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Nature Commun:多模态磁共振神经影像学靶点浮出水面

2018-08-08 柯讯 中国科学报

近日,中国科学院自动化研究所研究员隋婧团队在《自然—通讯》上发表了其在神经影像学靶点研究中取得的最新进展。


近日,中国科学院自动化研究所研究员隋婧团队在《自然—通讯》上发表了其在神经影像学靶点研究中取得的最新进展。

认知功能损伤被认为是精神分裂症等多种脑疾病中广泛存在的核心功能损伤。精神疾病临床表现复杂,主观性诊断、经验化治疗等问题突出,迫切需要研究能够评估和衡量患者多种认知能力损伤的客观影像学靶点,并以此推动基于影像学的辅助诊断和个体化精准治疗。

该研究团队面向脑科学与信息科学交叉前沿,开展脑影像的模式识别研究,分析比较了3组独立样本和7种认知子域评分,发现了一组通用的多模态磁共振影像学靶点,可实现精神分裂症多种认知能力的个体化预测,并成功在多中心验证推广,深入揭示了精神分裂症认知损伤所影响的多模态交互环路,为建立基于客观标记物的个体化治疗系统奠定基础。

该研究基于多维度指标整合挖掘,发现了一组可靠的、能够衡量多种认知能力的影像学标记,有望优化精神分裂症的早期干预和治疗评估,减少不良反应,进而推动精神疾病的精准诊疗研究,具有重大的社会经济价值。

原始出处

Jing Sui, et al.Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion.Nature Communicationsvolume 9, Article number: 3028 (2018) 

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    2019-01-05 liye789132251
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    2019-01-25 liuli5079
  6. [GetPortalCommentsPageByObjectIdResponse(id=2019751, encodeId=35682019e51e6, content=<a href='/topic/show?id=5ecde428074' target=_blank style='color:#2F92EE;'>#神经影像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74280, encryptionId=5ecde428074, topicName=神经影像)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ab72500038, createdName=124985dbm06(暂无昵称), createdTime=Thu May 23 20:12:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992217, encodeId=61bf199221e56, content=<a href='/topic/show?id=6790433126e' target=_blank style='color:#2F92EE;'>#多模态磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43312, encryptionId=6790433126e, topicName=多模态磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Thu Jan 17 23:12:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022385, encodeId=a0462022385fe, content=<a href='/topic/show?id=907243308f5' target=_blank style='color:#2F92EE;'>#多模态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43308, encryptionId=907243308f5, topicName=多模态)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Fri Feb 22 23:12:00 CST 2019, time=2019-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883232, encodeId=cc0b18832327d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 05 22:12:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087397, encodeId=f4dc208e397b9, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jan 25 18:12:00 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341627, encodeId=38c1134162e45, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Aug 10 13:12:00 CST 2018, time=2018-08-10, status=1, ipAttribution=)]
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