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Ann Rheum Dis:引入生物性DMARDs后类风湿性关节炎髋关节和膝关节置换的发生率

2017-12-20 xiangting MedSci原创

在1996年与GPC相比,RA患者中THR和TKR的发生率分别高3倍和14倍。

这项研究旨在探讨引入生物性疾病改善抗风湿药物(bDMARDs)和相关类风湿性关节炎(RA管理指南对丹麦全髋关节(THR)和膝关节置换(TKR)发生率的影响。

这是一项以全国性登记为基础的队列和间断时序分析。在1996年至2011年丹麦全国患者登记中查找偶发性RA患者。RA患者根据年龄、性别和所在市与10个普通人(GPC)相匹配。计算6个月中RA患者和GPC1000人年THRTKR的标准化5年发病率。采用分段线性回归,其中间隔1年的滞后期(2002年),对bDMARD前(1996 - 2001年)的水平和趋势与bDMARD时期(2003 - 2016年)进行比较。

共确定了30 404RA患者和297 916GPC1996年,RA患者的THRTKR发生率分别为8.725.87GPC的发生率分别为2.890.42。从1996年到2016年,RA患者THR发病率有所下降,而GPC则有所增加。在RA患者中,TKR的发病率从1996年到2001年有所上升,但从2003年开始下降,并贯穿整个bDMARD时期。1996年至2016年间,GPCTKR的发病率有所升高。

这项研究发现,在1996年与GPC相比,RA患者中THRTKR的发生率分别高3倍和14倍。在RA患者中,引入bDMARDsTKR发病率降低相关,而在bDMARD引入前THR的发生率已经开始下降了。

原始出处:

René Lindholm Cordtz, et al. Incidence of hip and knee replacement in patients with rheumatoid arthritis following the introduction of biological DMARDs: an interrupted time-series analysis using nationwide Danish healthcare registers. Ann Rheum Dis. 15 December 2017.

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    2018-09-14 drwjr
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topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sun Dec 31 07:33:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273453, encodeId=486e2e3453ae, content=学习谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Fri Dec 29 08:15:09 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272219, encodeId=fc162e221958, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Dec 24 22:06:23 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265605, encodeId=a93c12656058a, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333965, encodeId=f090133396590, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395313, encodeId=dbfb139531352, content=<a href='/topic/show?id=019a60434f' target=_blank style='color:#2F92EE;'>#DMARDs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6043, encryptionId=019a60434f, topicName=DMARDs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3ad2500191, createdName=12498dd9m11暂无昵称, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483458, encodeId=344914834588f, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
    2017-12-31 yxch48
  5. 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style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395313, encodeId=dbfb139531352, content=<a href='/topic/show?id=019a60434f' target=_blank style='color:#2F92EE;'>#DMARDs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6043, encryptionId=019a60434f, topicName=DMARDs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3ad2500191, createdName=12498dd9m11暂无昵称, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483458, encodeId=344914834588f, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
    2017-12-29 lou.minghong

    学习谢谢分享!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2012524, encodeId=2c702012524df, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Feb 17 03:33:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040236, encodeId=0e7420402361d, content=<a href='/topic/show?id=cb0b1520365' target=_blank style='color:#2F92EE;'>#RDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15203, encryptionId=cb0b1520365, topicName=RDS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, 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topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sun Dec 31 07:33:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273453, encodeId=486e2e3453ae, content=学习谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Fri Dec 29 08:15:09 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272219, encodeId=fc162e221958, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395313, encodeId=dbfb139531352, content=<a href='/topic/show?id=019a60434f' target=_blank style='color:#2F92EE;'>#DMARDs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6043, encryptionId=019a60434f, topicName=DMARDs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3ad2500191, createdName=12498dd9m11暂无昵称, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483458, encodeId=344914834588f, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Dec 22 07:33:00 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
    2017-12-24 wxl882001

    学习一下

    0

  7. 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    2017-12-22 lmm397
  8. 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  9. 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本研究的目的是评估类风湿关节炎(RA)患者的口腔健康相关生活质量(OHRQoL),取决于其与健康对照(HCs)的口腔健康状况。

ARTHRIT CARE RES:母亲类风湿性关节炎长期影响后代健康

患有类风湿性关节炎(RA)的母亲可能具有影响后代疾病情况的长期风险。近日,来自欧登塞大学医院的研究人员测试了母亲患有RA和后代中15个选定的慢性病组之间是否存在可能的关联。

Ann Rheum Dis:患者特征影响RA生物性药物的选择,并使非TNFi生物制剂显得比TNFi生物制剂更有害

年龄较大和病情较重的RA患者更容易使用非TNFi bDMARDs,尤其是作为首个bDMARD。

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