JCEM：血清25（OH）D水平与肺功能呈正相关

在东亚人群，维生素D水平与肺功能的关系尚不清楚。为了探讨在韩国成年人，血清25–羟维生素D（25（OH）D）与肺功能的关系，来自韩国天主教大学首尔圣玛丽医院Churl Min Kim教授及其团队进行了一项研究，该研究发现血清25（OH）D水平与肺功能呈正相关，这种关系在易患肺结核的受试者表现的更加突出。该研究结果在线发表在3月26日的美国《临床内分泌代谢杂志》（The journal of clinical endocrinology & metabolism）上。
该研究中，对来自韩国国民健康和营养调查（KNHANES）（在2008至2010年期间进行的一项韩国公民的横断面调查）的数据进行分析。在韩国16个行政区选取共计10096例19岁及以上的受试者。主要评价指标是血清25（OH）D与肺功能（第一秒用力呼气容积（FEV1）和用力肺活量（FVC））。
该研究结果表明，在控制年龄、性别、身高和季节后，血清25（OH）D浓度与肺功能呈正相关。25（OH）D上四分位数与下四分位数之间FEV1和FVC的差异分别为51ml（标准误（SE），17ml，P＜0.001）和58ml（SE，20ml，P＜0.005）。在校正体重指数、生活方式和社会经济因素、以及呼吸系统疾病后，血清25（OH）D与FEV1和FVC的相关性仅稍微减弱。伴有肺结核病史的受试者FEV1增加更多，在25（OH）D上四分位数和下四分位数之间的差异为229ml（SE，87ml，P＜0.01）。
该研究发现，血清25（OH）D水平与肺功能呈正相关，这种关系在肺结核易感人群表现的更加突出。

Relationship between serum 25-hydroxyvitamin D and lung function among Korean adults in Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2010.
CONTEXT
The relationship between vitamin D status and pulmonary function has not been investigated for an East Asian population.
OBJECTIVE
The aim of the present study was to examine the relationship of serum 25-hydroxyvitamin D [25(OH)D] with lung function in Korean adults.
DESIGN AND SETTING
The analysis used data from the Korea National Health and Nutrition Examination Survey (KNHANES), a cross-sectional survey of Korean civilians, conducted from 2008 to 2010.
PARTICIPANTS
A total of 10 096 people aged 19 years and older were selected from 16 administrative districts in South Korea.
MAIN OUTCOME MEASURES
Serum 25(OH)D levels with lung function [forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC)].
RESULTS
Serum 25(OH)D concentration was positively associated with lung function after controlling for age, sex, height, and season. For FEV1 and FVC, the differences between top and bottom quartiles in 25(OH)D were 51 mL (SE, 17 mL, P trend <.001) and 58 mL (SE, 20 mL, P trend <.005) greater volume, respectively. Association of serum 25(OH)D with FEV1 and FVC was only slightly attenuated after adjustment for body mass index, lifestyle and socioeconomic factors, and respiratory illness. The subjects with a history of pulmonary tuberculosis showed a much higher increase in FEV1; the difference between top and bottom quartiles in 25(OH)D was 229 mL (SE, 87 mL, P trend <.01).
CONCLUSION
Serum 25(OH)D levels have a positive correlation with pulmonary function. This relationship appears prominent in subjects with susceptibility to pulmonary tuberculosis.