Baidu
map

Cochrane Database Syst Rev:强化降糖可预防1型糖尿病患者神经病变进展

2012-08-01 不详 网络

10%的糖尿病患者在确诊时已伴有神经病变,10年后该比例升至40%~50%。强化血糖控制可能是预防这种致残疾病的最佳干预方式,但迄今仍无相关系统综述。 为此,作者在Cochrane神经肌肉疾病组专业注册数据库、CENTRAL、MEDLINE和EMBASE上查找了对糖尿病患者强化降糖的随机对照试验。主要监测指标是根据临床分级定义的临床神经病变的每年进展,次要指标包括运动神经传导速率和定量振动测

10%的糖尿病患者在确诊时已伴有神经病变,10年后该比例升至40%~50%。强化血糖控制可能是预防这种致残疾病的最佳干预方式,但迄今仍无相关系统综述。

为此,作者在Cochrane神经肌肉疾病组专业注册数据库、CENTRAL、MEDLINE和EMBASE上查找了对糖尿病患者强化降糖的随机对照试验。主要监测指标是根据临床分级定义的临床神经病变的每年进展,次要指标包括运动神经传导速率和定量振动测试。

两名作者分别对检索到的题目和摘要进行评估,根据标准的数据提取表采集数据,由第三名作者协调冲突。采用年度风险差(RDs)分析临床神经病变,并采用年度均数差(MDs)评价传导速率和定量速率。


结果共纳入17项随机研究。其中7项研究是关于1型糖尿病患者,8项是关于2型糖尿病患者,还有2项研究同时包括两类糖尿病。分析结果显示,在1,228例1型糖尿病患者中,接受强化血糖控制者的临床神经病变进展风险显著降低,年度风险差为-1.84%(95%CI,-1.11~-2.56)。在6,669例2型糖尿病患者中,强化降糖者的临床神经病变进展的年度风险差异为-0.58%(95%CI,0.01~-1.17)。多数次要指标显示强化治疗有明显益处。但是,接受强化降糖的两类糖尿病患者的严重不良事件(包括低血糖事件)明显增加。


作者指出,强化血糖控制能有效预防1型糖尿病患者的临床神经病变进展并减少神经传导和振动阈值异常。对2型糖尿病患者而言,强化血糖控制有降低临床神经病变风险的趋势但未达到统计学显著性(P=0.06)。不过,强化降糖显著增加了严重低血糖事件的风险,在评估其风险/获益比时必须考虑到这一点。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1784108, encodeId=ed0a1e8410823, content=<a href='/topic/show?id=ea195e213e' target=_blank style='color:#2F92EE;'>#Database#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5721, encryptionId=ea195e213e, topicName=Database)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Thu Sep 13 22:01:00 CST 2012, time=2012-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968165, encodeId=63e3196816545, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Tue Jun 11 21:01:00 CST 2013, time=2013-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003831, encodeId=337a2003831ab, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Sat Jul 13 04:01:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465980, encodeId=fbd2146598092, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473660, encodeId=5da214e366066, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491212, encodeId=943914912122b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500313, encodeId=7f58150031325, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1784108, encodeId=ed0a1e8410823, content=<a href='/topic/show?id=ea195e213e' target=_blank style='color:#2F92EE;'>#Database#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5721, encryptionId=ea195e213e, topicName=Database)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Thu Sep 13 22:01:00 CST 2012, time=2012-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968165, encodeId=63e3196816545, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Tue Jun 11 21:01:00 CST 2013, time=2013-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003831, encodeId=337a2003831ab, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Sat Jul 13 04:01:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465980, encodeId=fbd2146598092, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473660, encodeId=5da214e366066, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491212, encodeId=943914912122b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500313, encodeId=7f58150031325, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1784108, encodeId=ed0a1e8410823, content=<a href='/topic/show?id=ea195e213e' target=_blank style='color:#2F92EE;'>#Database#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5721, encryptionId=ea195e213e, topicName=Database)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Thu Sep 13 22:01:00 CST 2012, time=2012-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968165, encodeId=63e3196816545, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Tue Jun 11 21:01:00 CST 2013, time=2013-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003831, encodeId=337a2003831ab, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Sat Jul 13 04:01:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465980, encodeId=fbd2146598092, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473660, encodeId=5da214e366066, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491212, encodeId=943914912122b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500313, encodeId=7f58150031325, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1784108, encodeId=ed0a1e8410823, content=<a href='/topic/show?id=ea195e213e' target=_blank style='color:#2F92EE;'>#Database#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5721, encryptionId=ea195e213e, topicName=Database)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Thu Sep 13 22:01:00 CST 2012, time=2012-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968165, encodeId=63e3196816545, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Tue Jun 11 21:01:00 CST 2013, time=2013-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003831, encodeId=337a2003831ab, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Sat Jul 13 04:01:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465980, encodeId=fbd2146598092, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473660, encodeId=5da214e366066, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491212, encodeId=943914912122b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500313, encodeId=7f58150031325, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
    2012-08-03 bbjsj_1981
  5. [GetPortalCommentsPageByObjectIdResponse(id=1784108, encodeId=ed0a1e8410823, content=<a href='/topic/show?id=ea195e213e' target=_blank style='color:#2F92EE;'>#Database#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5721, encryptionId=ea195e213e, topicName=Database)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Thu Sep 13 22:01:00 CST 2012, time=2012-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968165, encodeId=63e3196816545, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Tue Jun 11 21:01:00 CST 2013, time=2013-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003831, encodeId=337a2003831ab, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Sat Jul 13 04:01:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465980, encodeId=fbd2146598092, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473660, encodeId=5da214e366066, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491212, encodeId=943914912122b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500313, encodeId=7f58150031325, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1784108, encodeId=ed0a1e8410823, content=<a href='/topic/show?id=ea195e213e' target=_blank style='color:#2F92EE;'>#Database#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5721, encryptionId=ea195e213e, topicName=Database)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Thu Sep 13 22:01:00 CST 2012, time=2012-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968165, encodeId=63e3196816545, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Tue Jun 11 21:01:00 CST 2013, time=2013-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003831, encodeId=337a2003831ab, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Sat Jul 13 04:01:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465980, encodeId=fbd2146598092, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473660, encodeId=5da214e366066, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491212, encodeId=943914912122b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500313, encodeId=7f58150031325, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
    2012-08-03 axin012
  7. [GetPortalCommentsPageByObjectIdResponse(id=1784108, encodeId=ed0a1e8410823, content=<a href='/topic/show?id=ea195e213e' target=_blank style='color:#2F92EE;'>#Database#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5721, encryptionId=ea195e213e, topicName=Database)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Thu Sep 13 22:01:00 CST 2012, time=2012-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968165, encodeId=63e3196816545, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Tue Jun 11 21:01:00 CST 2013, time=2013-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003831, encodeId=337a2003831ab, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Sat Jul 13 04:01:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465980, encodeId=fbd2146598092, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473660, encodeId=5da214e366066, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491212, encodeId=943914912122b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500313, encodeId=7f58150031325, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
Baidu
map
Baidu
map
Baidu
map