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Mol Pharm:查尔酮衍生物的体外成骨分化和抗菌潜力

2018-08-05 MedSci MedSci原创

既往研究探究了查尔酮衍生物作为抗癌剂,抗氧化剂和抗炎剂的治疗作用。在这项研究中,我们合成了四种不同类型的查尔酮衍生物,并体外证明了其生物活性。 我们根据芳环上相似的取代基将这些衍生物分为两组查耳酮,测试了细胞活力和增殖潜能,表明A环上的甲氧基取代基可以增强细胞毒性和抗增殖潜力,这取决于查尔酮浓度。此外,我们还通过ALP染色研究了C2C12细胞的成骨分化,ALP染色是成骨的早期标志物,这表明查

既往研究探究了查尔酮衍生物作为抗癌剂,抗氧化剂和抗炎剂的治疗作用。在这项研究中,我们合成了四种不同类型的查尔酮衍生物,并体外证明了其生物活性。

我们根据芳环上相似的取代基将这些衍生物分为两组查耳酮,测试了细胞活力和增殖潜能,表明A环上的甲氧基取代基可以增强细胞毒性和抗增殖潜力,这取决于查尔酮浓度。此外,我们还通过ALP染色研究了C2C12细胞的成骨分化,ALP染色是成骨的早期标志物,这表明查尔酮不仅可以诱导BMP-2的活性,还可以抑制BMP拮抗剂noggin的活性。此外,在A环的2-,4-和6-位带有羟基的查耳酮抑制了变形链球菌的生长。

综上所述,该研究结果表明,本研究所合成的查尔酮衍生物可以是促进骨分化的治疗剂,有望在牙科中抑制变形链球菌的增殖。

原始出处:

Choi D, Park JC, et al., In Vitro Osteogenic Differentiation and Antibacterial Potentials of Chalcone Derivatives. Mol Pharm. 2018 Jul 24. doi: 10.1021/acs.molpharmaceut.8b00288.

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    2019-01-26 HinsMax
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    2019-02-08 jj000001
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