Baidu
map

JAMA Neurol:阿兹海默症发病前15至20年大脑中就已存在迹象!

2018-01-30 Heather_z727 来宝网

华盛顿大学睡眠专家领导了一个研究小组,发现记忆完整的人脑部扫描显示出更多的临床前证据。

【阿尔茨海默氏症患者记忆丧失前数年生物钟中断】华盛顿大学睡眠专家领导了一个研究小组,发现记忆完整的人脑部扫描显示出更多的临床前证据。

众所周知,阿尔茨海默氏症患者体内生物钟紊乱,觉醒周期可能增加患这种疾病的风险。圣路易斯华盛顿大学医学院的一项新研究表明,这种昼夜节律紊乱可以作为阿兹海默症的临床前证据。

这些发现可能会帮助医生更早地识别出阿尔茨海默氏症的风险人群。这一点很重要,因为阿尔茨海默氏症的损害在临床症状出现前的15年到20年就会在大脑中生根。这项研究发表在《JAMA神经病学》杂志上。

“这并不是因为研究中的人缺乏睡眠,但他们的睡眠往往是零碎的,晚上睡八个小时和白天打盹时一小时一次地睡八小时是大相径庭的。”研究人员还在老鼠身上进行了一项单独的研究,该研究发表在《实验医学杂志》上。研究表明,类似的昼夜节律干扰会加速大脑中淀粉样斑块的发育,而淀粉样斑块与阿尔茨海默氏症有关。

华盛顿大学之前对人类和动物进行的研究发现,淀粉样蛋白的水平在白天和晚上以可预测的方式波动。睡眠过程中淀粉样蛋白水平下降,一些研究表明,当睡眠中断或睡眠不足时,淀粉样蛋白水平会增加。

“在这项新的研究中,我们发现临床前阿尔茨海默病患者的昼夜活动模式更加分散,白天不活动或睡眠时间更长,晚上的活动时间更长。”

原始出处:

Musiek, ES, Bhimasani M, Zangrilli MA,et al. Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease. JAMA Neurology (2018). DOI: 10.1001/jamaneurol.2017.4719.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2000286, encodeId=cbb6200028667, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 03 19:43:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339912, encodeId=8b16339912e5, content=也就是说日夜颠倒,熬夜就。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/07/31/88b7a0fe36b7bac9361f6feb3f050afa.jpg, createdBy=674d2404499, createdName=asuraxia, createdTime=Tue Aug 21 12:36:30 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465351, encodeId=0ca11465351d8, content=<a href='/topic/show?id=78829e719a0' target=_blank style='color:#2F92EE;'>#阿兹海默症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97719, encryptionId=78829e719a0, topicName=阿兹海默症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e96710983, createdName=jiekemin, createdTime=Thu Feb 01 02:43:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283517, encodeId=17c028351eae, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Jan 30 13:11:06 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283508, encodeId=12ea2835089c, content=学习丁, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5171668917, createdName=坚强007, createdTime=Tue Jan 30 12:06:53 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-04-03 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=2000286, encodeId=cbb6200028667, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 03 19:43:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339912, encodeId=8b16339912e5, content=也就是说日夜颠倒,熬夜就。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/07/31/88b7a0fe36b7bac9361f6feb3f050afa.jpg, createdBy=674d2404499, createdName=asuraxia, createdTime=Tue Aug 21 12:36:30 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465351, encodeId=0ca11465351d8, content=<a href='/topic/show?id=78829e719a0' target=_blank style='color:#2F92EE;'>#阿兹海默症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97719, encryptionId=78829e719a0, topicName=阿兹海默症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e96710983, createdName=jiekemin, createdTime=Thu Feb 01 02:43:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283517, encodeId=17c028351eae, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Jan 30 13:11:06 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283508, encodeId=12ea2835089c, content=学习丁, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5171668917, createdName=坚强007, createdTime=Tue Jan 30 12:06:53 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-08-21 asuraxia

