Nature Biotechnology：微软和剑桥科学家联手开发白血病发生电脑模型

2015-02-17 佚名生物谷

一直以来，科学家们都希望从根源上认识白血病的致病机理。最近来自微软公司和剑桥大学的研究人员们构建了一个电脑模型用于模拟血细胞的整个发育过程。这也使模拟白血病相关基因在血细胞发育过程中是如何表达并最终导致白血病发生成为了可能。这一方法为今后的研究人员更好认识白血病以及其他血液疾病的致病机理提供了一个更便捷的工具。在最近一期的Nature Biotechnology中，微软和剑桥大学的科学家介绍他

一直以来，科学家们都希望从根源上认识白血病的致病机理。最近来自微软公司和剑桥大学的研究人员们构建了一个电脑模型用于模拟血细胞的整个发育过程。这也使模拟白血病相关基因在血细胞发育过程中是如何表达并最终导致白血病发生成为了可能。这一方法为今后的研究人员更好认识白血病以及其他血液疾病的致病机理提供了一个更便捷的工具。

在最近一期的Nature Biotechnology中，微软和剑桥大学的科学家介绍他们首先测定了3900个造血干细胞的基因活性，并将获得的数据进行综合构建出了一个模型。科学家声称利用这个模型，研究人员能够进行一些简单、快速的模拟实验，而在实验室中这些实验一般耗时长达数周之久。例如在关于Hox和Sox两种基因在白血病发生中所扮演的角色上，这种新型的模型预测结果与实验结果就达到了良好的一致性。

研究人员希望今后这种模型能够用于更多疾病的研究上。

原始出处

Moignard V1, Woodhouse S1, Haghverdi L2, Lilly AJ3, Tanaka Y4, Wilkinson AC1, Buettner F5, Macaulay IC6, Jawaid W7, Diamanti E1, Nishikawa SI8, Piterman N9, Kouskoff V3, Theis FJ2, Fisher J10, Göttgens B1.Decoding the regulatory network of early blood development from single-cell gene expression measurements.Nat Biotechnol. 2015 Feb 9.

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2015-07-15 cathymary

#Biotech#

103 0
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2015-03-29 huperzia

#白血病发生#

96 0
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2015-12-18 shock_melon

#TEC#

87 0
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2015-06-30 fzwish20000

#Technology#

74 0
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2015-05-26 huirong

#微软#

117 0
[GetPortalCommentsPageByObjectIdResponse(id=1927620, encodeId=029d192e6205e, content=<a href='/topic/show?id=a59234e3b4' target=_blank style='color:#2F92EE;'>#Biotech#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3473, encryptionId=a59234e3b4, topicName=Biotech)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Wed Jul 15 23:11:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1717432, encodeId=037b1e174325f, content=<a href='/topic/show?id=6089e177842' target=_blank style='color:#2F92EE;'>#白血病发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71778, encryptionId=6089e177842, topicName=白血病发生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=961832410013, createdName=huperzia, createdTime=Sun Mar 29 19:11:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652126, encodeId=a35d165212699, content=<a href='/topic/show?id=13d01e24509' target=_blank style='color:#2F92EE;'>#TEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17245, encryptionId=13d01e24509, topicName=TEC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852f24292001, createdName=shock_melon, createdTime=Fri Dec 18 13:11:00 CST 2015, time=2015-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795578, encodeId=c5e91e95578e9, content=<a href='/topic/show?id=87881e249e8' target=_blank style='color:#2F92EE;'>#Technology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17249, encryptionId=87881e249e8, topicName=Technology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Tue Jun 30 22:11:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722267, encodeId=c4a91e22267bc, content=<a href='/topic/show?id=234b5081072' target=_blank style='color:#2F92EE;'>#微软#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50810, encryptionId=234b5081072, topicName=微软)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=754533248452, createdName=huirong, createdTime=Tue May 26 00:11:00 CST 2015, time=2015-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917131, encodeId=2321191e131c4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Jun 21 03:11:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880513, encodeId=d12c188051365, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Aug 28 17:11:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16294, encodeId=0fab162943f, content=太过基础了, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 13:04:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
2015-06-21 sunylz

