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Front Bioeng :PRP和PRF与血栓血运重建对未成熟恒牙的治疗效果

2018-11-02 MedSci MedSci原创

本综述旨在比较富血小板血浆(PRP)和富血小板纤维蛋白(PRF)与血栓血运重建(BCR)对未成熟恒牙再生的临床疗效。回顾12篇文献确定了222例未成熟恒牙,这些恒牙经过PRP,PRF或BCR再生治疗,进行了至少一年的随访。对1年后222个未成熟恒牙进行的荟萃分析进行比较,以评估PRP,PRF和BCR完成根尖闭合,根尖周病变愈合反应,牙根延长和牙本质壁增厚的能力。结果显示,1年后根尖闭合或复位的平均

本综述旨在比较富血小板血浆(PRP)和富血小板纤维蛋白(PRF)与血栓血运重建(BCR)对未成熟恒牙再生的临床疗效。

回顾12篇文献确定了222例未成熟恒牙,这些恒牙经过PRP,PRF或BCR再生治疗,进行了至少一年的随访。对1年后222个未成熟恒牙进行的荟萃分析进行比较,以评估PRP,PRF和BCR完成根尖闭合,根尖周病变愈合反应,牙根延长和牙本质壁增厚的能力。

结果显示,1年后根尖闭合或复位的平均成功率为:PRP(85.1%)PRF(85.2%)和BCR(58.8%)。 1年后根部延长的平均成功率为:BCR(64.1%),PRP(64.2%)和PRF(74.1%)。BCR的根尖周病变愈合反应为88.9%,PRP为100%,PRF为100%。BCR的牙本质壁增厚为100%,PRP为100%,PRF为100%。PRP和PRF后顶端闭合发生率高于BCR(Fischer试验,P <0.0011),PRP,PRF和BCR治疗同样有效(Fischer试验,P> 0.05)。

总之,6-28岁的儿童和年轻人的骨折或龋坏的未成熟恒牙其牙冠可恢复,但是可以通过使用血管干细胞血液干细胞吸入消毒的根管空间的血运重建术来再生薄的牙本质壁。尽管BCR是最常见的血运重建方法,但如果使用PRF和PRP代替BCR来进行未成熟恒牙的再生,则可能更频繁地发生根尖闭合。正确使用再生程序可以成功地消除来自未成熟恒牙根尖周区域的细菌,这有助于治愈局部病变,并且避免除了再生组织以加强未成熟牙齿结构外的复杂的根尖手术,有助于防止牙齿骨折和牙齿脱落。

原始出处:

Peter E. Murray. Platelet-Rich Plasma and Platelet-Rich Fibrin Can Induce Apical Closure More Frequently Than Blood-Clot Revascularization for the Regeneration of Immature Permanent Teeth: A Meta-Analysis of Clinical Efficacy. Front Bioeng Biotechnol. 2018; 6: 139.

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    2019-05-01 spoonycyy
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    2019-06-12 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1958333, encodeId=51851958333e9, content=<a href='/topic/show?id=3f5514e764a' target=_blank style='color:#2F92EE;'>#PRP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14776, encryptionId=3f5514e764a, topicName=PRP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Fri Mar 01 21:07:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894082, encodeId=c1b118940824b, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64637, encryptionId=5e456463eee, topicName=治疗效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Feb 10 00:07:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081501, encodeId=d498208150125, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed May 01 02:07:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918373, encodeId=ff8f19183e32f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 12 14:07:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581333, encodeId=6c691581333ce, content=<a href='/topic/show?id=f8341466954' target=_blank style='color:#2F92EE;'>#PRF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14669, encryptionId=f8341466954, topicName=PRF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a6716763517, createdName=12498b3em13(暂无昵称), createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601260, encodeId=31f81601260ac, content=<a href='/topic/show?id=eb1b5282260' target=_blank style='color:#2F92EE;'>#恒牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52822, encryptionId=eb1b5282260, topicName=恒牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27f418863982, createdName=zhaozuguo, createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031964, encodeId=534410319640b, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046662, encodeId=b9ed1046662e8, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1958333, encodeId=51851958333e9, content=<a href='/topic/show?id=3f5514e764a' target=_blank style='color:#2F92EE;'>#PRP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14776, encryptionId=3f5514e764a, topicName=PRP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Fri Mar 01 21:07:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894082, encodeId=c1b118940824b, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64637, encryptionId=5e456463eee, topicName=治疗效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Feb 10 00:07:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081501, encodeId=d498208150125, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed May 01 02:07:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918373, encodeId=ff8f19183e32f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 12 14:07:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581333, encodeId=6c691581333ce, content=<a href='/topic/show?id=f8341466954' target=_blank style='color:#2F92EE;'>#PRF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14669, encryptionId=f8341466954, topicName=PRF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a6716763517, createdName=12498b3em13(暂无昵称), createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601260, encodeId=31f81601260ac, content=<a href='/topic/show?id=eb1b5282260' target=_blank style='color:#2F92EE;'>#恒牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52822, encryptionId=eb1b5282260, topicName=恒牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27f418863982, createdName=zhaozuguo, createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031964, encodeId=534410319640b, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046662, encodeId=b9ed1046662e8, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
    2018-11-04 zhaozuguo
  7. [GetPortalCommentsPageByObjectIdResponse(id=1958333, encodeId=51851958333e9, content=<a href='/topic/show?id=3f5514e764a' target=_blank style='color:#2F92EE;'>#PRP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14776, encryptionId=3f5514e764a, topicName=PRP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Fri Mar 01 21:07:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894082, encodeId=c1b118940824b, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64637, encryptionId=5e456463eee, topicName=治疗效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Feb 10 00:07:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081501, encodeId=d498208150125, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed May 01 02:07:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918373, encodeId=ff8f19183e32f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 12 14:07:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581333, encodeId=6c691581333ce, content=<a href='/topic/show?id=f8341466954' target=_blank style='color:#2F92EE;'>#PRF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14669, encryptionId=f8341466954, topicName=PRF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a6716763517, createdName=12498b3em13(暂无昵称), createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601260, encodeId=31f81601260ac, content=<a href='/topic/show?id=eb1b5282260' target=_blank style='color:#2F92EE;'>#恒牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52822, encryptionId=eb1b5282260, topicName=恒牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27f418863982, createdName=zhaozuguo, createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031964, encodeId=534410319640b, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046662, encodeId=b9ed1046662e8, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
    2018-11-02 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1958333, encodeId=51851958333e9, content=<a href='/topic/show?id=3f5514e764a' target=_blank style='color:#2F92EE;'>#PRP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14776, encryptionId=3f5514e764a, topicName=PRP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Fri Mar 01 21:07:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894082, encodeId=c1b118940824b, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64637, encryptionId=5e456463eee, topicName=治疗效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Feb 10 00:07:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081501, encodeId=d498208150125, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed May 01 02:07:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918373, encodeId=ff8f19183e32f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 12 14:07:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581333, encodeId=6c691581333ce, content=<a href='/topic/show?id=f8341466954' target=_blank style='color:#2F92EE;'>#PRF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14669, encryptionId=f8341466954, topicName=PRF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a6716763517, createdName=12498b3em13(暂无昵称), createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601260, encodeId=31f81601260ac, content=<a href='/topic/show?id=eb1b5282260' target=_blank style='color:#2F92EE;'>#恒牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52822, encryptionId=eb1b5282260, topicName=恒牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27f418863982, createdName=zhaozuguo, createdTime=Sun Nov 04 10:07:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031964, encodeId=534410319640b, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046662, encodeId=b9ed1046662e8, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Nov 02 22:07:00 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
    2018-11-02 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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