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JAHA:妊娠高血压疾病和子代心血管代谢健康之间的相关性分析!

2018-01-31 xing.T MedSci原创

由此可见,妊娠晚期较高的SBP和妊娠期高血压疾病与后代较高的SBP有关,但心脏代谢健康状况更好。

暴露于先兆子痫或妊娠高血压与后代较高的收缩压(SBP)有关,但与其它心脏代谢风险标志物之间的相关性尚不明确。近日,心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章

研究人员分析了1999年-2002年期间出生的参与Viva项目的1097名儿童。暴露因素包括产前记录的每个孕期的平均产妇SBP、先兆子痫或妊娠高血压。研究结局为儿童(平均8岁)SBP、全身肥胖和全身心脏代谢危险评分(包括SBP、腰围、血糖和血脂)。研究人员校正了产妇特征、后代性别和年龄后进行了线性回归分析。

在调整后的模型中,母亲先兆子痫或妊娠高血压(n=98,9.1%)与正常血压相比,子代SBP的z评分稍高(0.15单位; 95%可信区间[CI]为-0.03至0.32),但另有更好的预测心脏代谢健康标志包括代谢风险z评分(-0.23单位; 95%CI为-0.44至-0.03)及其若干组分以及较低体重指数z评分(-0.27单位; 95%CI为-0.48至-0.06)和较低的脂肪量指数(-0.91kg/m2; 95%CI为-1.35至-0.47)。同样,更高的平均孕晚期母亲SBP与较高的后代SBP的z评分(0.09单位/10mmHg; 95%CI为0.02-0.16)和较低的总体和中心肥胖相关,但与代谢风险的生物标志物无关。妊娠中期SBP的结果大致相似。妊娠早期血压与后代较高的血压相关,但与其他结局无关。

由此可见,妊娠晚期较高的SBP和妊娠期高血压疾病与后代较高的SBP有关,但心脏代谢健康状况更好。

原始出处:

Ruby Reetika Tripathi, et al. Hypertensive Disorders of Pregnancy and Offspring Cardiometabolic Health at Midchildhood: Project Viva Findings.JAHA.2018. https://doi.org/10.1161/JAHA.117.007426

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    2018-11-04 楚钟
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    2018-02-02 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1736255, encodeId=cf971e362554c, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Sun Nov 04 14:19:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1934421, encodeId=8c211934421a6, content=<a href='/topic/show?id=333851e5032' target=_blank style='color:#2F92EE;'>#心血管代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51750, encryptionId=333851e5032, topicName=心血管代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Sat Sep 15 08:19:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837445, encodeId=a042183e44599, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Jul 06 07:19:00 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267710, encodeId=68eb126e71016, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492004, encodeId=7eae149200465, content=<a href='/topic/show?id=4ff54492941' target=_blank style='color:#2F92EE;'>#妊娠高血压疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44929, encryptionId=4ff54492941, topicName=妊娠高血压疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bb88907518, createdName=zhangjiqing, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523592, encodeId=a4711523592be, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571386, encodeId=4b3915e13860b, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1736255, encodeId=cf971e362554c, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Sun Nov 04 14:19:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1934421, encodeId=8c211934421a6, content=<a href='/topic/show?id=333851e5032' target=_blank style='color:#2F92EE;'>#心血管代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51750, encryptionId=333851e5032, topicName=心血管代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Sat Sep 15 08:19:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837445, encodeId=a042183e44599, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Jul 06 07:19:00 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267710, encodeId=68eb126e71016, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492004, encodeId=7eae149200465, content=<a href='/topic/show?id=4ff54492941' target=_blank style='color:#2F92EE;'>#妊娠高血压疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44929, encryptionId=4ff54492941, topicName=妊娠高血压疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bb88907518, createdName=zhangjiqing, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523592, encodeId=a4711523592be, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571386, encodeId=4b3915e13860b, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1736255, encodeId=cf971e362554c, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Sun Nov 04 14:19:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1934421, encodeId=8c211934421a6, content=<a href='/topic/show?id=333851e5032' target=_blank style='color:#2F92EE;'>#心血管代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51750, encryptionId=333851e5032, topicName=心血管代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Sat Sep 15 08:19:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837445, encodeId=a042183e44599, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Jul 06 07:19:00 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267710, encodeId=68eb126e71016, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492004, encodeId=7eae149200465, content=<a href='/topic/show?id=4ff54492941' target=_blank style='color:#2F92EE;'>#妊娠高血压疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44929, encryptionId=4ff54492941, topicName=妊娠高血压疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bb88907518, createdName=zhangjiqing, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523592, encodeId=a4711523592be, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571386, encodeId=4b3915e13860b, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Fri Feb 02 00:19:00 CST 2018, time=2018-02-02, status=1, ipAttribution=)]
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