#Bio#

56 0
[GetPortalCommentsPageByObjectIdResponse(id=1927620, encodeId=029d192e6205e, content=<a href='/topic/show?id=a59234e3b4' target=_blank style='color:#2F92EE;'>#Biotech#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3473, encryptionId=a59234e3b4, topicName=Biotech)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Wed Jul 15 23:11:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1717432, encodeId=037b1e174325f, content=<a href='/topic/show?id=6089e177842' target=_blank style='color:#2F92EE;'>#白血病发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71778, encryptionId=6089e177842, topicName=白血病发生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=961832410013, createdName=huperzia, createdTime=Sun Mar 29 19:11:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652126, encodeId=a35d165212699, content=<a href='/topic/show?id=13d01e24509' target=_blank style='color:#2F92EE;'>#TEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17245, encryptionId=13d01e24509, topicName=TEC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852f24292001, createdName=shock_melon, createdTime=Fri Dec 18 13:11:00 CST 2015, time=2015-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795578, encodeId=c5e91e95578e9, content=<a href='/topic/show?id=87881e249e8' target=_blank style='color:#2F92EE;'>#Technology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17249, encryptionId=87881e249e8, topicName=Technology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Tue Jun 30 22:11:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722267, encodeId=c4a91e22267bc, content=<a href='/topic/show?id=234b5081072' target=_blank style='color:#2F92EE;'>#微软#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50810, encryptionId=234b5081072, topicName=微软)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=754533248452, createdName=huirong, createdTime=Tue May 26 00:11:00 CST 2015, time=2015-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917131, encodeId=2321191e131c4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Jun 21 03:11:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880513, encodeId=d12c188051365, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Aug 28 17:11:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16294, encodeId=0fab162943f, content=太过基础了, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 13:04:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
2015-08-28 liye789132251

#Nat#

73 0
[GetPortalCommentsPageByObjectIdResponse(id=1927620, encodeId=029d192e6205e, content=<a href='/topic/show?id=a59234e3b4' target=_blank style='color:#2F92EE;'>#Biotech#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3473, encryptionId=a59234e3b4, topicName=Biotech)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Wed Jul 15 23:11:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1717432, encodeId=037b1e174325f, content=<a href='/topic/show?id=6089e177842' target=_blank style='color:#2F92EE;'>#白血病发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71778, encryptionId=6089e177842, topicName=白血病发生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=961832410013, createdName=huperzia, createdTime=Sun Mar 29 19:11:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652126, encodeId=a35d165212699, content=<a href='/topic/show?id=13d01e24509' target=_blank style='color:#2F92EE;'>#TEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17245, encryptionId=13d01e24509, topicName=TEC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852f24292001, createdName=shock_melon, createdTime=Fri Dec 18 13:11:00 CST 2015, time=2015-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795578, encodeId=c5e91e95578e9, content=<a href='/topic/show?id=87881e249e8' target=_blank style='color:#2F92EE;'>#Technology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17249, encryptionId=87881e249e8, topicName=Technology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Tue Jun 30 22:11:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722267, encodeId=c4a91e22267bc, content=<a href='/topic/show?id=234b5081072' target=_blank style='color:#2F92EE;'>#微软#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50810, encryptionId=234b5081072, topicName=微软)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=754533248452, createdName=huirong, createdTime=Tue May 26 00:11:00 CST 2015, time=2015-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917131, encodeId=2321191e131c4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Jun 21 03:11:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880513, encodeId=d12c188051365, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Aug 28 17:11:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16294, encodeId=0fab162943f, content=太过基础了, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 13:04:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
2015-02-17 49.4.167.**

太过基础了

148 0

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