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Clin Gastroenterology H: 布地奈德口服液可以改善嗜酸性食管炎患者的结局

2021-04-23 MedSci原创 MedSci原创

嗜酸性食管炎(EoE)是一种慢性的,免疫介导的疾病,组织学表现为以嗜酸性细胞浸润和相关的内镜下特征持续存在为特征。

      嗜酸性食管炎(EoE)是一种慢性的,免疫介导的疾病,组织学表现为以嗜酸性细胞浸润和相关的内镜下特征持续存在为特征,患者具有明显的临床表现(如上腹痛、烧心、吞咽困难和食物噎塞等),甚至伴发严重的并发症。目前尚无FDA批准的药物可以有效治疗此疾病。本项研究对激素——布地奈德口服液对于嗜酸性食管的治疗效果进行了探究。

 

      在这项双盲,安慰剂对照试验中,年龄在11至55岁之间的EoE患者和存在吞咽困难的患者被随机分配接受布地奈德口服混悬液(BOS)2.0 mg/2次/天或安慰剂治疗,试验维持12周。主要观察终点是在12周内患者是否存在组织学应答(≤6个嗜酸性粒细胞/高倍视野)或吞咽困难症状得到缓解(吞咽困难症状问卷[DSQ]评分降低≥30%)。从基线到第12周,DSQ得分和EoE内窥镜参考得分(EREFS)的变化也是研究人员关注的重点之一。

 

      最后总共有318例患者参与了本项研究(BOS组 213名;安慰剂组105名),经过BOS治疗的患者比接受安慰剂治疗的患者获得更好的组织学应答(53.1%VS 1.0%;P <.001)或症状应答(52.6% vs 39.1%;P = .024)。与安慰剂治疗的患者相比,BOS治疗的患者在12周内的DSQ评分和EREFS改善也更大:(DSQ-13.0(1.2) VS -9.1(1.5);EREFS,-4.0(0.3) VS -2.2(0.4)P<.001)。

 图:布地奈德治疗嗜酸性食管炎后炎症指标的变化

      本项研究证实在EoE患者中,接受布地奈德口服液治疗后12周内可以很好地改善患者的组织学,临床症状和内镜下表现。

 

 

原始出处:

Ikuo Hirano. et al. Budesonide Oral Suspension Improves Outcomes in Patients With Eosinophilic Esophagitis: Results from a Phase 3 Trial. Clinical Gastroenterology and Hepatology.2021.

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    2021-11-07 songbq
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    2021-06-11 122febb4m88暂无昵称

    受益匪浅

    0

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GetPortalCommentsPageByObjectIdResponse(id=1437628, encodeId=56ae143e62888, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Apr 25 00:55:22 CST 2021, time=2021-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462549, encodeId=77e5146254946, content=<a href='/topic/show?id=d627101081d8' target=_blank style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Sun Apr 25 00:55:22 CST 2021, time=2021-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505235, encodeId=6b931505235db, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Apr 25 00:55:22 CST 2021, time=2021-04-25, status=1, ipAttribution=)]
    2022-04-01 许安
  8. 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encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Sun Apr 25 00:55:22 CST 2021, time=2021-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505235, encodeId=6b931505235db, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Apr 25 00:55:22 CST 2021, time=2021-04-25, status=1, ipAttribution=)]
    2021-04-25 zhouqu_8
  9. 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  10. 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