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Am J Reprod Immunol：滋养层中miR-210水平升高或是先兆子痫发病的原因

2017-11-06 MedSci MedSci原创

miR-210先兆子痫
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先兆子痫是以妊娠高血压和蛋白尿为特征的严重妊娠期疾病。miR-210在先兆子痫患者的胎盘中显著过表达。通过电穿孔将hsa-miR-210-3p寡核苷酸转染孕早期人类滋养层细胞系Swan71细胞。使用芯片技术分析改变的转录组。将差异表达基因（DEGs）聚成基因本体注释生物学过程。通过核糖核蛋白免疫沉淀评估miR-210和IGFBP3mRNA之间物理相互作用的程度。微阵列分析显示，Swan 71细胞中

先兆子痫是以妊娠高血压和蛋白尿为特征的严重妊娠期疾病。miR-210在先兆子痫患者的胎盘中显著过表达。

通过电穿孔将hsa-miR-210-3p寡核苷酸转染孕早期人类滋养层细胞系Swan71细胞。使用芯片技术分析改变的转录组。将差异表达基因（DEGs）聚成基因本体注释生物学过程。通过核糖核蛋白免疫沉淀评估miR-210和IGFBP3mRNA之间物理相互作用的程度。

微阵列分析显示，Swan 71细胞中miR-210的水平升高了408DEGs。这些基因在涉及先兆子痫发病机理的几个生物过程。IGFBP3是一种与先兆子痫病理生理相关的基因，被确认为miR-210的靶基因。

我们已经证明，人类滋养层中miR-210水平升高改变了已知先兆子痫相关基因的表达谱，并成为先兆子痫进展所必需的多种生物学过程的基因靶点。

原始出处：

Ahn S, Jeong E, Min JW, et al., Identification of genes dysregulated by elevation of microRNA-210 levels in human trophoblasts cell line, Swan 71. Am J Reprod Immunol. 2017 Nov;78(5). doi: 10.1111/aji.12722. Epub 2017 Jun 27.

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    2018-10-21 smallant2002

    #miR#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1930538, encodeId=ec01193053882, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Oct 21 00:42:00 CST 2018, time=2018-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070760, encodeId=999820e076061, content=<a href='/topic/show?id=aa6466541c7' target=_blank style='color:#2F92EE;'>#滋养层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66541, encryptionId=aa6466541c7, topicName=滋养层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac1c235, createdName=tonychen21, createdTime=Sun Sep 16 06:42:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703051, encodeId=115b1e030516d, content=<a href='/topic/show?id=1b871185e3a' target=_blank style='color:#2F92EE;'>#miR-21#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11857, encryptionId=1b871185e3a, topicName=miR-21)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8bc730475489, createdName=dongjia2020, createdTime=Fri Dec 01 03:42:00 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601939, encodeId=9a2a1601939ce, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Wed Nov 08 11:42:00 CST 2017, time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259272, encodeId=92562592e269, content=滋养层中mi****0水平升高或是先兆子痫发病的原因, beContent=null, objectType=article, channel=null, level=null, likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Nov 06 23:28:31 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
    2018-09-16 tonychen21

    #滋养层#

    0

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    2017-12-01 dongjia2020

    #miR-21#

    0

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    2017-11-08 sunylz

    #PRO#

    0

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    2017-11-06 有备才能无患

    滋养层中mi****0水平升高或是先兆子痫发病的原因

    0

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