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IGF-1表达与脑膜瘤细胞增殖活性有关

2012-04-27 鲍爱宁摘编 医学论坛网

  最近,石家庄市第三医院神经外科、河北医科大学第二医院的研究人员的一项研究显示, IGF-1表达强度与脑膜瘤细胞增殖活性有关,与增殖细胞核抗原(PCNA)在脑膜瘤的发生、增殖和恶化过程中可能起协同作用,其详细机制有待进一步研究。该研究发表于2012年第1期《脑与神经疾病杂志》。   该研究旨在探讨IGF-1在人脑膜瘤中的表达与脑膜瘤细胞增殖活性之间的关系。   武海龙等研究人员应用

  最近,石家庄市第三医院神经外科、河北医科大学第二医院的研究人员的一项研究显示, IGF-1表达强度与脑膜瘤细胞增殖活性有关,与增殖细胞核抗原(PCNA)在脑膜瘤的发生、增殖和恶化过程中可能起协同作用,其详细机制有待进一步研究。该研究发表于2012年第1期《脑与神经疾病杂志》。

  该研究旨在探讨IGF-1在人脑膜瘤中的表达与脑膜瘤细胞增殖活性之间的关系。

  武海龙等研究人员应用免疫组化SP法检测42例脑膜瘤组织、7例正常硬脑膜中IGF-1和PCNA的表达情况,结果进行统计学分析。

  结果显示,IGF-1在正常硬脑膜组、WHO I、II和III级脑膜瘤组的表达强度不等,分别为0%、(15.7±12.8)%、(47.2±11.7)%和(62.9±12.9)%,其差异均具有统计学意义(P<0.05)。PCNA在同样四个组别中的PCNA-LI值分别为0%、9.6±5.4%、30.6±5.6%和48.7±15.1%,其差异亦均具有统计学意义(P<0.05)。相关分析结果显示:IGF-1与PCNA-LI两者呈正相关。     

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    2012-11-07 qingrejiedu
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    2012-06-22 xxxx1049
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