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JACC:低心率与心衰患者预后呈显著相关

2017-10-05 MedSci MedSci原创

对于心衰伴有射血分数减少的患者,低心率与良好的预后呈相关性。然而,这种相关性在心衰伴保留型射血分数(HFpEF)患者中是否成立尚属未知。本研究纳入了8873名HFpEF(EF≥50%)住院患者,6286名患者拥有一个较稳定的心率(入院与出院心率差异≤20跳/min),其中,2369 (38%)名患者出院时的心率<70跳/min,并根据58个匹配因素对2031对患者(<70跳/min vs ≥70跳

对于心衰伴有射血分数减少的患者,低心率与良好的预后呈相关性。然而,这种相关性在心衰伴保留型射血分数(HFpEF)患者中是否成立尚属未知。

本研究纳入了8873名HFpEF(EF≥50%)住院患者,6286名患者拥有一个较稳定的心率(入院与出院心率差异≤20跳/min),其中,2369 (38%)名患者出院时的心率<70跳/min,并根据58个匹配因素对2031对患者(<70跳/min vs ≥70跳/min)进行配对分析。最终,在这4062名配对后的患者中,平均年龄为79 ± 10岁,女性占66%,10%患者是非洲裔美国人。经过6年(平均2.8年)时间的随访,出院心率<70跳/min和≥70跳/min患者的全因死亡率分别为65%和70%([HR]: 0.86; 95% [CI]: 0.80 - 0.93; p < 0.001)。低心率(<70跳/min)与心衰再住院的复合终点事件发生和全因死亡率的下降呈相关性(HR: 0.90; 95% CI: 0.84 - 0.96; p = 0.002),但与心衰再住院率(HR: 0.93; 95% CI: 0.85 - 1.01)与全因再住院率(HR: 1.01; 95% CI: 0.95 - 1.08)不呈相关性。

研究结果显示,对于心衰伴保留型射血分数的住院患者,出院时的低心率与全因死亡率的下降呈相关性,但与再住院率的下降不呈相关性。

原始出处:

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createdName=1e2332e9m29(暂无匿称), createdTime=Thu Oct 05 18:50:55 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250593, encodeId=fddb250593f1, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Oct 05 18:18:08 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250550, encodeId=476725055090, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-11-02 无怨无悔1

    心率与寿命是相关的

    0

  3. 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    2017-10-10 大爰

    学习并分享!!

    0

  4. 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createdName=1e2332e9m29(暂无匿称), createdTime=Thu Oct 05 18:50:55 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250593, encodeId=fddb250593f1, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Oct 05 18:18:08 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250550, encodeId=476725055090, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Thu Oct 05 14:53:46 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2018-06-16 hbwxf
  5. 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  6. 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  7. 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createdName=1e2332e9m29(暂无匿称), createdTime=Thu Oct 05 18:50:55 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250593, encodeId=fddb250593f1, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Oct 05 18:18:08 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250550, encodeId=476725055090, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Thu Oct 05 14:53:46 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 awesome

    心率快心脏负荷大嘛---

    0

  8. 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topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Oct 07 02:00:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250634, encodeId=5a6a25063418, content=心率快心脏负荷大嘛---, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8b81637671, createdName=awesome, createdTime=Thu Oct 05 22:24:23 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250603, encodeId=9cf92506034c, content=心率与寿命是相关的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c7052030458, createdName=1e2332e9m29(暂无匿称), createdTime=Thu Oct 05 18:50:55 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250593, encodeId=fddb250593f1, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Oct 05 18:18:08 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250550, encodeId=476725055090, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Thu Oct 05 14:53:46 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 1e2332e9m29(暂无匿称)

    心率与寿命是相关的

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1691930, encodeId=5d1f1691930d8, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Mon Aug 06 05:00:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258152, encodeId=bb5025815255, content=心率与寿命是相关的, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/26/c866646b8c2ee22bfb4ebc0b871fd1ac.jpg, createdBy=39682158353, createdName=无怨无悔1, createdTime=Thu 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createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Jun 16 01:00:00 CST 2018, time=2018-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325544, encodeId=f83a132554415, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Oct 07 02:00:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373363, encodeId=ddc813e336331, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Oct 07 02:00:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250634, encodeId=5a6a25063418, content=心率快心脏负荷大嘛---, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8b81637671, createdName=awesome, createdTime=Thu Oct 05 22:24:23 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250603, encodeId=9cf92506034c, content=心率与寿命是相关的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c7052030458, createdName=1e2332e9m29(暂无匿称), createdTime=Thu Oct 05 18:50:55 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250593, encodeId=fddb250593f1, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Oct 05 18:18:08 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250550, encodeId=476725055090, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Thu Oct 05 14:53:46 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 明天会更好!

    谢谢分享.学习了

    0

  10. 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    2017-10-05 1e0e5a1fm42(暂无匿称)

    henhao

    0

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