Baidu
map

Lancet子刊:50万人数据揭示日常补充维生素D对急性呼吸道感染的预防作用

2021-04-03 Nebula MedSci原创

日常补充维生素D可预防急性呼吸道感染吗?

2017年,一项对25个关于补充维生素D(VitD)预防急性呼吸道感染(ARI)的随机对照试验(RCT)的荟萃分析显示,该干预具有保护作用。本研究旨在在最新的荟萃分析中检查补充VitD与预防ARI的相关性

研究人员检索了MEDLINE、Embase、对照试验的Cochrane中央注册系统、Web of Science和ClinicalTrials.gov注册中心数据库2020年5月1日前的双盲研究,纳入对比补充VitD3、VitD2或25[OH]D对比安慰剂或低剂量VitD对照试验。

总体上,共筛查了1528篇文章,其中46项RCT(共75541位受试者)复合要求。在43项研究49419位受试者中有48488位(98.1%)的主要预后数据可及。

各试验中罹患一种或多种ARI的患者比例

在补充VitD组,患有一种或多种ARI的患者比例明显低于安慰剂组(61.3%[14332/23364] vs 62.3%[14217/22802];优势比[OR] 0.92,p=0.018)。无论补充多少浓度的25(OH)D对罹患一种或多种ARI的风险均无显著影响。

但是,在每日予以补充VitD的试验中,展示出了对ARI的预防作用(OR 0.78,19项研究,p=0.03):日补充剂量 400-1000IU(0.70, p=0.16)、持续补充不超过12个月(0.82,p=0.021)、入组年龄在1-16岁(0.71,p=0.90)。

随机安慰剂为对照的试验的次要预后

补充VitD组与安慰剂组和剂量、频率、研究持续时间或年龄之间无显著相互作用。此外,补充VitD组与安慰剂组的不良事件发生情况也无明显差别。

总而言之,虽然各试验之间存在明显的异质性,但仍能证明与安慰剂相比,补充VitD是安全的,且可降低ARI的总体风险,虽然降低幅度不大

原始出处:

David A Jolliffe, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. The Lancet Diabetes &Endocrinology. March 30, 2021

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1831095, encodeId=546d1831095b4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 20 07:17:58 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282556, encodeId=005b1282556c3, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551675, encodeId=20cc15516e5c5, content=<a href='/topic/show?id=645352243ae' target=_blank style='color:#2F92EE;'>#急性呼吸道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52243, encryptionId=645352243ae, topicName=急性呼吸道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682614208898, createdName=fangcong, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034247, encodeId=6ef0103424e07, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Apr 03 19:17:58 CST 2021, time=2021-04-03, status=1, ipAttribution=)]
    2021-09-20 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1831095, encodeId=546d1831095b4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 20 07:17:58 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282556, encodeId=005b1282556c3, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551675, encodeId=20cc15516e5c5, content=<a href='/topic/show?id=645352243ae' target=_blank style='color:#2F92EE;'>#急性呼吸道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52243, encryptionId=645352243ae, topicName=急性呼吸道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682614208898, createdName=fangcong, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034247, encodeId=6ef0103424e07, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Apr 03 19:17:58 CST 2021, time=2021-04-03, status=1, ipAttribution=)]
    2021-04-05 zhmscau
  3. [GetPortalCommentsPageByObjectIdResponse(id=1831095, encodeId=546d1831095b4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 20 07:17:58 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282556, encodeId=005b1282556c3, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551675, encodeId=20cc15516e5c5, content=<a href='/topic/show?id=645352243ae' target=_blank style='color:#2F92EE;'>#急性呼吸道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52243, encryptionId=645352243ae, topicName=急性呼吸道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682614208898, createdName=fangcong, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034247, encodeId=6ef0103424e07, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Apr 03 19:17:58 CST 2021, time=2021-04-03, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1831095, encodeId=546d1831095b4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 20 07:17:58 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282556, encodeId=005b1282556c3, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551675, encodeId=20cc15516e5c5, content=<a href='/topic/show?id=645352243ae' target=_blank style='color:#2F92EE;'>#急性呼吸道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52243, encryptionId=645352243ae, topicName=急性呼吸道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682614208898, createdName=fangcong, createdTime=Mon Apr 05 07:17:58 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034247, encodeId=6ef0103424e07, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Apr 03 19:17:58 CST 2021, time=2021-04-03, status=1, ipAttribution=)]
    2021-04-03 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

相关资讯

JCEM:补充维生素D可预防癌症吗?

对于糖尿病前期和超重/肥胖症的人群,补充维生素D对发生癌症或结肠息肉的风险没有显著影响。

Clin Nutr: 每月补充维生素D对憩室疾病住院时间的影响

憩室病是最常见的胃肠道患者住院的病因之一,在过去的十年中,年轻人的憩室疾病住院的发生率显著增加了,学界目前有一种假设:地理和季节性变化导致了低维生素D状况的变化。

JAMA Network Open:高剂量的维生素D或可预防COVID-19,尤其是对黑人

维生素D是维持生命所必需的一种脂溶性维生素,具有多种生理作用,包括对钙调节、骨密度和免疫功能的影响。维生素D缺乏,通常定义为25-羟基维生素D低于20ng /mL,而将足够的维生素D定义为30ng /

 Clinical Nutrition: 25(OH)D的生物利用度与弥漫性大B细胞淋巴瘤患者的临床结局相关

弥漫性大B细胞淋巴瘤(DLBCL)是最具侵入性的疾病的非霍奇金淋巴瘤(NHL)的亚型之一,占NHL患者的30-40%。

Neurology:耳石症频发,多补补维生素D和钙试试!

良性阵发性位置性眩晕(BPPV)的特点是由头部相对于重力的位置变化引起的短暂眩晕发作,也叫耳石症。虽然BPPV是一种良性疾病,但近86%的BPPV患者因眩晕、呕吐等症状严重影响了其日常生活、工作和学习

Plos Med:预防1型糖尿病,补充维生素D并不靠谱!

缺乏维生素D并不是1型糖尿病的主要诱因

Baidu
map
Baidu
map
Baidu
map