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禽流感(H7N9)的真相

2017-03-14 佚名 medicalxpress

2017年2月,在三个患者中检测到一种新的A(H7N9)病毒,表明家禽中存在高致病性。这是一个需要监测的重要结果,然而,ECDC得出的结论认为,由于没有证据表明人与人之间的传播,通过人类在欧洲传播疾病的风险仍然很低。虽然A(H7N9)的遗传变化可能对家禽有影响,到目前为止,没有证据表明人对人的传播性。自2013年3月31日发出新型重配甲型流感(H7N9)病毒以来,已报告1258宗实验室确诊的禽流感

2017年2月,在三个患者中检测到一种新的A(H7N9)病毒,表明家禽中存在高致病性。这是一个需要监测的重要结果,然而,ECDC得出的结论认为,由于没有证据表明人与人之间的传播,通过人类在欧洲传播疾病的风险仍然很低。虽然A(H7N9)的遗传变化可能对家禽有影响,到目前为止,没有证据表明人对人的传播性。



自2013年3月31日发出新型重配甲型流感(H7N9)病毒以来,已报告1258宗实验室确诊的禽流感(H7N9)病毒感染个案。人类病例由A(H7N9)感染引起。在这个浪潮期间,人类病例的数量已经高于以前,占据到目前为止报告的人类病例的37%。这很可能是由于活禽市场上的环境污染和病毒在家禽中的流通增加引起的。

2017年2月,在广东省的两名病人和一名到台湾的病人中检测到一种在血凝素基因中具有的突变的新A(H7N9)病毒,其在家禽中具有高致病性。然而,在目前一个省份证实的460例人类病例中,仅有三例检测到这种新病毒。目前还不清楚新出现的高致病性禽流感(HPAI)病毒A(H7N9)是否将取代低致病性病毒,或者是否两者将在鸟群中共同循环。

在最近的世卫组织流感疫苗组合物会议上提出的证据显示,新出现的和一些目前循环的A(H7N9)病毒在遗传上和抗原上不同于目前的A(H7N9)候选疫苗病毒。为了解决这个问题,提出了新的A(H7N9)候选疫苗病毒。此外,这三个患者中的HPAI A(H7N9)菌株在与神经氨酸酶抑制剂的易感性降低相关的神经氨酸酶(NA)基因中呈现突变。在三种患者的抗病毒治疗期间可能出现与对神经氨酸酶抑制剂的抗性相关的突变。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=219438, encodeId=0a3c21943805, content=在最近的世卫组织流感疫苗组合物会议上提出的证据显示,新出现的和一些目前循环的A(H7N9)病毒在遗传上和抗原上不同于目前的A(H7N9)候选疫苗病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Fri Jul 07 09:04:39 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180591, encodeId=6e00180591df, content=新知识学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Mar 17 10:56:59 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477528, encodeId=b55d14e752818, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Thu Mar 16 05:47:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180049, encodeId=ce9518004971, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Mar 15 10:10:05 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179933, encodeId=50c61e99336e, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Mar 15 05:53:52 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-07-07 Julie W

    在最近的世卫组织流感疫苗组合物会议上提出的证据显示,新出现的和一些目前循环的A(H7N9)病毒在遗传上和抗原上不同于目前的A(H7N9)候选疫苗病毒。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=219438, encodeId=0a3c21943805, content=在最近的世卫组织流感疫苗组合物会议上提出的证据显示,新出现的和一些目前循环的A(H7N9)病毒在遗传上和抗原上不同于目前的A(H7N9)候选疫苗病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Fri Jul 07 09:04:39 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180591, encodeId=6e00180591df, content=新知识学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Mar 17 10:56:59 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477528, encodeId=b55d14e752818, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Thu Mar 16 05:47:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180049, encodeId=ce9518004971, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Mar 15 10:10:05 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179933, encodeId=50c61e99336e, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Mar 15 05:53:52 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-17 大爰

    新知识学习了!

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=219438, encodeId=0a3c21943805, content=在最近的世卫组织流感疫苗组合物会议上提出的证据显示,新出现的和一些目前循环的A(H7N9)病毒在遗传上和抗原上不同于目前的A(H7N9)候选疫苗病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Fri Jul 07 09:04:39 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180591, encodeId=6e00180591df, content=新知识学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Mar 17 10:56:59 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477528, encodeId=b55d14e752818, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Thu Mar 16 05:47:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180049, encodeId=ce9518004971, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Mar 15 10:10:05 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179933, encodeId=50c61e99336e, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Mar 15 05:53:52 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=219438, encodeId=0a3c21943805, content=在最近的世卫组织流感疫苗组合物会议上提出的证据显示,新出现的和一些目前循环的A(H7N9)病毒在遗传上和抗原上不同于目前的A(H7N9)候选疫苗病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Fri Jul 07 09:04:39 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180591, encodeId=6e00180591df, content=新知识学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Mar 17 10:56:59 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477528, encodeId=b55d14e752818, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Thu Mar 16 05:47:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180049, encodeId=ce9518004971, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Mar 15 10:10:05 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179933, encodeId=50c61e99336e, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Mar 15 05:53:52 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-15 ylzr123

    好文,值得点赞,更值得收藏!慢慢领会学习的。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=219438, encodeId=0a3c21943805, content=在最近的世卫组织流感疫苗组合物会议上提出的证据显示,新出现的和一些目前循环的A(H7N9)病毒在遗传上和抗原上不同于目前的A(H7N9)候选疫苗病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Fri Jul 07 09:04:39 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180591, encodeId=6e00180591df, content=新知识学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Mar 17 10:56:59 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477528, encodeId=b55d14e752818, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Thu Mar 16 05:47:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180049, encodeId=ce9518004971, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Mar 15 10:10:05 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179933, encodeId=50c61e99336e, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Mar 15 05:53:52 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-15 stupidox

    很有意义

    0

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2016年3月13日,湖北省确诊一例由邻近省份输入的H7N9流感并伴重症肺炎、严重脓毒血症并多器官功能衰竭(急性呼吸窘迫综合征、感染性休克、肝肾功能受损)多囊肾、多囊肝病例,从事禽类经营活动。 省卫生计生委对此高度重视,已采取隔离救治病人、管理密切接触者、强化疫情监测和健康教育等防控措施。 专家研判认为:春季为H7N9流感的多发期,当前该病的流行特征和病原学生物特性没有改变,尚不具备人传人条件

禽流感生猛来袭,这几个药企值得你关注!

春季本是万物复苏、生机勃勃的时节,然而,近日却由于H7N9禽流感的侵袭而蒙上了一层阴影。H7N9禽流感已不是初来乍到,然而今年似乎尤为生猛。与禽流感相关的上市药企也在近日备受关注,又“火”了一把。

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