PLoS One：妊娠期左心房功能的可逆变化

2015-05-05 Mechront 译 MedSci原创

妊娠后，母体为了适应胎儿的发育生长全身各系统均发生一系列生理变化，以适应不断增加的生理负担的需要，并持续整个妊娠期，比如心血管系统会表现出血容量的增加，至妊娠32～34周达高峰，维持此水平至分娩；血液处于相对贫血状态和高凝状态；心脏负担明显加重等。

妊娠后，母体为了适应胎儿的发育生长全身各系统均发生一系列生理变化，以适应不断增加的生理负担的需要，并持续整个妊娠期，比如心血管系统会表现出血容量的增加，至妊娠32～34周达高峰，维持此水平至分娩；血液处于相对贫血状态和高凝状态；心脏负担明显加重等。

有研究报道怀孕期间左心室舒张功能受损，但是左心房(LA)功能的变化尚不清楚。因此Song
G通过二维斑点追踪超声心动图(2DSTE)评估怀孕期间左心房(LA)功能的变化。

共有50个怀孕和50名健康未生育过的妇女(对照组)参加本研究。对所有孕妇随访到产后第六个月。通过Simpson法得到LA最大容积、LA最小容积、LA收缩量等数据。研究者计算了LA充盈量、LA扩张指数、LA射血分数、被动容积、被动排空指数、主动容积、主动排空指数等指标。通过2DSTE得到纵向的LA收缩期峰值应变(SS)、收缩期应变率(s-SR)、早期舒张压应变率(e-SR)、舒张末应变率(a-SR)等数据。

与对照组相比,，孕妇左心房(LA)储存功能增加(P<0.05)，导管功能下降(P<0.05)，辅助泵功能增加(P<0.05)。对照组和产后组无统计学差异。

研究结果表明，通过二维斑点追踪超声心动图(2DSTE)发现怀孕期间左心房(LA)储存功能和辅助泵功能增加，但是导管功能下降；并且这些改变是可逆的，将在产后恢复至妊娠前状态。

原始出处：

Song G, Liu J, Ren W, et al. Reversible Changes of Left Atrial Function
during Pregnancy Assessed by Two-Dimensional Speckle Tracking Echocardiography.
PLoS One. 2015. 10(5): e0125347.

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2016-02-01 ylz8411

#左心房#

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2015-05-07 wjcjjian

#妊娠期#

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2015-05-07 ms5880526374914242

#左心房功能#

64 0
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2015-05-07 sodoo

#心房#

75 0
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2015-05-06 chaie1217

不错啊

125 0
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2015-05-06 sumer

这文章的设计很简单，难得的是作者想到了

141 0
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2015-05-06 lcrzl

这个文章贴近临床，非常好

232 0

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