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ANN RHEUM DIS: 18F-FDG-PET/CT在鉴定原因不明发热(FUO)和原因不明炎症(IUO)病因中的作用

2017-09-20 xiangting MedSci原创

18F-氟脱氧葡萄糖正电子发射断层扫描有助于一半以上的FUO和IUO病例确定正确的诊断。

原因不明发热(FUO)和原因不明炎症(IUO)在诊断时具有挑战性。潜在疾病的诊断可能通过18F-氟脱氧葡萄糖正电子发射断层扫描(18F-FDG-PET)得到改善。

这是一项前瞻性研究,测试了18F-FDG-PET/CT在大型FUO或IUO患者队列中的诊断效用,并定义增加18F-FDG-PET/CT 诊断可能性的参数。FUO或IUO患者除了进行标准的诊断处理外还接受18F-FDG-PET/CT扫描。18F-FDG-PET/CT结果被分为对建立最终诊断有帮助或无帮助。使用二元logistic回归识别与诊断性18F-FDG-PET/CT 相关的临床参数。

共240例患者入组,72例为FUO,142例为IUO,26例此前患FUO或IUO(exFUO / IUO)。190例患者明确了诊断(79.2%)。FUO组最主要的诊断为成人发作型Still病(15.3%),IUO组为大血管血管炎(21.1%)和风湿性多肌痛(18.3%)exFUO/IUO组为IgG4相关性疾病(15.4%)。在136例患者中(所有患者的56.7%,明确诊断患者的71.6%),18F-FDG-PET/CT是阳性的有助于诊断。诊断性18F-FDG-PET/CT的预测标志物是年龄超过50岁(p = 0.019),C反应蛋白(CRP)水平超过30mg/L(p = 0.002)和无发热(p = 0.001)。

18F-FDG-PET/CT扫描有助于一半以上的FUO和IUO病例确定正确的诊断。没有间歇发热、年龄较大和CRP水平升高增加诊断性18F-FDG-PET/CT 的可能性。

原始出处:

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    2017-09-30 xugumin
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    2018-05-12 kcb069
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    2017-12-03 feather89
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  7. [GetPortalCommentsPageByObjectIdResponse(id=2024600, encodeId=cdab2024600d9, content=<a href='/topic/show?id=5dc715e04b' target=_blank style='color:#2F92EE;'>#8F-FDG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1570, encryptionId=5dc715e04b, topicName=8F-FDG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sat Sep 30 07:27:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785996, encodeId=70761e8599636, content=<a href='/topic/show?id=3c58e33112' target=_blank style='color:#2F92EE;'>#FDG-PET/CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7331, encryptionId=3c58e33112, topicName=FDG-PET/CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat May 12 21:27:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738161, encodeId=08e11e38161fc, content=<a href='/topic/show?id=42a8204242b' target=_blank style='color:#2F92EE;'>#不明炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20424, encryptionId=42a8204242b, topicName=不明炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832134362003, createdName=124986d2m20暂无昵称, createdTime=Sat Jan 27 01:27:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012408, encodeId=56e7201240855, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Sep 30 03:27:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726756, encodeId=2a191e2675624, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Dec 03 11:27:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309670, encodeId=33d713096e0d1, content=<a href='/topic/show?id=412114080d1' target=_blank style='color:#2F92EE;'>#PET/CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14080, encryptionId=412114080d1, topicName=PET/CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Sep 22 06:27:00 CST 2017, time=2017-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331070, encodeId=6e7b13310e0f3, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Fri Sep 22 06:27:00 CST 2017, time=2017-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246022, encodeId=2cfc2460220b, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/07/5fd7f6b597acf767e8c3c43ef0485c3f.jpg, createdBy=a1252104908, createdName=金戈铁马, createdTime=Wed Sep 20 15:40:30 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2024600, encodeId=cdab2024600d9, content=<a href='/topic/show?id=5dc715e04b' target=_blank style='color:#2F92EE;'>#8F-FDG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1570, encryptionId=5dc715e04b, topicName=8F-FDG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sat Sep 30 07:27:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785996, encodeId=70761e8599636, content=<a href='/topic/show?id=3c58e33112' target=_blank style='color:#2F92EE;'>#FDG-PET/CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7331, encryptionId=3c58e33112, topicName=FDG-PET/CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat May 12 21:27:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738161, encodeId=08e11e38161fc, content=<a href='/topic/show?id=42a8204242b' target=_blank style='color:#2F92EE;'>#不明炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20424, encryptionId=42a8204242b, topicName=不明炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832134362003, createdName=124986d2m20暂无昵称, createdTime=Sat Jan 27 01:27:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012408, encodeId=56e7201240855, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Sep 30 03:27:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726756, encodeId=2a191e2675624, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Dec 03 11:27:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309670, encodeId=33d713096e0d1, content=<a href='/topic/show?id=412114080d1' target=_blank style='color:#2F92EE;'>#PET/CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14080, encryptionId=412114080d1, topicName=PET/CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Sep 22 06:27:00 CST 2017, time=2017-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331070, encodeId=6e7b13310e0f3, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Fri Sep 22 06:27:00 CST 2017, time=2017-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246022, encodeId=2cfc2460220b, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/07/5fd7f6b597acf767e8c3c43ef0485c3f.jpg, createdBy=a1252104908, createdName=金戈铁马, createdTime=Wed Sep 20 15:40:30 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 金戈铁马

    不错

    0

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