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Diabetes Care:你以为维持减肥就对2型糖尿病患者真正有益吗?

2016-07-23 fsy 译 MedSci原创

短期减肥可以改善心血管疾病(CVD)的危险因素。该研究试图确定维持减肥,或者反过来,恢复体重的长期影响。研究人员使用了来自糖尿病健康行动(Look AHEAD)的研究数据,Look AHEAD研究是一项随机试验,该试验在2型糖尿病患者中比较了强化生活方式干预(ILI)和条件控制的效果。ILI参与者根据体重变化模式分组:1)体重未下降(在第1和第4年时±3%);2)适度减肥(在第1和第4年时3-8%

短期减肥可以改善心血管疾病(CVD)的危险因素。该研究试图确定维持减肥,或者反过来,恢复体重的长期影响。

研究人员使用了来自糖尿病健康行动(Look AHEAD)的研究数据,Look AHEAD研究是一项随机试验,该试验在2型糖尿病患者中比较了强化生活方式干预(ILI)和条件控制的效果。ILI参与者根据体重变化模式分组:1)体重未下降(在第1和第4年时±3%);2)适度减肥(在第1和第4年时3-8%);3)较大程度的减肥(在第1和第4年时8-20%);4)中度减肥/完全恢复(在第1年时3-8%,在第4年时1/±3%);5)较大程度的减肥/完全恢复(在第1年时8-20%,在第4年时±3%);和6)较大程度的减肥/部分恢复(在第1年时8-20%,在第4年时3-8%),研究人员也对心血管疾病的风险因素变化进行了比较。

调整了基线差异和药物使用后,研究人员发现,在第1年和第4年时,体重下降程度越大的参与者,其HbA1c、收缩压、HDL胆固醇和甘油三酯水平就会有更大的改善(所有P≤0.02)。尽管维持了减肥的状况,HbA1c水平在第1年和第4年之间还是恶化了,只有在那些较大程度减肥的参与者的HbA1c水平维持在基线水平以下。减肥和体重恢复相对于没有减肥的人来说,研究人员并没有发现相互之间有负面联系。此外,那些在开始时减肥但在第4年体重完全恢复的人相对于在开始时没有减肥的人来说,HbA1c水平有了更大的改善。

尽管体重有恢复的可能性,但还是要鼓励那些2型糖尿病患者在患病初期去进行较大程度的减肥。

原始出处:

The Action for Health in Diabetes (Look AHEAD) Study Group,Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors,Diabetes Care,2016.7.23

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    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-13 舒心和人

    肥胖的患者体内脂肪含量多,内脏脂肪也不会少,会造成胰岛素抵抗,所以减肥利于健康

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1637411, encodeId=3434163e41199, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jul 27 05:57:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901421, encodeId=c58a19014217c, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Mar 24 22:57:00 CST 2017, time=2017-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759722, encodeId=03ed1e597227d, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Sep 09 15:57:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131786, encodeId=c2d8131e8685, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:36:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125609, encodeId=058212560939, content=肥胖的患者体内脂肪含量多,内脏脂肪也不会少,会造成胰岛素抵抗,所以减肥利于健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 18:28:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383237, encodeId=2f11138323ec8, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Mon Jul 25 13:57:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474024, encodeId=6d8114e40244c, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Jul 25 13:57:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
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