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JAMA:儿童自闭症与脑神经元数量过多有关

2011-11-13 MedSci原创 MedSci原创

美国研究人员11月8日公布的一项小型研究结果显示,与普通儿童相比,自闭症患儿大脑前额叶皮层的神经元数量过多。这项发现有助理解自闭症的病因。   前额叶皮层是大脑中最重要的区域之一,参与人体的语言、交流、社会行为、情绪以及注意力等高级功能。自闭症患儿的这些高级功能通常有所欠缺。   美国加利福尼亚州圣迭戈大学的研究人员对7名自闭症患儿及6名普通男孩的前额叶皮层进行了检查,

美国研究人员11月8日公布的一项小型研究结果显示,与普通儿童相比,自闭症患儿大脑前额叶皮层的神经元数量过多。这项发现有助理解自闭症的病因。
 
前额叶皮层是大脑中最重要的区域之一,参与人体的语言、交流、社会行为、情绪以及注意力等高级功能。自闭症患儿的这些高级功能通常有所欠缺。
 
美国加利福尼亚州圣迭戈大学的研究人员对7名自闭症患儿及6名普通男孩的前额叶皮层进行了检查,这些男孩的年龄在2至16岁之间。结果发现,自闭症患儿前额叶的神经元数量比普通儿童多67%,其平均脑重量也更重。
 
这项研究成果9日将发表在新一期《美国医学会杂志》上。研究人员表示,由于皮层神经元在患儿出生前而不是出生后产生,这表明自闭症的出现可能与患儿胎儿期的神经细胞生长或维持出现错误有关,另一个导致患儿神经元过多的可能因素是其细胞凋亡机制出现紊乱。(来源:新华社 任海军)
  

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2009359, encodeId=0c692009359de, content=<a href='/topic/show?id=df47284508e' target=_blank style='color:#2F92EE;'>#儿童自闭症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28450, encryptionId=df47284508e, topicName=儿童自闭症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue May 01 06:41:00 CST 2012, time=2012-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709584, encodeId=f46d1e09584e0, content=<a href='/topic/show?id=a919849e3ff' target=_blank style='color:#2F92EE;'>#脑神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84973, encryptionId=a919849e3ff, topicName=脑神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8031759349, createdName=siiner, createdTime=Thu Jan 05 06:41:00 CST 2012, time=2012-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4126, encodeId=65ce4126c2, content=很多疾病的研究更深入了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=weimei0117, createdTime=Thu Mar 22 09:29:00 CST 2012, time=2012-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527510, encodeId=1abe152e5106c, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Tue Nov 15 09:41:00 CST 2011, time=2011-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3671, encodeId=e76836e150, content=见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97f50070, createdName=zhangzhaolei, createdTime=Mon Nov 14 11:30:00 CST 2011, time=2011-11-14, status=1, ipAttribution=)]
    2012-01-05 siiner
  3. [GetPortalCommentsPageByObjectIdResponse(id=2009359, encodeId=0c692009359de, content=<a href='/topic/show?id=df47284508e' target=_blank style='color:#2F92EE;'>#儿童自闭症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28450, encryptionId=df47284508e, topicName=儿童自闭症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue May 01 06:41:00 CST 2012, time=2012-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709584, encodeId=f46d1e09584e0, content=<a href='/topic/show?id=a919849e3ff' target=_blank style='color:#2F92EE;'>#脑神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84973, encryptionId=a919849e3ff, topicName=脑神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8031759349, createdName=siiner, createdTime=Thu Jan 05 06:41:00 CST 2012, time=2012-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4126, encodeId=65ce4126c2, content=很多疾病的研究更深入了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=weimei0117, createdTime=Thu Mar 22 09:29:00 CST 2012, time=2012-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527510, encodeId=1abe152e5106c, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Tue Nov 15 09:41:00 CST 2011, time=2011-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3671, encodeId=e76836e150, content=见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97f50070, createdName=zhangzhaolei, createdTime=Mon Nov 14 11:30:00 CST 2011, time=2011-11-14, status=1, ipAttribution=)]
    2012-03-22 weimei0117

    很多疾病的研究更深入了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2009359, encodeId=0c692009359de, content=<a href='/topic/show?id=df47284508e' target=_blank style='color:#2F92EE;'>#儿童自闭症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28450, encryptionId=df47284508e, topicName=儿童自闭症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue May 01 06:41:00 CST 2012, time=2012-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709584, encodeId=f46d1e09584e0, content=<a href='/topic/show?id=a919849e3ff' target=_blank style='color:#2F92EE;'>#脑神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84973, encryptionId=a919849e3ff, topicName=脑神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8031759349, createdName=siiner, createdTime=Thu Jan 05 06:41:00 CST 2012, time=2012-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4126, encodeId=65ce4126c2, content=很多疾病的研究更深入了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=weimei0117, createdTime=Thu Mar 22 09:29:00 CST 2012, time=2012-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527510, encodeId=1abe152e5106c, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Tue Nov 15 09:41:00 CST 2011, time=2011-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3671, encodeId=e76836e150, content=见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97f50070, createdName=zhangzhaolei, createdTime=Mon Nov 14 11:30:00 CST 2011, time=2011-11-14, status=1, ipAttribution=)]
    2011-11-15 xiongke014
  5. [GetPortalCommentsPageByObjectIdResponse(id=2009359, encodeId=0c692009359de, content=<a href='/topic/show?id=df47284508e' target=_blank style='color:#2F92EE;'>#儿童自闭症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28450, encryptionId=df47284508e, topicName=儿童自闭症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue May 01 06:41:00 CST 2012, time=2012-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709584, encodeId=f46d1e09584e0, content=<a href='/topic/show?id=a919849e3ff' target=_blank style='color:#2F92EE;'>#脑神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84973, encryptionId=a919849e3ff, topicName=脑神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8031759349, createdName=siiner, createdTime=Thu Jan 05 06:41:00 CST 2012, time=2012-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4126, encodeId=65ce4126c2, content=很多疾病的研究更深入了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=weimei0117, createdTime=Thu Mar 22 09:29:00 CST 2012, time=2012-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527510, encodeId=1abe152e5106c, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Tue Nov 15 09:41:00 CST 2011, time=2011-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3671, encodeId=e76836e150, content=见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97f50070, createdName=zhangzhaolei, createdTime=Mon Nov 14 11:30:00 CST 2011, time=2011-11-14, status=1, ipAttribution=)]
    2011-11-14 zhangzhaolei

    见识了

    0

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