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Radiology：CT纹理指标能对肝癌晚期患者生存期提示点什么？

2018-04-25 shaosai MedSci原创

肝癌CT索拉菲尼
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本研究旨在验证是否增强CT图像纹理特点能够有助于预测治疗的肝癌晚期患者的整体生存期（OS）和进展时间（TTP），并将结果发表在Radiology上。

本研究旨在验证是否增强CT图像纹理特点能够有助于预测治疗的肝癌晚期患者的整体生存期（OS）和进展时间（TTP），并将结果发表在Radiology上。

本研究共纳入了92例行索拉菲尼治疗的晚期HCC患者。64/92例患者（70%）（女性6例，中位数年龄为66岁）为训练组，28例患者(30%)（女性5例，中位数年龄为66岁）为验证组。在治疗前动脉晚期和门静脉期HCC图像进行CT纹理分析。从体素分布图总提取平均灰度强度、熵、峰度、偏度和标准差。采用4分法对病变异质性进行分级。利用Spearman等级相关评价视觉分析与纹理分析的相关性。单变量Kaplan-Meier和多变量Cox比例危害回归分析来评价训练组OS和TTP的独立预测指标。利用Kaplan-Meier在验证组验证指标的预测能力。

结果为，肿瘤一致性的视觉分析与动脉期(P = .012)和门静脉期的熵(P = .038)具有相关性。门静脉期熵在优良差等级的纹理上可作为OS的独立预测指标，并在验证组得到验证(P < .05)。在验证组患者熵值有差异时中位数生存期分别为＜272天和＞741天。动脉期得到的纹理参数(P > .085)和视觉分析(P > .11)与生存期间无显着相关性。

本研究表明，治疗前门静脉期肿瘤熵可作为评价索拉菲尼治疗HCC晚期患者的生存期。

原始出处：


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    2018-12-01 爆笑小医

    #患者生存#

    0

  2. 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    2018-04-28 131****1460

    学习了受益匪浅

    0

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    2018-04-26 仁者大医

    #生存期#

    0

  4. 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    2018-04-26 三生有幸9135

    -`学习一下谢谢分享`

    0

  5. 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    2018-04-26 changjiu

    学习一下谢谢

    0

  6. 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    2018-04-25 明月清辉

    谢谢分享.学习了

    0

  7. 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    2018-04-25 wzb521zf

    一起学习学习

    0

  8. 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    2018-04-25 131****1460

    学习了受益匪浅

    0

  9. 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    2018-04-25 yjs木玉

    好好好好好好好好

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content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Apr 25 06:47:53 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309010, encodeId=a3a23090106f, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Apr 25 05:54:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), 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    2018-04-25 changjiu

    学习一下谢谢

    0

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