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Stem Cell Res Ther:Chrysosplenetin可对抗雌激素缺乏所诱导的骨丧失

2019-08-30 不详 网络

Chrysosplenetin是从植物Chamomilla recutita和Laggera pterodonta中分离的O-甲基化黄酮醇化合物。本研究旨在评估Chrysosplenetin对人源性骨髓基质细胞(hBMSCs)成骨的作用以及通过Wnt/β-catenin信号通路抑制雌激素缺乏引起的骨质疏松症。存在或不存在Wnt抑制剂dickkopf相关蛋白1(DKK1)或骨形态发生蛋白2(BMP2

Chrysosplenetin是从植物Chamomilla recutita和Laggera pterodonta中分离的O-甲基化黄酮醇化合物。本研究旨在评估Chrysosplenetin对人源性骨髓基质细胞(hBMSCs)成骨的作用以及通过Wnt/β-catenin信号通路抑制雌激素缺乏引起的骨质疏松症。

存在或不存在Wnt抑制剂dickkopf相关蛋白1(DKK1)或骨形态发生蛋白2(BMP2)拮抗剂Noggin的情况下,通过Chrysosplenetin培养和处理hBMSCs。使用RT-qPCR鉴定Wnt/β-连环蛋白通路和成骨细胞特异性标志物的靶基因的表达。通过蛋白质印迹和免疫荧光染色测量β-连环蛋白的情况。建立卵巢切除(OVX)小鼠模型以通过注射Chrysosplenetin来检测骨丢失抑制。进行Micro-CT和组织学测定以评估骨基质和成骨细胞数量的保护。通过ELISA检测与骨生成相关的血清标志物。

结果显示,Chrysosplenetin时间依赖性地促进hBMSCs的增殖和成骨细胞生成,在10μM浓度下达到其最大效应。通过Chrysosplenetin处理增强了Wnt/β-catenin通路的靶基因和成骨细胞特异性标记基因的表达。此外,Chrysosplenetin处理β-连环蛋白的磷酸化降低,并且促进β-连环蛋白的核转位。上述成骨作用被DKK1或BMP2拮抗剂Noggin阻断。体内研究显示,Micro-CT,组织学分析和ELISA检测显示Chrysosplenetin可防止OVX小鼠中的雌激素缺乏诱导的骨丢失。

总之,该研究表明,Chrysosplenetin通过调节Wnt/β-catenin通路改善hBMSCs的成骨细胞生成和雌激素缺乏诱导的骨丢失的成骨。

原始出处:

Hong G, He X, et al., Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone loss. Stem Cell Res Ther. 2019 Aug 29;10(1):277. doi: 10.1186/s13287-019-1375-x.

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    2020-04-05 canlab
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    2020-05-19 维他命
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1794709, encodeId=db591e9470987, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Feb 25 18:15:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734163, encodeId=bb571e3416319, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Sun Apr 05 04:15:00 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961683, encodeId=e8591961683a5, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue May 19 08:15:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947631, encodeId=252f194e63161, content=<a href='/topic/show?id=a62d468e65' target=_blank style='color:#2F92EE;'>#chrysosplenetin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4687, encryptionId=a62d468e65, topicName=chrysosplenetin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1dfd2500156, createdName=12498c24m69暂无昵称, createdTime=Wed Nov 13 21:15:00 CST 2019, time=2019-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743580, encodeId=e7b91e4358008, content=<a href='/topic/show?id=c3df1015e54d' target=_blank style='color:#2F92EE;'>#骨丧失#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101575, encryptionId=c3df1015e54d, topicName=骨丧失)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a0f35143673, createdName=mei543, createdTime=Sat May 30 20:15:00 CST 2020, time=2020-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871398, encodeId=38cb18e139872, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 14 10:15:00 CST 2019, time=2019-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1482268, encodeId=9d3814822680a, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Sun Sep 01 10:15:00 CST 2019, time=2019-09-01, status=1, ipAttribution=)]
    2020-05-30 mei543
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1794709, encodeId=db591e9470987, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Feb 25 18:15:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734163, encodeId=bb571e3416319, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Sun Apr 05 04:15:00 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961683, encodeId=e8591961683a5, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue May 19 08:15:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947631, encodeId=252f194e63161, content=<a href='/topic/show?id=a62d468e65' target=_blank style='color:#2F92EE;'>#chrysosplenetin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4687, encryptionId=a62d468e65, topicName=chrysosplenetin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1dfd2500156, createdName=12498c24m69暂无昵称, createdTime=Wed Nov 13 21:15:00 CST 2019, time=2019-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743580, encodeId=e7b91e4358008, content=<a href='/topic/show?id=c3df1015e54d' target=_blank style='color:#2F92EE;'>#骨丧失#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101575, encryptionId=c3df1015e54d, topicName=骨丧失)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a0f35143673, createdName=mei543, createdTime=Sat May 30 20:15:00 CST 2020, time=2020-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871398, encodeId=38cb18e139872, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 14 10:15:00 CST 2019, time=2019-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1482268, encodeId=9d3814822680a, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Sun Sep 01 10:15:00 CST 2019, time=2019-09-01, status=1, ipAttribution=)]
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