodeId=f54ce490644, content=这又是一个新的指标,其实形态学的背后,可能是病理过程, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Wed Mar 30 16:35:00 CST 2016, time=2016-03-30, status=1, ipAttribution=)]
    2016-03-31 milkshark

    好好学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1700552, encodeId=782f1e0055211, content=<a href='/topic/show?id=31922821154' target=_blank style='color:#2F92EE;'>#儿童卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28211, encryptionId=31922821154, topicName=儿童卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee4730165441, createdName=piaojinhua, createdTime=Tue May 31 21:24:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840881, encodeId=e76b184088155, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Apr 22 15:24:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560551, encodeId=d5c315605514a, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Apr 01 01:24:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566560, encodeId=0083156656068, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Apr 01 01:24:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74982, encodeId=e65ae498255, content=好文章啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Thu Mar 31 07:43:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74983, encodeId=99e6e4983cc, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=168, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Thu Mar 31 07:43:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74906, encodeId=f54ce490644, content=这又是一个新的指标,其实形态学的背后,可能是病理过程, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Wed Mar 30 16:35:00 CST 2016, time=2016-03-30, status=1, ipAttribution=)]
    2016-03-30 lovetcm

    这又是一个新的指标,其实形态学的背后,可能是病理过程

    0

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