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Brit J Cancer:IGF-1R与前列腺癌根治性放射治疗后的不良结果有关

2017-10-11 AlexYang MedSci原创

激活类型1类胰岛素生长因子受体(IGF-1Rs)经历内化和核转移可以促进细胞生存。之前,研究人员报道了IGF-1R抑制剂推迟了损伤修复,并且可以使前列腺癌细胞对电离辐射敏感。最近,他们又探究了这些发现的临床相关性。研究人员通过免疫组化技术评估了IGF-1R和临床治疗结果的相关性,样本为136名男性的诊断性活检样本,并且这些男性因前列腺癌接受了55-70Gy体外放射治疗;研究人员还在外科治疗病人中的

激活类型1类胰岛素生长因子受体(IGF-1Rs)经历内化和核转移可以促进细胞生存。之前,研究人员报道了IGF-1R抑制剂推迟了损伤修复,并且可以使前列腺癌细胞对电离辐射敏感。最近,他们又探究了这些发现的临床相关性。研究人员通过免疫组化技术评估了IGF-1R和临床治疗结果的相关性,样本为136名男性的诊断性活检样本,并且这些男性因前列腺癌接受了55-70Gy体外放射治疗;研究人员还在外科治疗病人中的发现与公布的转录数据进行了比较。

研究发现,放射治疗后,总复发自由生存时间在那些肿瘤中包含高水平总细胞质和核质IGF-1R的病人中更短。高水平总IGF-1R与高初始格林森等级和转移风险,具有生化复发的细胞质和核质IGF-1R相关,包括了那些在放射治疗后经历局部复发的病人,这也表明了对放射治疗具有抗性。在多变量分析中,细胞质、核质和总IGF-1R与总复发独立相关,并且细胞质IGF-1R是放射治疗后生化复发的独立预测因子。类胰岛素生长因子受体的表达在根治性前列腺切除术后,与生化复发没有关系。最后,研究人员指出,在那些患有前列腺癌且包含有高水平总IGF-1R或者高水平细胞质IGF-1R的病人中,这些数据阐释了术后放射治疗复发风险具有增加的结果。

原始出处:

Tamara Aleksic, Clare Verrill, Richard J Bryant et al. IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer. Brit J Cancer. 03 Oct 2017.

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    2018-02-27 qingrejiedu
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    2018-06-19 xxxx1049
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    2017-10-13 131****2916

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    0

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    2017-10-13 jeanqiuqiu
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    2017-10-12 三生有幸9135

    学习一下谢谢分享

    0

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