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Pharmazie:抗痛风药用植物的详细审查

2015-03-22 MedSci MedSci原创

摘要目的:该评论文章的目的是概述当前使用的和那些高承诺的抗痛风的植物。方法:从数据库中检索所有截止2013年3月25日的相关文献。检索关键词“痛风”、“痛风性关节炎”、“高尿酸血症”、“尿酸”、“黄嘌呤氧化酶(XO )抑制剂”、“促尿酸尿”、“尿酸盐转运蛋白1 ( URAT1 ) ”和“葡萄糖转运9 ( GLUT9 ) ”。草本关键词包括“中草药”、“药用植物”、“天然产品”、“植物药”和“植物疗

目的:
该评论文章的目的是综述当前使用的和那些有较高潜在希望的抗痛风的植物。

方法:
从数据库中检索所有截止2013年3月25日的相关文献。检索关键词“痛风”、“痛风性关节炎”、“高尿酸血症”、“尿酸”、“黄嘌呤氧化酶(XO )抑制剂”、“促尿酸尿”、“尿酸盐转运蛋白1 ( URAT1 ) ”和“葡萄糖转运9 ( GLUT9 ) ”。草本关键词包括“中草药”、“药用植物”、“天然产品”、“植物药”和“植物疗法” 。抗炎作用的关键词包括 “抗炎效应”、 “白介素-6(IL- 6) ”、“白介素-8(IL- 8 )”、“白细胞介素-1β (IL -1β )”和“α肿瘤坏死因子”。

结果:
尿酸的代谢和抗炎作用是黄嘌呤氧化酶(XO )抑制剂的主要作用。来自植物的众多提取物有抗痛风潜力。在体外研究中,显示黄酮、生物碱、精油、酚类化合物、单宁酸、环烯醚萜苷和香豆素通过黄嘌呤氧化酶(XO )抑制作用达到抗痛风效应,而木脂素,三萜类和叶黄素是通过它们的抗炎作用。在动物研究中,显示精油、木脂素与单宁对减少尿酸生成和利尿具有双向调节作用。揭示生物碱可抑制尿酸生成,并且具有抗炎作用,或者是两者共同协调组合作用。酚类化合物和黄酮类化合物抑制尿酸生成,并发现利尿也可促进抗炎作用。在极少数人的研究中发现,从秋水仙中提取的活性成分——秋水仙碱具有抗炎作用,而对于其他植物的提取物研究,显示同样存在具有抗痛风的潜力,但需要进一步的植物化学成分调查以确定其主要作用的活性成分。此外,这些具有抗氧化活性的植物对痛风的管理非常有效,因此需要进行进一步的更细致的研究。目前的审查是对具有治疗痛风的药用植物的潜在性的详细讨论。

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    2018-11-26 kafei

    学习了谢谢

    0

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    2015-08-15 jj000001
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    2015-04-13 吴颖

    很好的文章,学习了

    0

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    2015-04-09 180.154.193.**

    秋水仙碱副作用太大了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=353684, encodeId=6c9d353684cd, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Nov 26 09:18:25 CST 2018, time=2018-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787167, encodeId=dc421e8716748, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sat Aug 15 10:37:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745174, encodeId=16e91e451747d, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Jul 21 04:37:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908185, encodeId=da8d1908185ba, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Tue Jul 21 14:37:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1714716, encodeId=cd6c1e147163d, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Tue Feb 09 16:37:00 CST 2016, time=2016-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21098, encodeId=4f9321098c7, content=很好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3r6Ir8EADbw8kut6NgpfYKrksLd7rsf9GSZGCUZkpHosu8Jsibzk64KSuO8dFfOW7J5kW4bjib4eI/0, createdBy=d0201619051, createdName=吴颖, createdTime=Mon Apr 13 08:08:00 CST 2015, time=2015-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20025, encodeId=9f352002552, content=秋水仙碱副作用太大了, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=180.154.193.**, createdTime=Thu Apr 09 20:13:00 CST 2015, time=2015-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19934, encodeId=5dde199348b, content=植物药属于中药吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3r6Ir8EADbw8kut6NgpfYKrksLd7rsf9GSZGCUZkpHosu8Jsibzk64KSuO8dFfOW7J5kW4bjib4eI/0, createdBy=d0201619051, createdName=吴颖, createdTime=Wed Apr 08 09:20:00 CST 2015, time=2015-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19177, encodeId=26df191e781, content=从秋水仙中提取的活性成分——秋水仙碱具有抗炎作用,而对于其他植物的提取物研究,显示同样存在具有抗痛风的潜力,但需要进, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:20:00 CST 2015, time=2015-03-31, status=1, ipAttribution=)]
    2015-04-08 吴颖

    植物药属于中药吧

    0

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    2015-03-31 x35042875

    从秋水仙中提取的活性成分——秋水仙碱具有抗炎作用,而对于其他植物的提取物研究,显示同样存在具有抗痛风的潜力,但需要进

    0

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