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Thorax：肺清除指数对肺囊性纤维化患儿的实用性！

2018-02-20 MedSci MedSci原创

肺清除指数肺囊性纤维化患儿
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学龄前儿童囊性纤维化（CF）的肺部症状使用抗生素治疗的效果千差万别。肺清除指数（LCI）对早期CF肺疾病较敏感，但目前尚未评估其用于监测幼儿肺部疾病加重的效用。近期，一项发表在杂志Thorax上的研究旨在（1）了解LCI在下呼吸道症状期间如何相对于最近的临床稳定测量值发生变化，（2）确定LCI是否能够识别抗生素治疗反应，以及（3）比较LCI变化与肺量测定指标的变化。此项研究受试人群为学龄前CF儿童

学龄前儿童囊性纤维化（CF）的肺部症状使用抗生素治疗的效果千差万别。肺清除指数（LCI）对早期CF肺疾病较敏感，但目前尚未评估其用于监测幼儿肺部疾病加重的效用。近期，一项发表在杂志Thorax上的研究旨在（1）了解LCI在下呼吸道症状期间如何相对于最近的临床稳定测量值发生变化，（2）确定LCI是否能够识别抗生素治疗反应，以及（3）比较LCI变化与肺量测定指标的变化。此项研究受试人群为学龄前CF儿童患者，在12个月的时间内于门诊就诊时测量受试者的LCI和肺功能。随访患者的症状并将其分为治疗或未治疗。使用倾向评分匹配方法评估治疗响应。最终，共78名参与者确诊了104次症状性就诊。在治疗（平均相对变化+ 23.8％（95％CI 16.2至31.4））和未经治疗（平均相对变化+ 11.2％（95％CI 2.4至19.9））的症状性就诊期间，LCI从基线值增加。当使用LCI作为结果量度时，观察到显着的抗生素治疗效果（平均治疗效应-15.5％（95％CI -25.4至-5.6）），但对z评分FEV1无效。此项研究结果表明：LCI相对于基线的肺部症状发生显着恶化，并通过抗生素治疗得到改善。这些数据表

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1675858, encodeId=621716e58584f, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Mon May 07 14:29:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992853, encodeId=3395199285348, content=<a href='/topic/show?id=dfc082096cd' target=_blank style='color:#2F92EE;'>#肺囊性纤维化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82096, encryptionId=dfc082096cd, topicName=肺囊性纤维化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Fri Jan 18 17:29:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069700, encodeId=5f912069e0069, content=<a href='/topic/show?id=ebbc4606222' target=_blank style='color:#2F92EE;'>#实用性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46062, encryptionId=ebbc4606222, topicName=实用性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Wed Dec 19 10:29:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289737, encodeId=16ae289e3737, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Feb 21 19:51:53 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289460, encodeId=c2db2894605c, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Tue Feb 20 14:52:53 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289452, encodeId=8cd82894520d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Feb 20 13:59:38 CST 2018, time=2018-02-20, status=1, ipAttribution=)]
    2018-05-07 wolongzxh

    #囊性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1675858, encodeId=621716e58584f, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Mon May 07 14:29:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992853, encodeId=3395199285348, content=<a href='/topic/show?id=dfc082096cd' target=_blank style='color:#2F92EE;'>#肺囊性纤维化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82096, encryptionId=dfc082096cd, topicName=肺囊性纤维化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Fri Jan 18 17:29:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069700, encodeId=5f912069e0069, content=<a href='/topic/show?id=ebbc4606222' target=_blank style='color:#2F92EE;'>#实用性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46062, encryptionId=ebbc4606222, topicName=实用性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Wed Dec 19 10:29:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289737, encodeId=16ae289e3737, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Feb 21 19:51:53 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289460, encodeId=c2db2894605c, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Tue Feb 20 14:52:53 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289452, encodeId=8cd82894520d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Feb 20 13:59:38 CST 2018, time=2018-02-20, status=1, ipAttribution=)]
    2019-01-18 ms2694732865965676

    #肺囊性纤维化#

    0

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    2018-12-19 lidong40

    #实用性#

    0

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    2018-02-21 131****1460

    学习了受益匪浅

    0

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    2018-02-20 sunfeifeiyang

    阅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1675858, encodeId=621716e58584f, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Mon May 07 14:29:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992853, encodeId=3395199285348, content=<a href='/topic/show?id=dfc082096cd' target=_blank style='color:#2F92EE;'>#肺囊性纤维化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82096, encryptionId=dfc082096cd, topicName=肺囊性纤维化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Fri Jan 18 17:29:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069700, encodeId=5f912069e0069, content=<a href='/topic/show?id=ebbc4606222' target=_blank style='color:#2F92EE;'>#实用性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46062, encryptionId=ebbc4606222, topicName=实用性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Wed Dec 19 10:29:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289737, encodeId=16ae289e3737, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Feb 21 19:51:53 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289460, encodeId=c2db2894605c, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Tue Feb 20 14:52:53 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289452, encodeId=8cd82894520d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Feb 20 13:59:38 CST 2018, time=2018-02-20, status=1, ipAttribution=)]
    2018-02-20 医者仁心5538

    学习了

    0

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