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PLoS One:角膜内皮细胞-基底膜组织的蛋白质组学分析

2018-03-14 cuiguizhong MedSci原创

美国爱荷华大学卡弗医学院眼科和视觉科学的Skeie JM近日在PLoS One发表一项重要工作,他们研究了患各种II型糖尿病患者和健康对照组中角膜内皮细胞层及其基底膜(Descemet膜)的蛋白质组,并通过比较,鉴定了一系列随糖尿病疾病严重程度不同而差异表达的蛋白质,而这些蛋白可能会影响角膜内皮细胞的健康。

美国爱荷华大学卡弗医学院眼科和视觉科学的Skeie JM近日在PLoS One发表一项重要工作,他们研究了患各种II糖尿病患者和健康对照组中角膜内皮细胞层及其基底膜(Descemet膜)的蛋白质组,并通过比较,鉴定了一系列随糖尿病疾病严重程度不同而差异表达的蛋白质,而这些蛋白可能会影响角膜内皮细胞的健康。

从接受角膜移植的供体患者获得角膜,剥离内皮 基底膜组织。从每个样品中分离蛋白质组分,并进行多维液相色谱和串联质谱。将肽谱与人类蛋白质组进行匹配,判断基因本体,并将其分为每种疾病状态下独特的蛋白质信号传导途径。


他们在每种内皮 - Descemet膜复合组织样品中鉴定出约12,472种独特蛋白质。其中有2,409个差异表达的蛋白质异构体,这些蛋白与代谢过程、氧化应激和炎症有关,上述因素也是已知的II糖尿病危险因素。基因本体研究分析表明,在糖尿病不同的疾病过程中,发现许多与代谢过程、结合和催化有关的蛋白质。与糖尿病发展最相关的信号途径包括线粒体功能障碍、细胞-细胞连接结构和蛋白质合成调节。

该蛋白质组学数据发现了新型角膜内皮细胞和Descemet膜蛋白在糖尿病疾病各个阶段的表达不同。这些发现,为角膜内皮细胞及其基底膜相关的糖尿病发展机制提供了新的研究思路,发现了潜在的用于靶向治疗的新途径。

 

原文出处:

Skeie, J.M., et al., Proteomic analysis of corneal endothelial cell-descemet membrane tissues reveals influence of insulin dependence and disease severity in type 2 diabetes mellitus. PLoS One, 2018. 13(3): p. e0192287.

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    2018-03-16 snowpeakxu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1790121, encodeId=df231e90121ef, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Aug 31 18:29:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765710, encodeId=27381e6571069, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Jun 19 15:29:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754832, encodeId=53201e54832b0, content=<a href='/topic/show?id=0a1688e33b3' target=_blank style='color:#2F92EE;'>#蛋白质组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88733, encryptionId=0a1688e33b3, topicName=蛋白质组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cf6736789983, createdName=jjjiang0211, createdTime=Sun Apr 22 16:29:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297032, encodeId=f1b9129e0329a, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Mar 16 11:29:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349123, encodeId=0b081349123ad, content=<a href='/topic/show?id=4337909284a' target=_blank style='color:#2F92EE;'>#角膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90928, encryptionId=4337909284a, topicName=角膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Fri Mar 16 11:29:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296254, encodeId=4c2629625400, content=学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Mar 14 22:31:55 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-14 1ddf0692m34(暂无匿称)

    学习了.

    0

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