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CLIN CANCER RES：CTLA-4基因多态性与舒尼替尼治疗透明细胞转移性肾癌患者总生存有关

2018-06-04 MedSci MedSci原创

肾癌舒尼替尼CTLA-4
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自从TKI类药物出现后，透明细胞转移性肾细胞癌（cc-mRCC）患者生存得到改善。TKI类药物与免疫反应相互作用。CLIN CANCER RES近期发表了一篇文章，研究免疫检查点基因多态性是否与舒尼替尼治疗的cc-mRCC患者临床结局有关。

自从TKI类药物出现后，透明细胞转移性肾细胞癌（cc-mRCC）患者生存得到改善。TKI类药物与免疫反应相互作用。CLIN CANCER RES近期发表了一篇文章，研究免疫检查点基因多态性是否与舒尼替尼治疗的cc-mRCC患者临床结局有关。

作者在550例舒尼替尼治疗的cc-mRCC患者队列中研究PD-L1，PD-1和CTLA-4的27个单核苷酸多态性（SNP）与无进展生存和总生存之间可能的关系。在138例舒尼替尼治疗的cc-mRCC验证队列中验证显着相关的SNPs。最后，将发现队列和验证队列的数据进行荟萃meta分析。研究结果发现，CTLA4-rs231775和CD274 rs7866740在修正了年龄，性别等因素后在发现队列中与总生存显着相关。在验证队列中，两个SNPs和总生存之间的关系未达到统计学显着意义。meta分析后，CTLA-4 rs231775与总生存显着相关。GG亚型的患者总生存优于AG亚型或AA亚型患者。未发现与无进展生存之间的显着相关性。

文章最后认为，CTLA-4基因的rs231775与舒尼替尼治疗的cc-mRCC患者总生存改善有关，可以用作预后标志。

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    2018-06-06 1249842em09(暂无昵称)

    #转移性#

    0

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    2018-06-06 zz72

    #细胞转移#

    0

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    2018-06-06 hywen7328

    #CTLA-4#

    0

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    2018-06-06 xzw120

    #多态性#

    0

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    2018-06-06 大爰

    学习了谢谢分享!!

    0

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