Lancet：使用肾素-血管紧张素-醛固酮系统抑制剂不增加新冠肺炎感染风险

2020-05-16 MedSci MedSci原创

使用肾素-血管紧张素-醛固酮系统抑制剂不会增加新冠肺炎感染风险

有患者担心使用肾素-血管紧张素-醛固酮系统(RAAS)抑制剂可能会导致使用者感染COVID-19风险增加，但这一观点缺乏流行病学证据。近日研究人员报告了COVID-19疫情爆发以来，在西班牙马德里进行的特定病例群体研究结果。

研究人员收集了18岁或以上的新冠肺炎患者资料，患者经PCR证实诊断为COVID-19，在七家医院进行住院治疗，通过西班牙初级保健数据库（BIFAP）对病例和对照组的共病和处方信息进行收集。研究的终点为COVID-19感染入院和使用RAAS抑制剂与使用其他抗高血压药物之间的关系。

1139例病例和1139例对照参与者，其中444例（39.0%）为女性，平均年龄为69.1岁，尽管性别和年龄匹配，但与对照组相比，病例组有心血管疾病（1.98）和心血管疾病危险因素（1.46）的比例更高。与其他抗高血压药物的使用者相比，RAAS抑制剂使用者的COVID-19感染住院治疗的比率为0.94，使用血管紧张素转换酶抑制剂（0.80）或血管紧张素受体阻滞剂（1.10）均未观察到额外的风险增加。性别、年龄和背景心血管风险调整后，使用RAAS抑制剂的糖尿病患者中COVID-19入院治疗风险降低（0.53）。

研究认为，使用肾素-血管紧张素-醛固酮系统抑制剂不会增加新冠肺炎感染风险。

原始出处：

Prof Francisco J de Abajo et al.Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital： a case-population study.Lancet. 14 May ，2020.

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2020-06-01 lancelotzzl

#肾素-血管紧张素-醛固酮系统#

73 0
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2020-12-06 1361ee8c91m

好了

114 0
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2021-03-30 zhwj

#肺炎感染#

76 0
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2020-08-10 jklm09

#抑制剂#

52 0
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2020-10-11 howi

#Lancet#

93 0
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2020-05-18 cmsvly

#醛固酮#

67 0
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2020-05-18 xiongliangxl

#血管紧张素#

51 0
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2020-05-16 公卫新人

新冠肺炎，疫情何时才能消失

64 0
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2020-05-16 goodbing

顶刊就是不一样，质量很高，内容精彩！学到很多

68 0

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Lancet：使用肾素-血管紧张素-醛固酮系统抑制剂不增加新冠肺炎感染风险

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