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JAHA:内脏脂肪组织和骨骼肌密度与卒中、心梗和全因死亡的关系

2021-04-18 MedSci原创 MedSci原创

VAT是肥胖相关的重要预测因子,可预测70岁以上男性的心血管风险,减少VAT可能会降低心血管疾病的风险。

衰老导致内脏脂肪组织(VAT)增加和骨骼肌密度降低。这些因素在多大程度上与卒中、心肌梗塞(MI)的风险以及老年人的全因死亡率有关,尚未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究总有3294名(49.6%为女性)70岁以上的老年人在2012年至2018年期间进行了健康检查。

研究人员使用双能X线骨密度仪和外周定量计算机断层扫描技术测量了VAT和肌肉密度。研究人员通过国家登记中心收集了卒中、心梗和全因死亡病例,并使用Cox回归来计算VAT没增加1个SD和肌肉密度每降低1个SD的危险比(HR)和95%CI。

在平均3.6年的随访中,共出现108例卒中或心肌梗塞病例,其中97例死亡病例。较高的VAT(调整后的HR [aHR]为1.56;95%CI为1.09–2.22),而不是较低的肌肉密度(aHR为1.14;95%CI为0.97-1.34)与卒中或MI风险增加相关。VAT(aHR为0.95;95%CI为0.65-1.41)和肌肉密度(aHR为1.11;95%CI为0.92-1.34)均与全因死亡率无关。VAT与卒中或心肌梗死的相关性仅在男性(aHR为1.86; 95%CI为1.19–2.91)中显著,而在女性中(aHR为0.60; 95%CI为0.25–1.42)则无统计学意义(交互作用P=0.038)。

这项观察性研究的结果表明,VAT是肥胖相关的重要预测因子,可预测70岁以上男性的心血管风险,减少VAT可能会降低心血管疾病的风险

原始出处:

Marcel Ballin.et al.Associations of Visceral Adipose Tissue and Skeletal Muscle Density With Incident Stroke, Myocardial Infarction, and All‐Cause Mortality in Community‐Dwelling 70‐Year‐Old Individuals: A Prospective Cohort Study.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.020065

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    2022-05-29 ms6000001791212108

    学习了

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    2021-04-20 zhaohui6731
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    2021-04-19 ZJY

    I've been taught.+2

    3

    展开3条回复
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    2021-04-18 lmelody

    学习了

    0

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    2021-04-18 ms2000001051330459

    学习了,涨知识了!

    0

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    2021-04-18 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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