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Lancet Gastroen Hepatol:全球胰腺癌疾病负担研究——1990-2017

2019-10-22 MedSci MedSci原创

研究发现,从1990年到2017年,在全球范围内,胰腺癌导致的死亡、病例和DALYs的数量增加了一倍以上。随着人口老龄化,胰腺癌的发病率可能会继续上升。预防战略应侧重于可改变的风险因素防控

在全世界范围内,胰腺癌的发病率和死亡率都在增加。评估胰腺癌的负担及其全球、区域和国家模式对于制定和更好地分配资源以控制胰腺癌风险因素、制定早期检测方法以及提供更快速和更有效的治疗至关重要。

研究考察了胰腺癌死亡率、发病率和残疾调整寿命(DALYs),并估计胰腺癌危险因素导致的死亡比例:吸烟、高空腹血糖和高体重指数。

2017年,全球共发生胰腺癌448000例,其中男性232000例(51.9%)。1990年,胰腺癌的年龄标准化发病率为每100000人年5.0,2017年增至每100000人年5.7。死亡人数增加了2.3倍,从1990年的196000人增加到2017年的441000人。胰腺癌导致的DALYs增加了2.1倍,从1990年的440万增加到2017年的910万。在2017年,最高的年龄标准化死亡率出现在格陵兰(每10万人年17.4)和乌拉圭(每10万人年12.1),这些国家在1990年也有最高的年龄标准死亡率,而孟加拉国(每10万人年1.9)2017年死亡率最低。1990年,圣多美和普林西比(每10万人-年1.3)的发病率最低。男性在65-69岁和女性在75-79岁时发病和死亡人数达到高峰。2017年,全球年龄标准化胰腺癌死亡主要归因于吸烟(21.1%)、高空腹血糖(8.9%)和高体重指数(6.2%)。

研究发现,从1990年到2017年,在全球范围内,胰腺癌导致的死亡、病例和DALYs的数量增加了一倍以上。随着人口老龄化,胰腺癌的发病率可能会继续上升。预防战略应侧重于可改变的风险因素防控。

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    2020-06-07 许安
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    2020-02-08 howi
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    2019-10-24 gwc384

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