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Stroke:机械血栓切除术后二十四小时再闭塞的相关因素与长期预后

2019-08-06 xing.T MedSci原创

由此可见,成功MT后24小时内再闭塞与他汀类药物预处理、闭塞部位、更复杂的手术操作、动脉粥样硬化病因以及再通后残留的血栓或狭窄独立相关。再闭塞对长期结局的影响凸显了监测和预防这种早期并发症的必要性。

早期动脉再通是急性缺血性卒中预后的重要决定因素。然而,在最初再通后可能会发生再闭塞。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估了机械血栓切除术(MT)后再闭塞的相关因素和长期预后。

从前瞻性构建的急性卒中登记和洛桑队列分析中,研究人员纳入了连续就诊的前后循环卒中患者,这些患者接受了成功的MT(脑梗塞改良治疗2b-3)和24小时血管成像治疗。在该时间点重新闭塞被定义为在MT结束后再通的动脉段内新发颅内闭塞。通过多变量Logisitc回归,研究人员调查了相关因素和3个月结局。在4:1匹配队列中,研究人员还评估了残余血栓或狭窄对再通后血管造影图像作为再闭塞潜在预测因子的作用。

在473例成功再通的患者中,该研究纳入了423例(89%)。其中,28例(6.6%)发生24小时再闭塞。入院前他汀类药物治疗(aOR [校正比值比]为0.27; 95%CI为0.08-0.94)、颅内颈内动脉闭塞(aOR为3.53; 95%CI为1.50-8.32)、通过次数(aOR为1.31; 95%CI为1.06-1.62)、MT期间的瞬时再闭塞(aOR为8.55; 95%CI为2.14-34.09)和动脉粥样硬化病因(aOR为3.14; 95%CI为1.34-7.37)与再闭塞独立相关。在匹配队列分析中,残余血栓或狭窄与再闭塞相关(aOR为15.6; 95%CI为4.6-52.8)。经历再次闭塞的患者的预后较差(aOR为5.0; 95%CI为1.2-20.0)。

由此可见,成功MT后24小时内再闭塞与他汀类药物预处理、闭塞部位、更复杂的手术操作、动脉粥样硬化病因以及再通后残留的血栓或狭窄独立相关。再闭塞对长期结局的影响凸显了监测和预防这种早期并发症的必要性。 

原始出处:

João Pedro Marto.et al.Twenty-Four–Hour Reocclusion After Successful Mechanical Thrombectomy Associated Factors and Long-Term Prognosis.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.026228

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在症状发作的第一个6小时内,临床医生可应用高级影像学技术指导可行机械血栓切除术(MT)治疗的缺血性卒中患者的选择。但越来越多的研究证据表明,高级神经影像学技术是非常有价值且与非时间依赖性的预后因素。

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