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Sci Rep:王汉中团队发现人博卡病毒可抑制NF-κB信号通路

2017-04-27 佚名 武汉病毒研究所

人博卡病毒(HBoV)是在2005年新发现的一种能够引起婴幼儿肠道和呼吸道感染疾病的病原体。作为一种新发病毒病原,其致病机制和病毒如何逃逸宿主天然免疫识别的分子机制等重要科学问题亟待阐明。天然免疫系统是人体防止病原体入侵的第一道屏障,NF-κB信号通路是天然免疫系统的重要组成部分。近期,中国科学院武汉病毒研究所王汉中研究团队在博卡病毒调控NF-κB信号通路机制方面取得重要进展,揭示了博卡病毒NS1

人博卡病毒(HBoV)是在2005年新发现的一种能够引起婴幼儿肠道和呼吸道感染疾病的病原体。作为一种新发病毒病原,其致病机制和病毒如何逃逸宿主天然免疫识别的分子机制等重要科学问题亟待阐明。天然免疫系统是人体防止病原体入侵的第一道屏障,NF-κB信号通路是天然免疫系统的重要组成部分。近期,中国科学院武汉病毒研究所王汉中研究团队在博卡病毒调控NF-κB信号通路机制方面取得重要进展,揭示了博卡病毒NS1蛋白通过与转录因子p65NTD区域结合抑制p65结合到κB结合位点,从而抑制下游基因转录的机制。该论文已在线发表在《科学报告》(Scientific Reports)上。

由于NF-κB信号通路在抵御病毒入侵方面的重要作用,许多病毒都进化出抑制NF-κB信号通路的机制。大多数病毒抑制NF-κB信号通路的靶点都位于细胞质内的IKK复合体上,已知的能够在细胞核中抑制NF-κB信号通路的病毒非常少。王汉中研究团队通过研究发现,博卡病毒的NS1蛋白能够与p65相互作用,进一步发现NS1能够与p65NTD区域结合,NTD区域是p65识别κB结合位点的关键结构域。通过DNA结合实验,该团队发现NS1能够抑制p65结合到κB结合位点上。因此,推测博卡病毒NS1蛋白通过结合到p65 NTD区域,从而抑制p65与κB结合位点的相互作用,进而抑制下游基因的转录。

该研究第一次报道了博卡病毒具有调控NF-κB信号通路的作用,为理解博卡病毒的致病性提供了重要依据。论文的第一作者为博士生刘庆世。

该研究得到了国家自然科学基金的支持。

原始出处:

Qingshi Liu, Zhenfeng Zhang, Zhenhua Zheng,et al.Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65.Scientific Reports 6, Article number: 28481

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    2018-04-30 祝您健康

    有没有临床推广

    0

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    2017-04-28 天涯183

    非常好的文章,学习了,很收益

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=310776, encodeId=ff7a310e7675, content=有没有临床推广, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Mon Apr 30 21:58:54 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946225, encodeId=96ac194622504, content=<a href='/topic/show?id=001e12e38b2' target=_blank style='color:#2F92EE;'>#NF-κB信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12738, encryptionId=001e12e38b2, topicName=NF-κB信号通路)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu May 04 13:26:00 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539600, encodeId=27a3153960043, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Apr 29 08:26:00 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191291, encodeId=7c3b191291f8, content=非常好的文章,学习了,很收益, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Apr 28 01:01:19 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191276, encodeId=97771912e6c9, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Fri Apr 28 00:34:43 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191202, encodeId=6848191202d3, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJicFGXtYqfjGiaibNdjOiaRgkexnXiciaDeXaLiaKicovcicDugdYwRPSnQj3FlfXBwVLB5ANB9PGFyB0kraQ/0, createdBy=35b01663265, createdName=1ddf3e1dm99(暂无匿称), createdTime=Thu Apr 27 21:42:43 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191181, encodeId=db67191181a0, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Apr 27 18:21:25 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-04-28 tanxingdoctor

    学习了谢谢分享

    0

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    2017-04-27 1ddf3e1dm99(暂无匿称)

    学习了谢谢

    0

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    2017-04-27 komasun

    学习了谢谢分享

    0

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