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Stroke:颈动脉支架置入术后平均血小板体积不能预测白人患者再狭窄

2019-12-23 xing.T MedSci原创

由此可见,该研究没有确定MPV是白人患者CAS后ISR的危险因素。戒烟是避免这种并发症的重要措施。

平均血小板体积(MPV)表示血小板活动情况,其可能会影响患者进展性动脉粥样硬化疾病的风险。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,这研究发现,在中国人群中,颈动脉支架置入术(CAS)后MPV升高是支架内再狭窄(ISR)的预测因子。但是,在白人中,CAS后MPV在ISR发生中的作用尚不清楚。

研究人员回顾性地分析了2005年至2017年期间在研究者所在中心接受CAS的动脉粥样硬化疾病患者。所有患者均在CAS术后1、3、6个月以及每年进行临床和二维超声成像检查。ISR被定义为治疗血管中狭窄度≥50%(NASCET [北美有症状性颈动脉内膜切除术试验]标准)。在CAS之前、最后一次随访以及ISR检测时对MPV进行了评估。

在392例CAS患者(平均年龄为68.5±9.5岁,女性为26.8%,症状性狭窄为42.3%)中,有54例患者在平均随访32个月后发生了ISR。与非ISR患者相比,ISR患者的基线MPV并无差异(10.7 vs. 10.6 fL,P=0.316)。从基线到ISR检测,MPV水平也没有变化(P=0.310),并且与卒中复发或血管事件无关(P>0.5)。多变量分析确定主动吸烟是颈动脉ISR的唯一危险因素(比值比为2.53 [95%CI为1.21-5.29])。

由此可见,该研究没有确定MPV是白人患者CAS后ISR的危险因素。戒烟是避免这种并发症的重要措施。

原始出处:

Melanie Haidegger.et al.Mean Platelet Volume Does Not Predict Restenosis After Carotid Artery Stenting in Whites.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028180

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    2019-12-24 txqjm

    谢谢了,学习

    0

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