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Clin Oral Investig：釉质基质衍生物对膜龈术后伤口愈合的作用

2020-07-31 MedSci原创 MedSci原创

釉质基质衍生物膜龈手术
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釉质基质衍生物(EMD)对退缩覆盖手术后伤口愈合的潜在影响在文献中仍有争议。因此，本项随机、对照、单盲临床研究旨在从临床和免疫学角度探讨EMD对改良冠状上进隧道技术（MCAT）和上皮下结缔组织移植（s

釉质基质衍生物(EMD)对退缩覆盖手术后伤口愈合的潜在影响在文献中仍有争议。因此，本项随机、对照、单盲临床研究旨在从临床和免疫学角度探讨EMD对改良冠状上进隧道技术（MCAT）和上皮下结缔组织移植（sCTG）治疗单发和多发牙龈退缩术后早期伤口愈合和临床效果的潜在影响。

 

共有40例全身健康的Miller I、II或III级单发或多发牙龈退缩的患者接受MCAT+sCTG治疗，伴有或不伴有EMD。患者随机分配到试验或对照治疗。在基线、术后2天和1周测定炎症标志物（白细胞介素（IL）-1β、IL-8、IL-10和基质金属蛋白酶（MMP）-8）。基线和术后6个月时进行评估凹陷深度(RD)、凹陷宽度(RW)、角化组织宽度(KT)和探诊深度(PD)。通过视觉模拟量表对患者报告的结果进行分析。

 

结果显示，在早期伤口愈合过程中，两组在炎症标志物和患者报告的结果方面没有发现显著的统计学差异。在试验组中，RD从基线时的4.0±1.2mm降低到6个月时的0.9±1.3mm（P <0.001），而对照组的相应数值分别为基线时的4.5±2.0mm和6个月时的1.0±1.0mm。6个月时，试验组和对照组的平均根覆盖率分别为78±26%和77±18%。

 

总之，在其范围内，目前的数据未能显示出EMD对使用MCAT和sCTG进行衰退覆盖手术后伤口愈合相关的临床和免疫学参数的影响。

 

原始出处：

 

Alexandra Stähli, Jean-Claude Imber,et al., Effect of enamel matrix derivative on wound healing following gingival recession coverage using the modified coronally advanced tunnel and subepithelial connective tissue graft: a randomised, controlled, clinical study. Clin Oral Investig. 2020 Feb;24(2):1043-1051. doi: 10.1007/s00784-019-03008-6.

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    2020-11-17 小几洁

    #Oral#

    0

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    2020-08-10 仁心济世

    #衍生物#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2020643, encodeId=574d2020643b0, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Nov 17 02:01:17 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812683, encodeId=ac9418126831f, content=<a href='/topic/show?id=d193900940b' target=_blank style='color:#2F92EE;'>#衍生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90094, encryptionId=d193900940b, topicName=衍生物)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 17:01:17 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757213, encodeId=53ad1e5721363, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Sat Jan 02 21:01:17 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051591, encodeId=868b205159143, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Jul 14 16:01:17 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309908, encodeId=1187130990882, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Aug 02 11:01:17 CST 2020, time=2020-08-02, status=1, ipAttribution=)]
    2021-01-02 ms7899726347904398

    #基质#

    0

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    2021-07-14 xiangyuzhou971

    #EST#

    0

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    2020-08-02 chenzhuanggui

    #伤口愈合#

    0

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