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Clin Exp Otorhinolaryngol:虎耳草在过敏性鼻炎中的抗过敏作用研究

2019-04-19 AlexYang MedSci原创

虎耳草提取物具有抗癌、抗过敏和抗氧化活性。最近,有研究人员调查了虎耳草提取物对过敏性鼻炎炎症中的作用。研究包括了4个不同的小组(组A:对照组;组B:过敏性鼻炎组;组C:300mg/kg处理组;组D:600mg/kg处理组),实验对象为BALB/c小鼠。研究发现,虎耳草提取物在组C和组D中对鼻症状、IL-13 mRNA的表达、鼻组织中嗜酸性细胞浸润/杯状细胞增生和OVA特异性lgE的产生均表现出了明

虎耳草提取物具有抗癌、抗过敏和抗氧化活性。最近,有研究人员调查了虎耳草提取物对过敏性鼻炎炎症中的作用。

研究包括了4个不同的小组(组A:对照组;组B:过敏性鼻炎组;组C:300mg/kg处理组;组D:600mg/kg处理组),实验对象为BALB/c小鼠。研究发现,虎耳草提取物在组C和组D中对鼻症状、IL-13 mRNA的表达、鼻组织中嗜酸性细胞浸润/杯状细胞增生和OVA特异性lgE的产生均表现出了明显的抑制作用。在组D中,与组B相比,虎耳草提取物治疗能够下调IL-4, IL-5, IL-13, TNF-α和IL-10细胞因子表达以及显著的减少血清IgG2a和IgG1的水平(P<0.05)。然而,IL-5、干扰素-γ和叉头盒P3 mRNA的表达在组C和组D中并没有发生变化。

最后,研究人员指出,虎耳草能够通过抑制2型T辅助细胞因子(IL-13)产生、OVA特异性lgE形成、杯状细胞增生和嗜酸性细胞浸润来诱导抗过敏性炎症作用。因此,虎耳草可以考虑作为治疗过敏性鼻炎的潜在治疗药物。

原始出处:

Zhang YL, Shin HJ, Lee JH et al. Antiallergic Effect of Hizikia fusiformis in an Ovalbumin-Induced Allergic Rhinitis Mouse Model. Clin Exp Otorhinolaryngol. May 2019.

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    2019-09-17 amyloid
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    2019-04-23 1ddf0692m34(暂无匿称)

    学习了,长知识

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