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Diabetes Care:1型糖尿病成年人大麻的使用与糖尿病酮症酸中毒风险增加有关

2019-10-19 xing.T MedSci原创

由此可见,1型糖尿病成年人使用大麻与DKA风险增加相关。提供者应告知其患者使用大麻可能引起DKA的潜在风险。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估1型糖尿病患者中大麻使用者与非使用者发生糖尿病性酮症酸中毒(DKA)的频率。

研究人员使用对潜在混杂因素进行校正的Logistic回归模型评估了1型糖尿病成年人通过大麻总物质得分(TSC)衡量的大麻使用量与之后12月期间DKA发生之间的相关性。

在932例1型糖尿病成年人中,61例患者TSC>4,将其归为中度大麻使用者。调整性别、研究访问的年龄和HbA1c后,使用大麻会使1型糖尿病成年人的DKA风险增加两倍(比值比为2.5 [95%CI为1.0-5.9])。

由此可见,1型糖尿病成年人使用大麻与DKA风险增加相关。提供者应告知其患者使用大麻可能引起DKA的潜在风险。 

原始出处:


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  5. 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  6. 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createdName=mashirong, createdTime=Mon Oct 21 09:44:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346126, encodeId=093313461264e, content=<a href='/topic/show?id=ecbb9553661' target=_blank style='color:#2F92EE;'>#酮症酸中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95536, encryptionId=ecbb9553661, topicName=酮症酸中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 09:44:00 CST 2019, time=2019-10-21, status=1, ipAttribution=)]
    2019-10-21 kcb069
  8. 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  9. 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    2019-10-21 mashirong
  10. 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由此可见,对于1型糖尿病成年人,血糖控制似乎比先前估计的要差。随着HbA1c的增加,所有并发症的发生率均增加。与HbA1c<7%相比,HbA1c≥9%分别与SH和DKA的发病率高出2倍和12倍有关。与较年长的成年人相比,较年轻的成年人血糖控制不佳相关的SH和DKA风险更高。

BMJ Open:“新计算器”助力临床医师精准诊断糖尿病分型

精准确诊患者的糖尿病分型在糖尿病诊疗中举足轻重,是临床工作中的难点之一。由于患者临床特征的复杂性,尽管胰岛细胞相关的抗体检测、1型糖尿病遗传风险在一定程度上有助于诊断,却并不能做到精准诊断。 近期发表于BMJ OPEN杂志的一项研究显示一种在线使用的“新计算器”有助于快速诊断不同类型的糖尿病。

NEJM:替利珠单抗与1型糖尿病风险

由此可见,替利珠单抗可延迟高风险参与者进展为临床1型糖尿病。

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