Baidu
map

JNNP:自身免疫性疾病的癫痫发作起源:多中心回顾性研究

2020-09-11 MedSci原创 MedSci原创

在过去的几十年中,自身抗体因素已成为原本无法解释的癫痫病的根本原因,并提示了自身免疫 和癫痫病之间的联系。除了由炎症引起的癫痫发作易感性增加外,许多特定的自身抗体还具有直接的致癫痫作用。在这些基础上,

在过去的几十年中,自身抗体因素已成为原本无法解释的癫痫病的根本原因,并提示了自身免疫 和癫痫病之间的联系。除了由炎症引起的癫痫发作易感性增加外,许多特定的自身抗体还具有直接的致癫痫作用。在这些基础上,国际抗癫痫联盟(ILAE)在最新分类中引入了“免疫病因学癫痫”的新概念,指的是癫痫病直接源于癫痫的患者。在最近报告 中,病因不明的癫痫患者中有11%至20.5%的患者对特定抗体呈阳性反应。 由于不断发现与癫痫相关的自身抗体而导致的结果症状

方法:作者回顾性收集2014年1月至2019年7月在维罗纳和萨尔茨堡神经内科转诊的92例新发病型癫痫,癫痫持续状态或病因不明的慢性癫痫患者的92例临床和临床资料。在成对的血清/脑脊液(CSF)中进行基于固定和活细胞的测定,基于组织的测定,免疫印迹和大鼠海马活细胞培养,以检测抗神经胶质和抗神经胶质抗体。然后计算APE2和RITE2得分,并将其与临床和实验室数据进行比较。

结果:在29/92例患者中检测到自身抗体(31.5%),在6/29例中观察到多阳性。 APE2评分(中位数5,范围1–15)与抗体阳性率显着相关(p = 0.014),尤其是对于存在神经精神症状(p <0.01),运动障碍(p <0.01),自主神经发育不良(p = 0.03)的患者,臂肱运动障碍(p = 0.03)和癌症病史(p <0.01)。抗体阴性患者的癫痫持续状态明显更高(p <0.01)。在RITE2评分项目中,免疫治疗的早期启动与良好的治疗反应相关(p = 0.001),而无反应者的癌症病史明显更为普遍(p <0.01)。至少1年后,神经精神症状和癫痫发作的持续性与抗癫痫药的维持有关。

 

作者的研究有一些局限性要考虑,包括回顾性设计,不全面的随访和多中心方法,这可能会影响临床数据的分析,治疗选择和结果测量。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (12)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-24 ms3000001121456932

    学习

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-12 146465bem06暂无昵称

    癫痫起源

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 1475877fm90暂无昵称

    学到了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 神盾医疗局局长Jack

    #癫痫#该研究存在局限

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 1e145228m78(暂无匿称)

    好文

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 笑西风2019

    学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1904029, encodeId=c4f01904029c9, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 05 20:11:59 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887962, encodeId=934488e9626a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png;jsessionid=23017AF9A43E478B081BD06235BF844F, createdBy=e98c5416040, createdName=ms3000001121456932, createdTime=Thu Sep 24 14:37:53 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580171, encodeId=9c3415801e131, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585706, encodeId=49e21585e0687, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Sat Sep 12 15:11:59 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884725, encodeId=62dc884e25ff, content=癫痫起源, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Sep 12 11:11:00 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884496, encodeId=e03788449690, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c495209553, createdName=1475877fm90暂无昵称, createdTime=Fri Sep 11 10:07:58 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884490, encodeId=7af18844902e, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>该研究存在局限, beContent=null, objectType=article, channel=null, level=null, likeNumber=263, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Sep 11 09:52:41 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884484, encodeId=fe0788448465, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Sep 11 09:34:03 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884474, encodeId=74f48844e4a9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Fri Sep 11 09:12:04 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884438, encodeId=77ea88443862, content=<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=244, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 08:43:31 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 lovetcm

相关资讯

罗氏2款新药在中国获批临床:CD3/CD20双抗、C5单抗

9月9日,罗氏2款新药在中国获批临床,分别为CD3/CD20双抗RO7082859(弥漫性大B细胞淋巴瘤)和C5单抗RO7112689(阵发性睡眠性血红蛋白尿患者)。

先声药业「艾拉莫德片」治疗原发性干燥综合征临床申请获批

9月8日,先声药业研发的抗风湿新药艾拉莫德片(商品名:艾得辛?)用于治疗原发性干燥综合征(pSS)的新药临床试验申请(受理号CXHL2000340/1/2)获得批准。艾拉莫德片于2011年在全球率先上

面向全球引进人才!清华大学临床医学院发出招贤帖

清华大学临床医学院9日启动全球人才招聘计划,期待能引进海内外高层次医学及相关学科人才。

临床研究报告受理要求新变化:不再要求提交分中心报告

日前,国家药监局药审中心发布《关于临床研究报告受理要求的说明》(以下简称说明),值得关注的是,《说明》提出与之前受理审查指南相比,不再要求提交分中心报告。

因志愿者出现疑似严重不良反应,阿斯利康暂停新冠疫苗三期临床试验

当地时间8日,阿斯利康宣布,该公司将暂停一项正在进行的新冠病毒疫苗试验研究,原因是一名志愿者出现疑似严重的不良反应,这也是首个宣布暂停的已进入三期临床试验的新冠候选疫苗。

沉默IL-6表达!优卡迪创新型CAR-T产品获批临床

日前,位于张江科学城的细胞治疗企业上海优卡迪生物医药科技有限公司(以下简称“优卡迪”)的在研产品——具有沉默白介素6表达功能的靶向CD19基因工程化自体

Baidu
map
Baidu
map
Baidu
map