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J Allergy Clin Immunol:天然花粉接触下过敏和不过敏受试者症状预测生物标记的确定

2020-04-22 AlexYang MedSci原创

在敏感个体中,花粉接触能够诱导局部和系统过敏免疫响应,但是非敏感个体也接触花粉。花粉接触下的症状表达动力学还未有系统研究,尤其是在非过敏个体中。

在敏感个体中,花粉接触能够诱导局部和系统过敏免疫响应,但是非敏感个体也接触花粉。花粉接触下的症状表达动力学还未有系统研究,尤其是在非过敏个体中。

最近,有研究人员在天然花粉接触下监测了体液免疫反应,目的是揭示潜在的季节性症状严重程度的鼻生物标志物,并确定了保护性因素。研究发现,季节过敏性鼻炎(SAR)受试者症状随着花粉浓度的变化而变化,并依据花粉类型在0-13天存在时间差。7名非过敏的受试者中,4名表现出了季节性症状,而另外3名没有出现。不具有过敏的累积症状要比具有SAR的更低,但与花粉接触具有相似的动力学特征。另外,鼻eotaxin-2、CCL22/MDC和单核细胞趋化蛋白-1水平在SAR受试者中更高,而IL-8水平在没有过敏症个体中更高。主成分分析和Spearman相关性分析鉴定了IL-8、IL-33、slgG4和lgE抗体鼻水平可以预测季节鼻症状严重度。

最后,研究人员指出,鼻花粉特异性lgA和lgG亚型在体液腔室内具有潜在的保护作用。不考虑特异反应性,鼻IL-8、IL-33、slgG4和lgE水平可以作为花粉特异性症状表达的预测生物标记。

原始出处:

Gökkaya M, Damialis A, Nussbaumer T et al. Defining biomarkers to predict symptoms in subjects with and without allergy under natural pollen exposure. J Allergy Clin Immunol. 06 April 2020.

 

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