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J Clin Invest：研究揭开了IFN-γ介导的肠道血管激活在IBD中的致病影响

2020-09-28 MedSci原创 MedSci原创

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炎症性肠病（IBD）是一种慢性炎症性疾病，发病率不断上升。病变组织有大量的血管，然而血管在IBD中的致病影响和潜在的调节机制尚未可知，研究结果已在线发表于J Clin Invest。

炎症性肠病（IBD）是一种慢性炎症性疾病，发病率不断上升。病变组织有大量的血管，然而血管在IBD中的致病影响和潜在的调节机制尚未可知，研究结果已在线发表于J Clin Invest。

IFN-γ是IBD发病过程中的主要细胞因子，但在该病的背景下，人们考虑的几乎只是其免疫调节和上皮细胞导向功能。我们小组最近的研究表明，IFN-γ对血管也有强大的作用。基于这些考虑，我们分析了IFN-γ的血管导向致病功能，发现其通过破坏血管屏障来驱动IBD的发病。

 

具体来说，我们表明，通过内皮特异性敲除IFN-γ受体2抑制血管中的IFN-γ反应，可以改善实验诱导的小鼠结肠炎。IFN-γ通过破坏粘连结蛋白VE-cadherin，导致血管屏障的破坏，从而起到致病作用。值得注意的是，在人类IBD患者中也证实了肠道血管屏障功能障碍，支持我们的研究结果的临床意义。使用伊马替尼治疗可以恢复VE-cadherin/adherens交界，抑制血管通透性，并显著降低实验性结肠炎的结肠炎症。

总之，该研究结果揭开了IFN-γ介导的肠道血管激活在IBD中的致病影响，并为该疾病的血管导向治疗开辟了新的途径。

 

原始出处：

 

Victoria Langer, Eugenia Vivi, et al., IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption. J Clin Invest. 2019 Nov 1;129(11):4691-4707. doi: 10.1172/JCI124884.

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    2021-08-12 xiangyuzhou971

    #EST#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2051606, encodeId=6abd205160623, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Thu Aug 12 03:53:27 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263598, encodeId=0b2a12635989e, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Sep 30 06:53:27 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519057, encodeId=8b0b151905efa, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Wed Sep 30 06:53:27 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888960, encodeId=3c6088896075, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210206/e9c8a3a1ec0d4eec93e90dd45673c888/f1c3a6a225f74f0f9bfc97e63edcd7a8.jpg, createdBy=fe9c5089418, createdName=145cd6eem24暂无昵称, createdTime=Mon Sep 28 18:02:01 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888953, encodeId=196988895357, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Sep 28 17:04:51 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888942, encodeId=687088894266, content=看来还是和肠道血管通透性有关!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4a5341614, createdName=ms4000001445704097, createdTime=Mon Sep 28 16:26:33 CST 2020, time=2020-09-28, status=1, ipAttribution=)]
    2020-09-30 bnurmamat

    #IBD#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2051606, encodeId=6abd205160623, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Thu Aug 12 03:53:27 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263598, encodeId=0b2a12635989e, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Sep 30 06:53:27 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519057, encodeId=8b0b151905efa, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Wed Sep 30 06:53:27 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888960, encodeId=3c6088896075, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210206/e9c8a3a1ec0d4eec93e90dd45673c888/f1c3a6a225f74f0f9bfc97e63edcd7a8.jpg, createdBy=fe9c5089418, createdName=145cd6eem24暂无昵称, createdTime=Mon Sep 28 18:02:01 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888953, encodeId=196988895357, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Sep 28 17:04:51 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888942, encodeId=687088894266, content=看来还是和肠道血管通透性有关!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4a5341614, createdName=ms4000001445704097, createdTime=Mon Sep 28 16:26:33 CST 2020, time=2020-09-28, status=1, ipAttribution=)]
    2020-09-30 bugit

    #IFN#

    0

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    2020-09-28 145cd6eem24暂无昵称

    👍

    0

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    2020-09-28 wxl882001

    了解

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2051606, encodeId=6abd205160623, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Thu Aug 12 03:53:27 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263598, encodeId=0b2a12635989e, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Sep 30 06:53:27 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519057, encodeId=8b0b151905efa, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Wed Sep 30 06:53:27 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888960, encodeId=3c6088896075, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210206/e9c8a3a1ec0d4eec93e90dd45673c888/f1c3a6a225f74f0f9bfc97e63edcd7a8.jpg, createdBy=fe9c5089418, createdName=145cd6eem24暂无昵称, createdTime=Mon Sep 28 18:02:01 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888953, encodeId=196988895357, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Sep 28 17:04:51 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888942, encodeId=687088894266, content=看来还是和肠道血管通透性有关!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4a5341614, createdName=ms4000001445704097, createdTime=Mon Sep 28 16:26:33 CST 2020, time=2020-09-28, status=1, ipAttribution=)]
    2020-09-28 ms4000001445704097

    看来还是和肠道血管通透性有关!

    0

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