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JAMA Pediatr:孕期体重、分娩方式、肠道微生物对儿童体重超标的影响

2018-03-05 zhangfan MedSci原创

研究认为,孕期超重母亲接受剖腹产导致后代超重风险增加,而肠道微生物在其中发挥了重要作用

母亲超重常导致剖宫产,是儿童超重的一个强危险因素,近日研究人员考察了出生方式对新生儿肠道微生物的影响,并考察这种关系对儿童期体重的影响。

研究考察了935名新生儿数据,记录孕期母亲体重指数,定义正常体重为BMI 18.5-24.9,超过25为超重,出生3.7个月后对新生儿肠道微生物进行16s核糖体RNA测序。在1和3岁进行体重测试,并调整性别及年龄因素。研究的主要终点是儿童1和3岁时超重风险。

新生儿母亲平均年龄32.5岁,其中382人超重(40.9%)。新生儿中69人1岁时超重,90人3岁时超重。相比于体重正常阴道产的新生儿,超重母亲阴道产的新生儿1岁时超重风险增加3倍(OR, 3.33; 95% CI, 1.49-7.41),超重母亲剖腹产新生儿1岁时超重风险增加5倍(OR, 5.02; 95% CI, 2.04-12.38)。3岁结果与1岁类似。模型研究显示,出生方式、新生儿肠道微生物、孕妇超重与1、3岁儿童超重相关。母亲超重新生儿毛螺旋菌科丰度增加,而阴道分娩与剖腹产新生儿毛螺菌科丰度差异显著。

研究认为,孕期超重母亲接受剖腹产导致后代超重风险增加,而肠道微生物在其中发挥了重要作用。

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createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:57:47 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
  5. 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objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 12:03:15 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293542, encodeId=ceb42935427f, content=CC吃吃吃vv滚滚滚红红火火, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:58:08 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293541, encodeId=8946293541b7, content=CC吃吃吃v, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:57:47 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-12-24 feather89
  6. 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createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:57:47 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-03-07 虈亣靌

    不错!好好学习一下

    0

  7. 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  8. 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encryptionId=9e633154e6b, topicName=分娩方式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00d929475476, createdName=stfoxst, createdTime=Sat Feb 02 12:08:00 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727122, encodeId=7a461e2712253, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 24 09:08:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293905, encodeId=dd26293905cc, content=不错!好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Mar 07 18:24:56 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275138, encodeId=7a9112e513881, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Wed Mar 07 02:08:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293546, encodeId=35512935462d, content=VB吧哈哈哈叫姐姐, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 12:03:15 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293542, encodeId=ceb42935427f, content=CC吃吃吃vv滚滚滚红红火火, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:58:08 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293541, encodeId=8946293541b7, content=CC吃吃吃v, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:57:47 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-03-06 为你把脉

    VB吧哈哈哈叫姐姐

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2052749, encodeId=e3fa2052e4988, content=<a href='/topic/show?id=867845281c6' target=_blank style='color:#2F92EE;'>#孕期体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45281, encryptionId=867845281c6, topicName=孕期体重)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Thu Jan 24 11:08:00 CST 2019, time=2019-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824889, encodeId=b3c718248896e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, 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encryptionId=9e633154e6b, topicName=分娩方式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00d929475476, createdName=stfoxst, createdTime=Sat Feb 02 12:08:00 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727122, encodeId=7a461e2712253, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 24 09:08:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293905, encodeId=dd26293905cc, content=不错!好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Mar 07 18:24:56 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275138, encodeId=7a9112e513881, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Wed Mar 07 02:08:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293546, encodeId=35512935462d, content=VB吧哈哈哈叫姐姐, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 12:03:15 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293542, encodeId=ceb42935427f, content=CC吃吃吃vv滚滚滚红红火火, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:58:08 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293541, encodeId=8946293541b7, content=CC吃吃吃v, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:57:47 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-03-06 为你把脉

    CC吃吃吃vv滚滚滚红红火火

    0

  10. 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encryptionId=9e633154e6b, topicName=分娩方式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00d929475476, createdName=stfoxst, createdTime=Sat Feb 02 12:08:00 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727122, encodeId=7a461e2712253, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 24 09:08:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293905, encodeId=dd26293905cc, content=不错!好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Mar 07 18:24:56 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275138, encodeId=7a9112e513881, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Wed Mar 07 02:08:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293546, encodeId=35512935462d, content=VB吧哈哈哈叫姐姐, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 12:03:15 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293542, encodeId=ceb42935427f, content=CC吃吃吃vv滚滚滚红红火火, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:58:08 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293541, encodeId=8946293541b7, content=CC吃吃吃v, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Mar 06 11:57:47 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-03-06 为你把脉

    CC吃吃吃v

    0

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