    也就是说日夜颠倒,熬夜就。。。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2000286, encodeId=cbb6200028667, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 03 19:43:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339912, encodeId=8b16339912e5, content=也就是说日夜颠倒,熬夜就。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/07/31/88b7a0fe36b7bac9361f6feb3f050afa.jpg, createdBy=674d2404499, createdName=asuraxia, createdTime=Tue Aug 21 12:36:30 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465351, encodeId=0ca11465351d8, content=<a href='/topic/show?id=78829e719a0' target=_blank style='color:#2F92EE;'>#阿兹海默症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97719, encryptionId=78829e719a0, topicName=阿兹海默症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e96710983, createdName=jiekemin, createdTime=Thu Feb 01 02:43:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283517, encodeId=17c028351eae, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Jan 30 13:11:06 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283508, encodeId=12ea2835089c, content=学习丁, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5171668917, createdName=坚强007, createdTime=Tue Jan 30 12:06:53 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2000286, encodeId=cbb6200028667, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 03 19:43:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339912, encodeId=8b16339912e5, content=也就是说日夜颠倒,熬夜就。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/07/31/88b7a0fe36b7bac9361f6feb3f050afa.jpg, createdBy=674d2404499, createdName=asuraxia, createdTime=Tue Aug 21 12:36:30 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465351, encodeId=0ca11465351d8, content=<a href='/topic/show?id=78829e719a0' target=_blank style='color:#2F92EE;'>#阿兹海默症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97719, encryptionId=78829e719a0, topicName=阿兹海默症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e96710983, createdName=jiekemin, createdTime=Thu Feb 01 02:43:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283517, encodeId=17c028351eae, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Jan 30 13:11:06 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283508, encodeId=12ea2835089c, content=学习丁, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5171668917, createdName=坚强007, createdTime=Tue Jan 30 12:06:53 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 Y—xianghai

    学习了新知识

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2000286, encodeId=cbb6200028667, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 03 19:43:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339912, encodeId=8b16339912e5, content=也就是说日夜颠倒,熬夜就。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/07/31/88b7a0fe36b7bac9361f6feb3f050afa.jpg, createdBy=674d2404499, createdName=asuraxia, createdTime=Tue Aug 21 12:36:30 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465351, encodeId=0ca11465351d8, content=<a href='/topic/show?id=78829e719a0' target=_blank style='color:#2F92EE;'>#阿兹海默症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97719, encryptionId=78829e719a0, topicName=阿兹海默症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e96710983, createdName=jiekemin, createdTime=Thu Feb 01 02:43:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283517, encodeId=17c028351eae, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Jan 30 13:11:06 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283508, encodeId=12ea2835089c, content=学习丁, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5171668917, createdName=坚强007, createdTime=Tue Jan 30 12:06:53 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 坚强007

    学习丁

    0

相关资讯

重复 Am J Geriat Psychiat:姜黄素,能改善记忆力和情绪,可能对阿尔兹海默病变有潜在作用

姜黄素(curcumin)是提取自姜科、天南星科中一些植物根茎中的一种化学成分,最初被证实具有抗炎症、抗氧化的作用。它被认为是印度老年人阿尔兹海默症患病率低、认知能力较好的一个可能原因,这是因为姜黄素正是印度饮食中最常用的添加剂(增加咖喱等食物的色彩)。

ALZHEIMERS DEMENT:科学家预测阿尔兹海默增长趋势

随着全球老龄化的进程,阿尔兹海默病成了社会关注的重点。近日,来自加州大学的研究人员预测了临床前和临床阿尔茨海默病(AD)的患病率,并评估美国一级和二级预防的潜在影响。

AM J RESP CRIT CARE:睡眠呼吸暂停和阿尔兹海默相关

已有的研究表明,阻塞性睡眠呼吸暂停(OSA)可能是发展为轻度认知功能障碍和阿尔茨海默病的风险因素。但是至今为止,睡眠呼吸暂停如何影响阿尔茨海默病的纵向风险还不太清楚。

Aging Cell:分子J147成功逆转小鼠痴呆症,阿兹海默症人体试验引关注!

SAK研究所实验药物J147是生命的现代酏剂;它被证明用于治疗阿尔茨海默病和小鼠的反向衰老,并且几乎准备用于人类的临床试验。

Nature:靶向线粒体治疗阿尔兹海默

阿尔茨海默病是一种以淀粉样蛋白-β肽聚集为特征的常见且具有破坏性的疾病。然而,至今为止,我们对阿尔茨海默病的潜在分子机制或如何治疗这类患者还知之甚少。 来自洛桑联邦理工学院的研究人员提供了生物信息学和实验证据,表明线粒体应激反应信号存在于涉及人类,小鼠和秀丽隐杆线虫的淀粉样蛋白-β蛋白毒性的疾病中。这些疾病还涉及线粒体未折叠蛋白反应和线粒体自噬过程。 研究人员使用具有淀粉样蛋白-β毒性的蠕虫模

Mol Psychiatry:阿尔兹海默症“会转移”!竟是一种全身疾病!

长期以来,我们认为阿尔兹海默症是一个脑疾病,科学家也针对这种情况进行了各种治疗。但是近来我们发现,这些治疗手段,效果缺缺。就在昨日《Molecular Psychiatry》发表了一篇文章:阿尔兹海默症可能和癌症一样,是会转移的!并不单单是脑部疾病,更可能是全身性疾病!

Baidu
map
Baidu
map
Baidu
map