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Am Heart J：稳定性冠心病双重抗血小板治疗进展

2014-06-26 高晓方 译 医学论坛网

稳定性冠心病双重抗血小板治疗进展
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法国一项研究表明，在当前临床实践中相当一部分稳定性冠脉疾病患者接受双重抗血小板治疗(DAPT)。研究者表示，虽然未观察到出血风险增加，但也不支持延长DAPT时间。论文于6月23日在线发表于《美国心脏杂志》(Am Heart J)。 此项研究从一项稳定性冠脉疾病前瞻性登记中纳入3691例患者，并依据进入系统时抗血小板治疗方案将受试者分为DAPT组和单一抗血小板治疗(SAPT)组。主要转归由心血管死

法国一项研究表明，在当前临床实践中相当一部分稳定性冠脉疾病患者接受双重抗血小板治疗(DAPT)。研究者表示，虽然未观察到出血风险增加，但也不支持延长DAPT时间。论文于6月23日在线发表于《美国心脏杂志》(Am Heart J)。

此项研究从一项稳定性冠脉疾病前瞻性登记中纳入3691例患者，并依据进入系统时抗血小板治疗方案将受试者分为DAPT组和单一抗血小板治疗(SAPT)组。主要转归由心血管死亡、心肌梗死或卒中组成。

结果显示，共有868例(24%)患者接受DAPT。与DAPT应用呈正相关性的因素包括入组时持续性心绞痛、体重指数、1至3年心肌梗死、1至3年心肌血运重建、多血管冠状动脉疾病、既往药物洗脱支架置入以及既往主动脉或外周血管介入;呈负相关的因素包括年龄、既往冠脉搭桥和左室射血分数。

2年时SAPT和DAPT组患者的主要转归发生率相似(4.6%对5.5%)，出血发生率亦相似。

原始出处：

Gilles Lemesle, MDemail address, Nicolas Lamblin, MD, PhD, Thibaud Meurice, MD, Olivier Tricot, MD, Robert Lallemant, MD, Olivier Nugue, MD, Maxence Delomez, MD, Octave Equine, MD, Sylvie Tondeux, MD, Christophe Bauters, MD.Dual antiplatelet therapy in patients with stable coronary artery disease in modern practice: Prevalence, correlates and impact on prognosis (from the CORONOR study).Am Heart J.June 23 2014. 

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    2014-12-07 jiangfeng5067

    #稳定性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1900423, encodeId=f48a1900423d1, content=<a href='/topic/show?id=0983e529745' target=_blank style='color:#2F92EE;'>#稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75297, encryptionId=0983e529745, topicName=稳定性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Sun Dec 07 12:10:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355875, encodeId=449113558e5b3, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jun 28 00:10:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402157, encodeId=2fcf140215e06, content=<a href='/topic/show?id=26163e63362' target=_blank style='color:#2F92EE;'>#双重抗血小板治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37633, encryptionId=26163e63362, topicName=双重抗血小板治疗)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTL6ka7cRR8xsokbAYjhg0mZeBm79vHeyXiaMibkYndHaibgmfg1JDA0AXlGaY8Og4IiaREUFYuBwekPoQ/132, createdBy=19852392148, createdName=bioon4, createdTime=Sat Jun 28 00:10:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562248, encodeId=ed3b15622480e, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Jun 28 00:10:00 CST 2014, time=2014-06-28, status=1, ipAttribution=)]
    2014-06-28 zhaojie88

    #ART#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1900423, encodeId=f48a1900423d1, content=<a href='/topic/show?id=0983e529745' target=_blank style='color:#2F92EE;'>#稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75297, encryptionId=0983e529745, topicName=稳定性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Sun Dec 07 12:10:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355875, encodeId=449113558e5b3, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jun 28 00:10:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402157, encodeId=2fcf140215e06, content=<a href='/topic/show?id=26163e63362' target=_blank style='color:#2F92EE;'>#双重抗血小板治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37633, encryptionId=26163e63362, topicName=双重抗血小板治疗)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTL6ka7cRR8xsokbAYjhg0mZeBm79vHeyXiaMibkYndHaibgmfg1JDA0AXlGaY8Og4IiaREUFYuBwekPoQ/132, createdBy=19852392148, createdName=bioon4, createdTime=Sat Jun 28 00:10:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562248, encodeId=ed3b15622480e, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Jun 28 00:10:00 CST 2014, time=2014-06-28, status=1, ipAttribution=)]
    2014-06-28 bioon4

    #双重抗血小板治疗#

    0

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    2014-06-28 爆笑小医

    #HEART#

    0

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