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PLoS Biology:轻微“饥饿感”有助于增强学习力

2017-08-04 佚名 生物探索

众所周知,在动物和人体模型中,摄入较少的热量会给健康带来许多好处,包括延年益寿和提高学习能力。然而,关于这些结果之间的联系还不清楚。

众所周知,在动物和人体模型中,摄入较少的热量会给健康带来许多好处,包括延年益寿和提高学习能力。然而,关于这些结果之间的联系还不清楚。

8月1日发表在PLoS生物学上的一项研究揭示:吃得少能让蠕虫(Caenorhabditis elegans)的思维变敏捷,限制卡路里摄入可能还会促进大脑发展,是强化学习的分子基础。

据悉,这项研究由美国加州大学旧金山分校的Kaveh Ashrafi和同事发现。他们通过一项试验,要求蠕虫学会辨别食物和辛辣化学物质的气味之间的联系,具有辨别能力的蠕虫需要在酒精上寻找化学物质特有的气味。

研究发现,空腹1小时或0.5小时可以降低色氨酸的分解产物——犬尿喹啉酸(kynurenic acid)。高水平的犬尿喹啉酸可以调节蠕虫联想学习任务神经元内的阻止谷氨酸信号。通过限制食物摄入可以降低犬尿喹啉酸,从而提高蠕虫的学习能力。

限制饮食与促进学习的模型

Kaveh Ashrafi在新闻发布会上表示:犬尿喹啉酸影响哺乳动物学习力的证据还有待确定,不过类似的现象同样地出现在哺乳动物中。一项2008年的研究发现,卡路里摄入减少30%的60岁左右的人,更擅长学习单词列表。

来自澳大利亚悉尼大学的Devin Wahl表示,从进化论的角度来看,这是合理的。当你在寻找食物时,大脑运行需要维持在高水平状态,因为你正试图击败竞争者。一旦你吃过一顿大餐后,就只想要睡觉了。

不过,也有研究发现,强烈的饥饿感会损伤认知功能,这可能是因为过度饥饿让人们全神贯注于对食物的念想上。

原始出处:
Vohra M, Lemieux GA, Lin L, Ashrafi K.The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite.PLoS Biol. 2017 Aug 1;15(8):e2002032. doi: 10.1371/journal.pbio.2002032. eCollection 2017 Aug.

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    2018-06-07 sunylz
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    2017-08-06 Medsci0421

    谢谢分享。学习了

    0

  4. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229919, encodeId=93b72299193f, content=适量饮食,有利健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Aug 04 10:34:04 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
  5. 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content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Aug 05 00:29:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229930, encodeId=1ba2229930e4, content=学习了,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Aug 04 10:38:33 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229919, encodeId=93b72299193f, content=适量饮食,有利健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Aug 04 10:34:04 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-06 xlysu
  6. 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content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Aug 05 00:29:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229930, encodeId=1ba2229930e4, content=学习了,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Aug 04 10:38:33 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229919, encodeId=93b72299193f, content=适量饮食,有利健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Aug 04 10:34:04 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-06 xlysu
  7. 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content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Aug 05 00:29:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229930, encodeId=1ba2229930e4, content=学习了,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Aug 04 10:38:33 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229919, encodeId=93b72299193f, content=适量饮食,有利健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Aug 04 10:34:04 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-05 人间可客

    学习了,谢谢分享!

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101187, encryptionId=6c5210118e6c, topicName=饥饿感)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74e015060438, createdName=xlysu, createdTime=Sun Aug 06 01:04:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230253, encodeId=3db8230253e4, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuEJWOf8El7MfqtlSpy4eWtPl5cxmNJ4ezwbFf5vtCeh53ITyabFpFIJfKTPlzdh6ibOibVONwHUbm9/0, createdBy=a4351715107, createdName=人间可客, createdTime=Sat Aug 05 07:49:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230110, encodeId=63ee23011022, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Aug 05 00:29:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229930, encodeId=1ba2229930e4, content=学习了,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Aug 04 10:38:33 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229919, encodeId=93b72299193f, content=适量饮食,有利健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Aug 04 10:34:04 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-05 jihuaijun1112

    学习学习学习

    0

  9. 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content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Aug 05 00:29:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229930, encodeId=1ba2229930e4, content=学习了,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Aug 04 10:38:33 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229919, encodeId=93b72299193f, content=适量饮食,有利健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Aug 04 10:34:04 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-04 1ddf0692m34(暂无匿称)

    学习了,值得分享

    0

  10. 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content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Aug 05 00:29:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229930, encodeId=1ba2229930e4, content=学习了,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Aug 04 10:38:33 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229919, encodeId=93b72299193f, content=适量饮食,有利健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Aug 04 10:34:04 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-04 1e0f8808m18(暂无匿称)

    适量饮食,有利健康。

    0

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