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Cell Metab:胰岛细胞酶蛋白Bace2成糖尿病治疗新药靶

2012-02-25 MedSci MedSci原创

近来,发表在Cell Metabolism杂志上一个研究表明:酶蛋白Bace2调控β细胞的生长,基于抑制Bace2开发出来的化合物能显著刺激β细胞的生长。 该研究团队早期已经发现位于细胞膜表面名叫TMEM27的蛋白质能够增加小鼠体内胰岛聚集。如果敲除掉Tmen27后,该蛋白质完全的失活。如果我们在不敲除Tmen27的情况下,同时增加Tmen27蛋白水平,结果有利于促进β细胞的生长。 研究人

近来,发表在Cell Metabolism杂志上一个研究表明:酶蛋白Bace2调控β细胞的生长,基于抑制Bace2开发出来的化合物能显著刺激β细胞的生长。

该研究团队早期已经发现位于细胞膜表面名叫TMEM27的蛋白质能够增加小鼠体内胰岛聚集。如果敲除掉Tmen27后,该蛋白质完全的失活。如果我们在不敲除Tmen27的情况下,同时增加Tmen27蛋白水平,结果有利于促进β细胞的生长。

研究人员通过筛选各种剪切性的TMEN27分子,发现酶蛋白Bace2也像Tmen27一样锚定在胰岛β细胞的表面。工作人员用缺失Bace2的小鼠研究发现,与正常小鼠相比,缺失Bace2的小鼠胰岛的体积更大,胰岛中胰岛细胞数量也增多了,能更好地清除血液中多余的葡萄糖。

工作人员还发现了一种有效的化合物能抑制β细胞表面Bace2,以此来增加β细胞的生长。当研究人员用化合物喂养老鼠后,老鼠体内Bace2蛋白表达明显下降,β细胞的生长呈现上升趋势。相信不久针对抑制β细胞表面Bace2,促进β细胞生长新的治疗糖尿病的药物会在不久研发成功。

doi:10.1016/j.cmet.2011.06.018
Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass

Daria Esterházy, Ina Stützer, Haiyan Wang, Markus P. Rechsteiner, Jeremy Beauchamp, Heinz D?beli, Hans Hilpert, Hugues Matile, Michael Prummer, Alexander Schmidt, Nora Lieske, Bernhard Boehm, Lorella Marselli, Domenico Bosco, Julie Kerr-Conte, Ruedi Aebersold, Giatgen Andreia Spinas, Holger Moch, Cristiano Migliorini, Markus Stoffel

Decreased β cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human β cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented β cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of β cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic β cell mass.

