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Radiology:二胎时代到来,MR成像可用来评估胎儿生长受限!

2017-07-15 shaosai MedSci原创

二胎时代到来,临床工作中对于孕产妇的检查越来越不拘泥于超声检查,MR检查技术的更新越来越能满足临床对于患者检查目的的需要。研究人员利用氧增强和血氧水平依赖性(BOLD)磁共振(MR)成像参数评价在正常胎儿和胎儿生长限制(FGR)的孕妇中胎盘的差异,进而探究MR对FGR检出率的价值,并将结果发表在影像学权威杂志Radiology上。

二胎时代到来,临床工作中对于孕产妇的检查越来越不拘泥于超声检查,MR检查技术的更新越来越能满足临床对于患者检查目的的需要。研究人员利用氧增强和血氧水平依赖性(BOLD)磁共振(MR)成像参数评价在正常胎儿和胎儿生长限制(FGR)的孕妇中胎盘的差异,进而探究MR对FGR检出率的价值,并将结果发表在影像学权威杂志Radiology上。

本病例对照研究自2010年10月至2015年10月共纳入了28例非复杂妊娠妇女(个体化出生体重比例[IBR]>第20百分位数和生产时孕周> 37周),23例孕妇伴随FGR(IBR <5百分位数和超声检查结果异常[US])并行 MR成像。给予受试者呼吸空气或氧气来分析定量胎盘纵向R1(1 / T1)和横向R2 *(1 / T2 *)的差异。ΔR1为吸氧后的氧分压变化(ΔPo2)。采用非配对T检验分析两组间干预差异。以胎龄作为协变量建立logistic回归诊断模型。

正常妊娠孕妇胎盘平均基线R1和R2 *(R1:0.59s-1,95%[CI]:0.58 s-1,0.60秒-1; R2 *:17 s-1,95%CI:14 s-1,20 s-1)与合并FGR妊娠的孕妇(R1:0.63 s-1,95%CI:0.62 s-1 0.65 s-1; R2 *:26 s-1,95% CI:22 s-1,32 s-1)(P <.0001)。在所有受试者中ΔR1与胎龄显着负相关(P <0.0001),FGR组的ΔR1要明显低于正常孕妇组,差异有统计学意义(P = .003)。FGR与正常妊娠受试者的ΔPo2、 基线 R1和R2*曲线下面积(ROC)为0.91(95%CI:0.82,0.99)。

正常妊娠和合并重度FGR孕妇的R1,R2 *和ΔPo2间差异有显着性。利用MR成像参数有助于识别与FGR相关的胎盘功能障碍,并且在临床工作中有助于准确鉴别FGR和因胎龄小而体积小的正常胎儿。

原始出处:

Emma Ingram, David Morris, Josephine Naish,et al,MR Imaging Measurements of Altered Placental Oxygenation in Pregnancies Complicated by Fetal Growth Restriction. Radiology. 2017.DOI:10.1148/radiol.2017162385

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    2017-07-15 惠映实验室

    学习了,谢谢

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1417951, encodeId=76e5141e95173, content=<a href='/topic/show?id=70988361670' target=_blank style='color:#2F92EE;'>#胎儿生长受限#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83616, encryptionId=70988361670, topicName=胎儿生长受限)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=073b3313558, createdName=fanweitanzhen, createdTime=Mon Jul 17 03:09:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480222, encodeId=788c1480222be, content=<a href='/topic/show?id=d47d2404839' target=_blank style='color:#2F92EE;'>#二胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24048, encryptionId=d47d2404839, topicName=二胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a257628025, createdName=ms1065684921169360, createdTime=Mon Jul 17 03:09:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222620, encodeId=9919222620b5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Jul 15 15:27:40 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222586, encodeId=7f722225864f, content=MRI评价胎儿发育有很大优势, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Sat Jul 15 12:24:06 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222583, encodeId=24692225833c, content=好的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sat Jul 15 12:20:10 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 邓启付

    MRI评价胎儿发育有很大优势

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1417951, encodeId=76e5141e95173, content=<a href='/topic/show?id=70988361670' target=_blank style='color:#2F92EE;'>#胎儿生长受限#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83616, encryptionId=70988361670, topicName=胎儿生长受限)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=073b3313558, createdName=fanweitanzhen, createdTime=Mon Jul 17 03:09:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480222, encodeId=788c1480222be, content=<a href='/topic/show?id=d47d2404839' target=_blank style='color:#2F92EE;'>#二胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24048, encryptionId=d47d2404839, topicName=二胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a257628025, createdName=ms1065684921169360, createdTime=Mon Jul 17 03:09:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222620, encodeId=9919222620b5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Jul 15 15:27:40 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222586, encodeId=7f722225864f, content=MRI评价胎儿发育有很大优势, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Sat Jul 15 12:24:06 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222583, encodeId=24692225833c, content=好的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sat Jul 15 12:20:10 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 Drhzm308

    好的,学习了

    0

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近期,一项发表在杂志Diabetes Care上的研究使用目标代谢组学来确定母体BMI和葡萄糖水平与脐带血代谢物以及脐带血代谢物与新生儿出生体重和母亲后代胎儿肥胖的关系。此项研究对来自欧洲血统、非洲裔加勒比海、泰国和墨西哥裔美国的新生儿(每个祖谱系的400名),其母亲参加高血糖和不良妊娠结局(HAPO)的研究,脐血样本进行靶向代谢组学测定,他哦你是进行了出生时的人体测量。此项研究结果显示:除了甘油

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