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EASD 2014:我国1型糖尿病患者自身抗体阳性率调查结果公布

2014-09-28 伊文 中华医学会糖尿病学分会

中山大学附属第三医院翁建平教授等在EASD 2014年会上公布了我国1型糖尿病患者自身抗体阳性率调查结果:我国成人1型糖尿病患者的自身抗体阳性率低于1型糖尿病高发国家。抗体阳性患者的临床进展更为迅速,与糖尿病自身抗体导致β细胞功能下降更快有关。(摘要号287) 研究数据来自于广东省1型糖尿病转化医学研究,本次分析共纳入1070例1型糖尿病患者,患者平均年龄为31.7岁,平均糖尿病病程为4

中山大学附属第三医院翁建平教授等在EASD 2014年会上公布了我国1型糖尿病患者自身抗体阳性率调查结果:我国成人1型糖尿病患者的自身抗体阳性率低于1型糖尿病高发国家。抗体阳性患者的临床进展更为迅速,与糖尿病自身抗体导致β细胞功能下降更快有关。(摘要号287)

研究数据来自于广东省1型糖尿病转化医学研究,本次分析共纳入1070例1型糖尿病患者,患者平均年龄为31.7岁,平均糖尿病病程为4.14年。结果显示,51.2%的患者至少有1个自身抗体阳性,另4.4%的患者GADA、IA-2A和ZnT8A等3个自身抗体全阳性。仅GADA、IA-2A和ZnT8A抗体阳性对应的患者比例分别为89.3%、10.2%和0.5%。糖尿病自身抗体阳性患者较抗体阴性患者初诊年龄小(中位数25.8岁 vs.27.2岁)、女性偏多、诊断时BMI较低(中位数18.34 vs.19.49 kg/m2)、空腹(中位数0.12 vs.0.17 ng/ml)及餐后2小时C肽水平偏低(中位数0.13 vs.0.22 ng/ml)、HbA1c水平(中位数8.8% vs.8.4%)更高。抗体阳性数目与糖尿病病程呈正相关(rs=0.064,P=0.04),与空腹C肽水平呈负相关(rs=-0.149,P=0.00)。随着病程延长,糖尿病自身抗体阳性组的空腹C肽下降速率快于阴性组。


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    2015-06-05 ljjj1053

    好好学习学习

    0

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    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

  4. 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href='/topic/show?id=e3a39203226' target=_blank style='color:#2F92EE;'>#调查结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92032, encryptionId=e3a39203226, topicName=调查结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=904e12916305, createdName=zll0629, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

  5. 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href='/topic/show?id=e3a39203226' target=_blank style='color:#2F92EE;'>#调查结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92032, encryptionId=e3a39203226, topicName=调查结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=904e12916305, createdName=zll0629, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
    2015-04-11 okhuali
  6. 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href='/topic/show?id=e3a39203226' target=_blank style='color:#2F92EE;'>#调查结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92032, encryptionId=e3a39203226, topicName=调查结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=904e12916305, createdName=zll0629, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=26095, encodeId=2976260958c, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=201, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Fri Jun 05 16:30:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004356, encodeId=c5952004356e8, content=<a href='/topic/show?id=54ebe8621cf' target=_blank style='color:#2F92EE;'>#结果公布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78621, encryptionId=54ebe8621cf, topicName=结果公布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Sat Apr 04 09:20:00 CST 2015, time=2015-04-04, status=1, ipAttribution=), 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createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Wed Feb 11 22:20:00 CST 2015, time=2015-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968177, encodeId=aaa619681e7e1, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Feb 15 23:20:00 CST 2015, time=2015-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473830, encodeId=893914e3830f1, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534084, encodeId=e1c5153408411, content=<a href='/topic/show?id=576e643634' target=_blank style='color:#2F92EE;'>#EASD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6436, encryptionId=576e643634, topicName=EASD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21f812527653, createdName=qilu_qi, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537862, encodeId=ccc2153e862e9, content=<a href='/topic/show?id=e3a39203226' target=_blank style='color:#2F92EE;'>#调查结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92032, encryptionId=e3a39203226, topicName=调查结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=904e12916305, createdName=zll0629, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=26095, encodeId=2976260958c, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=201, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Fri Jun 05 16:30:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004356, encodeId=c5952004356e8, content=<a href='/topic/show?id=54ebe8621cf' target=_blank style='color:#2F92EE;'>#结果公布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78621, encryptionId=54ebe8621cf, topicName=结果公布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Sat Apr 04 09:20:00 CST 2015, time=2015-04-04, status=1, ipAttribution=), 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690590, encodeId=b1e916905907f, content=<a href='/topic/show?id=5c472843a1' target=_blank style='color:#2F92EE;'>#ASD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2843, encryptionId=5c472843a1, topicName=ASD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e8529069357, createdName=okhuali, createdTime=Sat Apr 11 17:20:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948094, encodeId=64631948094e9, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Wed Feb 11 22:20:00 CST 2015, time=2015-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968177, encodeId=aaa619681e7e1, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Feb 15 23:20:00 CST 2015, time=2015-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473830, encodeId=893914e3830f1, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534084, encodeId=e1c5153408411, content=<a href='/topic/show?id=576e643634' target=_blank style='color:#2F92EE;'>#EASD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6436, encryptionId=576e643634, topicName=EASD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21f812527653, createdName=qilu_qi, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537862, encodeId=ccc2153e862e9, content=<a href='/topic/show?id=e3a39203226' target=_blank style='color:#2F92EE;'>#调查结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92032, encryptionId=e3a39203226, topicName=调查结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=904e12916305, createdName=zll0629, createdTime=Tue Sep 30 00:20:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
    2014-09-30 qilu_qi
  10. 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