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    2013-02-08 维他命
  4. [GetPortalCommentsPageByObjectIdResponse(id=1989903, encodeId=f4da198990380, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Dec 11 17:02:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868462, encodeId=2df51868462d7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 29 14:02:00 CST 2012, time=2012-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958675, encodeId=d2d919586e5f6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Feb 08 07:02:00 CST 2013, time=2013-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887312, encodeId=d5c9188e31254, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon Apr 23 21:02:00 CST 2012, time=2012-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655642, encodeId=177a1655642e5, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Mar 14 22:02:00 CST 2012, time=2012-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895615, encodeId=2cba1895615a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 13 16:02:00 CST 2012, time=2012-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749325, encodeId=f22e1e49325c2, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Mar 25 20:02:00 CST 2012, time=2012-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694218, encodeId=22fc169421896, content=<a href='/topic/show?id=be7483919ec' target=_blank style='color:#2F92EE;'>#胰岛细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83919, encryptionId=be7483919ec, topicName=胰岛细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6d29584648, createdName=vividelife, createdTime=Fri Mar 30 14:02:00 CST 2012, time=2012-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382985, encodeId=4c8d1382985f7, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sun Feb 26 15:02:00 CST 2012, time=2012-02-26, status=1, ipAttribution=)]
    2012-04-23 guojianrong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1989903, encodeId=f4da198990380, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Dec 11 17:02:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868462, encodeId=2df51868462d7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 29 14:02:00 CST 2012, time=2012-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958675, encodeId=d2d919586e5f6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Feb 08 07:02:00 CST 2013, time=2013-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887312, encodeId=d5c9188e31254, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon Apr 23 21:02:00 CST 2012, time=2012-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655642, encodeId=177a1655642e5, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Mar 14 22:02:00 CST 2012, time=2012-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895615, encodeId=2cba1895615a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 13 16:02:00 CST 2012, time=2012-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749325, encodeId=f22e1e49325c2, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Mar 25 20:02:00 CST 2012, time=2012-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694218, encodeId=22fc169421896, content=<a href='/topic/show?id=be7483919ec' target=_blank style='color:#2F92EE;'>#胰岛细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83919, encryptionId=be7483919ec, topicName=胰岛细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6d29584648, createdName=vividelife, createdTime=Fri Mar 30 14:02:00 CST 2012, time=2012-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382985, encodeId=4c8d1382985f7, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sun Feb 26 15:02:00 CST 2012, time=2012-02-26, status=1, ipAttribution=)]
    2012-03-14 shanyongle
  6. [GetPortalCommentsPageByObjectIdResponse(id=1989903, encodeId=f4da198990380, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Dec 11 17:02:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868462, encodeId=2df51868462d7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 29 14:02:00 CST 2012, time=2012-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958675, encodeId=d2d919586e5f6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Feb 08 07:02:00 CST 2013, time=2013-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887312, encodeId=d5c9188e31254, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon Apr 23 21:02:00 CST 2012, time=2012-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655642, encodeId=177a1655642e5, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Mar 14 22:02:00 CST 2012, time=2012-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895615, encodeId=2cba1895615a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 13 16:02:00 CST 2012, time=2012-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749325, encodeId=f22e1e49325c2, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Mar 25 20:02:00 CST 2012, time=2012-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694218, encodeId=22fc169421896, content=<a href='/topic/show?id=be7483919ec' target=_blank style='color:#2F92EE;'>#胰岛细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83919, encryptionId=be7483919ec, topicName=胰岛细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6d29584648, createdName=vividelife, createdTime=Fri Mar 30 14:02:00 CST 2012, time=2012-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382985, encodeId=4c8d1382985f7, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sun Feb 26 15:02:00 CST 2012, time=2012-02-26, status=1, ipAttribution=)]
    2012-05-13 一闲
  7. [GetPortalCommentsPageByObjectIdResponse(id=1989903, encodeId=f4da198990380, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Dec 11 17:02:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868462, encodeId=2df51868462d7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 29 14:02:00 CST 2012, time=2012-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958675, encodeId=d2d919586e5f6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Feb 08 07:02:00 CST 2013, time=2013-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887312, encodeId=d5c9188e31254, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon Apr 23 21:02:00 CST 2012, time=2012-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655642, encodeId=177a1655642e5, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Mar 14 22:02:00 CST 2012, time=2012-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895615, encodeId=2cba1895615a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 13 16:02:00 CST 2012, time=2012-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749325, encodeId=f22e1e49325c2, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Mar 25 20:02:00 CST 2012, time=2012-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694218, encodeId=22fc169421896, content=<a href='/topic/show?id=be7483919ec' target=_blank style='color:#2F92EE;'>#胰岛细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83919, encryptionId=be7483919ec, topicName=胰岛细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6d29584648, createdName=vividelife, createdTime=Fri Mar 30 14:02:00 CST 2012, time=2012-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382985, encodeId=4c8d1382985f7, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sun Feb 26 15:02:00 CST 2012, time=2012-02-26, status=1, ipAttribution=)]
    2012-03-25 baoya
  8. [GetPortalCommentsPageByObjectIdResponse(id=1989903, encodeId=f4da198990380, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Dec 11 17:02:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868462, encodeId=2df51868462d7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 29 14:02:00 CST 2012, time=2012-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958675, encodeId=d2d919586e5f6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Feb 08 07:02:00 CST 2013, time=2013-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887312, encodeId=d5c9188e31254, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon Apr 23 21:02:00 CST 2012, time=2012-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655642, encodeId=177a1655642e5, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Mar 14 22:02:00 CST 2012, time=2012-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895615, encodeId=2cba1895615a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 13 16:02:00 CST 2012, time=2012-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749325, encodeId=f22e1e49325c2, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Mar 25 20:02:00 CST 2012, time=2012-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694218, encodeId=22fc169421896, content=<a href='/topic/show?id=be7483919ec' target=_blank style='color:#2F92EE;'>#胰岛细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83919, encryptionId=be7483919ec, topicName=胰岛细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6d29584648, createdName=vividelife, createdTime=Fri Mar 30 14:02:00 CST 2012, time=2012-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382985, encodeId=4c8d1382985f7, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sun Feb 26 15:02:00 CST 2012, time=2012-02-26, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1989903, encodeId=f4da198990380, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Dec 11 17:02:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868462, encodeId=2df51868462d7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Dec 29 14:02:00 CST 2012, time=2012-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958675, encodeId=d2d919586e5f6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Feb 08 07:02:00 CST 2013, time=2013-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887312, encodeId=d5c9188e31254, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon Apr 23 21:02:00 CST 2012, time=2012-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655642, encodeId=177a1655642e5, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Mar 14 22:02:00 CST 2012, time=2012-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895615, encodeId=2cba1895615a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 13 16:02:00 CST 2012, time=2012-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749325, encodeId=f22e1e49325c2, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Mar 25 20:02:00 CST 2012, time=2012-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694218, encodeId=22fc169421896, content=<a href='/topic/show?id=be7483919ec' target=_blank style='color:#2F92EE;'>#胰岛细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83919, encryptionId=be7483919ec, topicName=胰岛细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6d29584648, createdName=vividelife, createdTime=Fri Mar 30 14:02:00 CST 2012, time=2012-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382985, encodeId=4c8d1382985f7, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sun Feb 26 15:02:00 CST 2012, time=2012-02-26, status=1, ipAttribution=)]
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